Results 111 to 120 of about 58,973 (229)
Loss of least-loaded class in asexual populations due to drift and epistasis [PDF]
Genetics 179, 2125 (2008), 2008 We consider the dynamics of a non-recombining haploid population of finite size which accumulates deleterious mutations irreversibly. This ratchet like process occurs at a finite speed in the absence of epistasis, but it has been suggested that synergistic epistasis can halt the ratchet. Using a diffusion theory, we find explicit analytical expressions
arxiv
Open Problems in Human Trait Genetics [PDF]
arXiv, 2021 Genetic studies of human traits have revolutionized our understanding of the variation between individuals, and opened the door for numerous breakthroughs in biology, medicine and other scientific fields. And yet, the ultimate promise of this area of research is still not fully realized. In this review, we highlight the major open problems that need to
arxiv
Studying the genetic basis of ecological interactions with intergenomic epistasis
Oikos, Volume 2025, Issue 6, June 2025.In a community, the phenotype or fitness of genotypes of a focal species can depend on the genotypes of other species. Such between‐species genetic interactions are increasingly referred to as intergenomic epistasis, analogous to the classical definition of (intragenomic) epistasis in genetics.
Loraine Hablützel, Claudia Bank
wiley +1 more source
PLoS Biology, 2017 Independently evolving populations may adapt to similar selection pressures via different genetic changes. The interactions between such changes, such as in a hybrid individual, can inform us about what course adaptation may follow and allow us to ...
Jasmine Ono +2 more
doaj +1 more source
EpiRL: A Reinforcement Learning Agent to Facilitate Epistasis Detection [PDF]
arXiv, 2018 Epistasis (gene-gene interaction) is crucial to predicting genetic disease. Our work tackles the computational challenges faced by previous works in epistasis detection by modeling it as a one-step Markov Decision Process where the state is genome data, the actions are the interacted genes, and the reward is an interaction measurement for the selected ...
arxiv
Exploiting barley landraces to reintroduce lost genetic diversity: Resistance to net form net blotch
Crop Science, Volume 65, Issue 3, May/June 2025.Abstract Centuries of barley (Hordeum vulgare) domestication and selection has resulted in reduced genetic diversity in modern cultivars, limiting breeder's options to select desirable traits. Barley landraces, heirloom varieties, and wild relatives are substantially more variable and can be exploited to reintroduce favorable genes and alleles.
Nola K. D'Souza +7 more
wiley +1 more source
Statistical Modeling of Epistasis and Linkage Decay using Logic Regression [PDF]
, 2007 Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for analytical precision using a previously characterized ...
John A. Henning +3 more
core +1 more source
Sign Epistasis and the Geometry of Interactions [PDF]
arXiv, 2018 Approaches to gene interactions based on sign epistasis have been highly influential in recent time. Sign epistasis is useful for relating local and global properties of fitness landscapes, as well as for analyzing evolutionary trajectories and constraints.
arxiv
Aging Cell, Volume 24, Issue 5, May 2025.We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan +4 more
wiley +1 more source
A Guide for Developing Demo‐Genetic Models to Simulate Genetic Rescue
Evolutionary Applications, Volume 18, Issue 5, May 2025.ABSTRACT Genetic rescue is a conservation management strategy that reduces the negative effects of genetic drift and inbreeding in small and isolated populations. However, such populations might already be vulnerable to random fluctuations in growth rates (demographic stochasticity).
Julian E. Beaman +8 more
wiley +1 more source