Results 11 to 20 of about 8,953 (240)

Total Synthesis of 6-Deoxydihydrokalafungin, a Key Biosynthetic Precursor of Actinorhodin, and Its Epimer

Molecules, 2021
In this article, we report the total synthesis of 6-deoxydihydrokalafungin (DDHK), a key biosynthetic intermediate of a dimeric benzoisochromanequinone antibiotic, actinorhodin (ACT), and its epimer, epi-DDHK.
Takuya Kumamoto, Mika Kainuma, Azusa Takahashi, Yoshika Matsuo, Kazuaki Katakawa, Takaaki Taguchi, Koji Ichinose   +6 more
doaj   +1 more source

Syntheses of Natural (–)-Osmundalactone and Its Epimer [PDF]

Agricultural and Biological Chemistry, 1986
(–)-Osmundalactone, an aglycone of osmundalin, and its 5-epimer were synthesized from 3-triethylsiloxy-1-propyne and from (S)-1-methyl-2-oxoethyl benzoate, which was derived from 2,3-O-cyclohexylidene-d-glyceraldehyde.
MURAYAMA, Tetsuya, SUGIYAMA, Takeyoshi, YAMASHITA, Kyohei   +2 more
openaire   +2 more sources

The genetic determinants of circulating C3-epimers of 25-hydroxyvitamin D

Journal of Clinical & Translational Endocrinology, 2018
Background: The complexity of vitamin D metabolites especially the contribution of C3-epimers of 25-hydroxyvitamin D (C3-epimers) in human sera remains unclear.
Sirikunya Torugsa, Hataikarn Nimitphong, Daruneewan Warodomwichit, La-or Chailurkit, Kriangsuk Srijaruskul, Suwannee Chanprasertyothin, Boonsong Ongphiphadhanakul   +6 more
doaj   +1 more source

Effects of Continuously Feeding Diets Containing Cereal Ergot Alkaloids on Nutrient Digestibility, Alkaloid Recovery in Feces, and Performance Traits of Ram Lambs

Toxins, 2017
Allowable limits for cereal ergot alkaloids in livestock feeds are being re-examined, and the objective of this study was to compare nutrient digestibility, growth performance and carcass characteristics of ram lambs fed a range of alkaloid ...
Stephanie Coufal-Majewski, Kim Stanford, Tim McAllister, Yuxi Wang, Barry Blakley, John McKinnon, Mary Lou Swift, Alexandre V. Chaves   +7 more
doaj   +1 more source

Epimers with distinct mechanical behaviours

CrystEngComm, 2021
Two epimeric series of esters exhibit distinct mechanical behaviour: brittle crystals for one series and ductile crystals for the other series.
Udaya B. Rao Khandavilli, Aoife M. Buckley, Anita R. Maguire, Mangalampalli S. R. N. Kiran, Upadrasta Ramamurty, Simon E. Lawrence   +5 more
openaire   +2 more sources

Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer

Medicines, 2019
Breast cancer is still one of the most prevalent cancers and a leading cause of cancer death worldwide. The key challenge with cancer treatment is the choice of the best therapeutic agents with the least possible toxicities on the patient.
Maryam Nakhjavani, Jennifer E Hardingham, Helen M Palethorpe, Yoko Tomita, Eric Smith, Tim J Price, Amanda R Townsend   +6 more
doaj   +1 more source

Stereoselective Anti-Cancer Activities of Ginsenoside Rg3 on Triple Negative Breast Cancer Cell Models

Pharmaceuticals, 2019
Ginsenoside Rg3 (Rg3) has two epimers, 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3), and while Rg3 itself has been reported to have anti-cancer properties, few studies have been reported on the anti-cancer effects of the different ...
Maryam Nakhjavani, Helen M. Palethorpe, Yoko Tomita, Eric Smith, Timothy J. Price, Andrea J. Yool, Jinxin V. Pei, Amanda R. Townsend, Jennifer E. Hardingham   +8 more
doaj   +1 more source

Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization

Angewandte Chemie, EarlyView.
The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu, Zeliang Zhang, Benedikt Seligmann, Van Hung Bui, Tuan‐Anh Minh Nguyen, Thu‐Thuy T. Dang, Jakob Franke   +6 more
wiley   +2 more sources

Beyond Ribosomal Binding: The Increased Polarity and Aberrant Molecular Interactions of 3-epi-deoxynivalenol

Toxins, 2016
Deoxynivalenol (DON) is a secondary fungal metabolite and contaminant mycotoxin that is widely detected in wheat and corn products cultivated around the world.
Yousef I. Hassan, Honghui Zhu, Yan Zhu, Ting Zhou   +3 more
doaj   +1 more source

Toward the Synthesis of Pestalustaine A: Structural Revision and Formation of Original Strained Tricyclic Architectures

Angewandte Chemie, EarlyView.
Our synthetic endeavor toward the total synthesis of the reported unprecedented tricyclic skeleton of the sesquiterpene pestalustaine A allowed us to perform divergent cyclizations of a bicyclo[4.4.1]undec‐3‐ene into complex tricyclic architectures and to revise the structure of the natural product.
Wei Cao, Alicia Ross, Jean‐Pierre Baltaze, Régis Guillot, Menglin Xu, Rongzhen Qin, Bingcheng Yang, Isabel Wong, Katayoon Formul, Cyrille Kouklovsky, Dean J. Tantillo, Vincent Gandon, Guillaume Vincent   +12 more
wiley   +2 more sources