Results 91 to 100 of about 36,295 (154)
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan +6 more
wiley +1 more source
Universality classes of interaction structures for NK fitness landscapes
, 2018 Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of $L$ binary loci.
Ferretti, Luca +3 more
core +2 more sources
Analysis of Genetic Variation of Rice Straw Characteristics and Its Influence on Biomass
Plant Direct, Volume 10, Issue 1, January 2026.ABSTRACT Rice straw is a key source of lignocellulosic biomass. GWAS can be used to identify genetic loci controlling stem morphological traits that influence biomass. This study aimed to investigate the genotypic diversity of rice straw internodes through GWAS, using 34,232 single‐nucleotide polymorphic sites with a minor allelic frequency (MAF ...
Mahta Mohamadiaza +4 more
wiley +1 more source
A Computational Ecological Genetic Model of Phenotypic Plasticity in Species Interactions
Molecular Ecology Resources, Volume 26, Issue 1, January 2026.ABSTRACT Multiple species respond to each other in their co‐existing communities. Such reciprocal phenotypic plasticity can shape the behaviour and evolution of ecological communities, but its genetic architecture remains elusive. We address this issue by developing a computational mapping model that combines community ecology and quantitative genetics
Yu Wang +5 more
wiley +1 more source
Novel methods for epistasis detection in genome-wide association studies.
PLoS ONE, 2020 More and more genome-wide association studies are being designed to uncover the full genetic basis of common diseases. Nonetheless, the resulting loci are often insufficient to fully recover the observed heritability. Epistasis, or gene-gene interaction,
Lotfi Slim +3 more
doaj +1 more source
How microscopic epistasis and clonal interference shape the fitness trajectory in a spin glass model of microbial long-term evolution [PDF]
, 2023 Nicholas M. Boffi +3 more
openalex +1 more source
Aging Cell, Volume 25, Issue 1, January 2026.hAMSC‐sEVs rejuvenate β cells and improve glycaemic control via the miR‐21‐5p/IL‐6RA/STAT3/MCU axis, restoring mitochondrial Ca2+ homeostasis and insulin secretion in aged T2DM mice. ABSTRACT Targeting senescent pancreatic β‐cells represents a promising therapeutic avenue for age‐related diabetes; however, current anti‐senescence strategies often ...
Lei Xiao +8 more
wiley +1 more source
Journal of Animal Breeding and Genetics, Volume 143, Issue 1, Page 24-34, January 2026.ABSTRACT Genetic progress of breeding programs is highly dependent on the size of reference populations and the relatedness between reference populations and selection candidates. Many reasons can lead a population to split into several subpopulations (sanitary, physiological, political reasons, etc.).
M. Wicki, A. Legarra, J. Raoul
wiley +1 more source
Repeatability of evolution on epistatic landscapes
, 2015 Evolution is a dynamic process. The two classical forces of evolution are mutation and selection. Assuming small mutation rates, evolution can be predicted based solely on the fitness differences between phenotypes.
Bauer, Benedikt, Gokhale, Chaitanya S.
core +1 more source