Results 91 to 100 of about 59,992 (241)
Genetics of Common Obesity in Children and Adolescents
Annals of the New York Academy of Sciences, EarlyView.Abstract Childhood obesity is a multifactorial public health problem worldwide. Genetic variation influences the predisposition to develop obesity at early stages of life. Childhood obesity may be classified as syndromic, monogenic, or polygenic depending on the genetic component.
Guadalupe León‐Reyes +2 more
wiley +1 more source
Historical contingency and entrenchment in protein evolution under purifying selection [PDF]
, 2014 The fitness contribution of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of evolution in populations under selection, and can shape the course of ...
McCandlish, David M. +2 more
core +2 more sources
Evaluating Methods for Modeling Epistasis Networks with Application to Head and Neck Cancer
Cancer Informatics, 2015 Epistasis helps to explain how multiple single-nucleotide polymorphisms (SNPs) interact to cause disease. A variety of tools have been developed to detect epistasis.
Rajesh Talluri, Sanjay Shete
doaj +1 more source
Privacy-preserving decision tree for epistasis detection
Cybersecurity, 2019 The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
doaj +1 more source
Plant Breeding, EarlyView.ABSTRACT Cucumis melo, a sweet‐tasting fruit from the Cucurbitaceae family, is popular in global markets. While some varieties of C. melo are used for pickling or salads, melons such as cantaloupes and honeydews are consumed as a dessert. Desirable appearance, shelf life and palatability are crucial in determining a variety's success.
Cheyenne G. Cotie +3 more
wiley +1 more source
Robustness and epistasis in mutation-selection models
, 2009 We investigate the fitness advantage associated with the robustness of a phenotype against deleterious mutations using deterministic mutation-selection models of quasispecies type equipped with a mesa shaped fitness landscape.
Andrea Wolff +11 more
core +2 more sources
Mean and variance heterogeneity loci impact kernel compositional traits in maize
The Plant Genome, Volume 18, Issue 4, December 2025.Abstract Maize (Zea mays) kernel composition is critical for food, feed, and industrial applications. Improving traits such as starch, protein, oil, fiber, and ash requires understanding their genetic basis. We conducted genome‐wide association studies (GWAS) and variance genome‐wide association studies (vGWAS) analyses using 954 inbred lines from the ...
Yasser M. A. Ismail +5 more
wiley +1 more source
Exact Results for Amplitude Spectra of Fitness Landscapes
, 2013 Starting from fitness correlation functions, we calculate exact expressions for the amplitude spectra of fitness landscapes as defined by P.F. Stadler [J. Math. Chem.
Krug, Joachim +2 more
core +1 more source
The Plant Genome, Volume 18, Issue 4, December 2025.Abstract We conducted simulations of common bean (Phaseolus vulgaris L.) breeding programs to better understand the interplay between different choices a breeder must make when launching a genomic selection (GS) pipeline. We complement preceding studies on optimizing model parameters and training set makeup by exploring the practical implementation of ...
Isabella Chiaravallotti +1 more
wiley +1 more source
BioData MiningPurpose Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all
Sandra Batista +8 more
doaj +1 more source