Results 91 to 100 of about 38,773 (257)
PLoS Computational BiologyEpistasis among driver mutations is pervasive and explains relevant features of cancer, such as differential therapy response and convergence towards well-characterized molecular subtypes.
Carla Alejandre +2 more
doaj +1 more source
Molecular Ecology, EarlyView.ABSTRACT Predicting the long‐term impact of releases and introgression from non‐native strains into wild populations remains an important conservation issue, particularly in fishes where stocking and aquaculture escapes have led to widespread genetic admixture between wild and cultured conspecifics.
Dorte Bekkevold +4 more
wiley +1 more source
Evaluating Methods for Modeling Epistasis Networks with Application to Head and Neck Cancer
Cancer Informatics, 2015 Epistasis helps to explain how multiple single-nucleotide polymorphisms (SNPs) interact to cause disease. A variety of tools have been developed to detect epistasis.
Rajesh Talluri, Sanjay Shete
doaj +1 more source
Privacy-preserving decision tree for epistasis detection
Cybersecurity, 2019 The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
doaj +1 more source
JMJ720 regulates flowering time in rice via H3K9 demethylation of Hd1
Plant Biotechnology Journal, EarlyView.Summary Heading date is a crucial agronomic trait that determines the adaptability of rice to specific planting regions and seasons. Although numerous heading date genes have been well characterized in rice, epigenetic regulation of flowering time remains limited.
Xiufeng Li +11 more
wiley +1 more source
Epistasis correlates to genomic complexity [PDF]
Proceedings of the National Academy of Sciences, 2006 Whether systematic genetic interactions (epistasis) occur at the genomic scale remains a challenging topic in evolutionary biology. Epistasis should make a significant contribution to variation in complex traits and influence the evolution of genetic systems as sex, diploidy, dominance, or the contamination of genomes with deleterious mutations.
Sanjuán, Rafael, Elena, Santiago F.
openaire +4 more sources
Influence of epistasis on response to genomic selection using complete sequence data
Genetics Selection Evolution, 2017 Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris +3 more
doaj +1 more source
Plant Breeding, EarlyView.ABSTRACT Cucumis melo, a sweet‐tasting fruit from the Cucurbitaceae family, is popular in global markets. While some varieties of C. melo are used for pickling or salads, melons such as cantaloupes and honeydews are consumed as a dessert. Desirable appearance, shelf life and palatability are crucial in determining a variety's success.
Cheyenne G. Cotie +3 more
wiley +1 more source
The Plant Genome, Volume 18, Issue 3, September 2025.Abstract Cacao (Theobroma cacao), the source of chocolate, is threatened by devastating diseases like frosty pod rot (FPR) and witches' broom disease (WBD), impacting global production and farmer livelihoods. Here, we employ a machine learning‐driven genome‐wide association study to dissect the genetic architecture of disease resistance and ...
Ezekiel Ahn +9 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Incomplete understanding of the mechanisms of epistasis between two or more substitutions in a protein can hamper protein-engineering strategies. With Escherichia coli transketolase as a model, we explore the epistatic interactions between a
Haoran Yu, P. Dalby
semanticscholar +1 more source