Results 111 to 120 of about 48,693 (213)

Selection on genome‐wide gene expression plasticity of rice in wet and dry field environments

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Gene expression can be highly plastic in response to environmental variation. However, we know little about how expression plasticity is shaped by natural selection and evolves in wild and domesticated species. We used genotypic selection analysis to characterize selection on drought‐induced plasticity of over 7,500 leaf transcripts of 118 ...
Elena Hamann, Simon C. Groen, Taryn S. Dunivant, Irina Ćalić, Colleen Cochran, Rachel Konshok, Michael D. Purugganan, Steven J. Franks   +7 more
wiley   +1 more source

Asociación y efectos de interacción en los genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R y PTGS2 sobre la hipertensión en la población antioqueña

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. La hipertensión arterial es una enfermedad multifactorial influenciada por componentes genéticos y ambientales, cuya prevalencia varía entre grupos étnicos.
Diana María Valencia, Carlos Andrés Naranjo, María Victoria Parra, María Antonieta Caro, Ana Victoria Valencia, Carlos José Jaramillo, Gabriel Bedoya   +6 more
doaj   +1 more source

Gravitropic Gene Expression Divergence Associated With Adaptation to Contrasting Environments in an Australian Wildflower

Molecular Ecology, Volume 34, Issue 15, August 2025.
ABSTRACT Plants adapt to their local environment through complex interactions between genes, gene networks and hormones. Although the impact of gene expression on trait regulation and evolution has been recognised for many decades, its role in the evolution of adaptation is still a subject of intense exploration.
Zoe Broad, James Lefevre, Melanie J. Wilkinson, Samuel Barton, Francois Barbier, Hyungtaek Jung, Diane Donovan, Daniel Ortiz‐Barrientos   +7 more
wiley   +1 more source

Poor statistical power in population-based association study of gene interaction

BMC Medical Genomics
Background Statistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype.
Jiarui Ma, Jian Li, Yuqi Chen, Zhen Yang, Yungang He   +4 more
doaj   +1 more source

KnowVolution of an Efficient Polyamidase through Molecular Dynamics Simulations of Incrementally Docked Oligomeric Substrates

ChemSusChem, Volume 18, Issue 15, July 27, 2025.
Managing synthetic polymer waste is a major challenge. While enzymatic polyamide (PA) hydrolysis holds great recycling potential, it is limited by ineffective polyamidases. The polyamidase NylCp2‐TS is evolved through random mutagenesis and incremental docking, yielding NylC‐HP with enhanced activity and stability.
Hendrik Puetz, Alexander‐Maurice Illig, Mariia Vorobii, Christoph Janknecht, Francisca Contreras, Fabian Flemig, Ulrich Schwaneberg   +6 more
wiley   +1 more source

Complexity of evolutionary equilibria in static fitness landscapes [PDF]

, 2013
A fitness landscape is a genetic space -- with two genotypes adjacent if they differ in a single locus -- and a fitness function. Evolutionary dynamics produce a flow on this landscape from lower fitness to higher; reaching equilibrium only if a local ...
Kaznatcheev, Artem
core  

The evolution of genetic architectures underlying quantitative traits

, 2013
In the classic view introduced by R. A. Fisher, a quantitative trait is encoded by many loci with small, additive effects. Recent advances in QTL mapping have begun to elucidate the genetic architectures underlying vast numbers of phenotypes across ...
Plotkin, Joshua B., Rajon, Etienne
core   +1 more source

Epistasis and immunity: the role of genetic interactions in autoimmune diseases

Immunology, 2012
SummaryAutoimmune disorders are a complex and varied group of diseases that are caused by breakdown of self‐tolerance. The aetiology of autoimmunity is multi‐factorial, with both environmental triggers and genetically determined risk factors. In recent years, it has been increasingly recognized that genetic risk factors do not act in isolation, but ...
Anna M. Rose, Lucy C K Bell
openaire   +4 more sources

3D protein structure from genetic epistasis experiments [PDF]

, 2018
SummaryHigh-throughput experimental techniques have made possible the systematic sampling of the single mutation landscape for many proteins, defined as the change in protein fitness as the result of point mutation sequence changes. In a more limited number of cases, and for small proteins only, we also have nearly full coverage of all possible double ...
Rollins, Nathan J., Brock, Kelly P., Poelwijk, Frank J., Stiffler, Michael A., Gauthier, Nicholas P., Sander, Chris, Marks, Debora S.   +6 more
openaire   +1 more source

Statistical Modeling of Epistasis and Linkage Decay using Logic Regression [PDF]

, 2007
Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for analytical precision using a previously characterized ...
John A. Henning, P Szű, Thomas Parker, W F. Mahaffee   +3 more
core   +1 more source