Results 91 to 100 of about 71,733 (264)

Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model

, 2014
The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume, Bataillon, Thomas, Blanquart, François, Tenaillon, Olivier   +3 more
core   +1 more source

The nk model and population genetics [PDF]

, 2005
The nk model of fitness interactions is examined. This model has been used by previous authors to investigate the effects of fitness epistasis on substitution dynamics in molecular evolution, and to make broader claims about the importance of epistasis ...
Barton, Barton, Bergman, Burch, Coyne, Edmands, Elena, Elena, Felsenstein, Fisher, Fitch, Fontana, Fraser, Gavrilets, Gillespie, Gillespie, Gillespie, Gillespie, Gumbel, Hansen, Hartl, Jeong, Kauffman, Kauffman, Kauffman, Kichler Holder, Kimura, Kimura, Kondrashov, Korona, Lenski, Macken, Mani, Maynard Smith, Moore, Ohta, Ohta, Ohta, Ohta, Orr, Orr, Orr, Peck, Perelson, Phillips, Provine, Schrag, Solow, Stephan, Tachida, Tachida, Weinberger, Welch, Whitlock, Zeng   +54 more
core   +2 more sources

A Low Resolution Epistasis Mapping Approach To Identify Chromosome Arm Interactions in Allohexaploid Wheat

G3: Genes, Genomes, Genetics, 2019
Epistasis is an important contributor to genetic variance. In inbred populations, pairwise epistasis is present as additive by additive interactions.
Nicholas Santantonio, Jean-Luc Jannink, Mark Sorrells   +2 more
doaj   +1 more source

Long-Range Epistasis Mediated by Structural Change in a Model of Ligand Binding Proteins. [PDF]

PLoS ONE, 2016
Recent analyses of amino acid mutations in proteins reveal that mutations at many pairs of sites are epistatic-i.e., their effects on fitness are non-additive-the combined effect of two mutations being significantly larger or smaller than the sum of ...
Erik D Nelson, Nick V Grishin
doaj   +1 more source

Synergistic epistasis among cancer drivers can rescue early tumors from the accumulation of deleterious passengers.

PLoS Computational Biology
Epistasis among driver mutations is pervasive and explains relevant features of cancer, such as differential therapy response and convergence towards well-characterized molecular subtypes.
Carla Alejandre, Jorge Calle-Espinosa, Jaime Iranzo   +2 more
doaj   +1 more source

Historical contingency and entrenchment in protein evolution under purifying selection [PDF]

, 2014
The fitness contribution of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of evolution in populations under selection, and can shape the course of ...
McCandlish, David M., Plotkin, Joshua B., Shah, Premal   +2 more
core   +2 more sources

Influence of epistasis on response to genomic selection using complete sequence data

Genetics Selection Evolution, 2017
Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris, Zulma G. Vitezica, Andres Legarra, Miguel Pérez-Enciso   +3 more
doaj   +1 more source

Dissecting Impacts of Nutrition on Epistasis and Ethnicity-Specific Effects of Calibrated Factor VIII Level in the Multiethnic Study of Atherosclerosis [PDF]

, 2021
Md. Alamin, Jun Zhu, Xiang‐Yang Lou, Haiming Xu   +3 more
openalex   +1 more source

Evolving concurrent Petri net models of epistasis [PDF]

, 2010
A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core   +1 more source

Evaluating Methods for Modeling Epistasis Networks with Application to Head and Neck Cancer

Cancer Informatics, 2015
Epistasis helps to explain how multiple single-nucleotide polymorphisms (SNPs) interact to cause disease. A variety of tools have been developed to detect epistasis.
Rajesh Talluri, Sanjay Shete
doaj   +1 more source