Results 111 to 120 of about 71,733 (264)

Testing the Domino Theory of Gene Loss in Buchnera aphidicola: The Relevance of Epistatic Interactions

Life, 2018
The domino theory of gene loss states that when some particular gene loses its function and cripples a cellular function, selection will relax in all functionally related genes, which may allow for the non-functionalization and loss of these genes.
David J. Martínez-Cano, Gil Bor, Andrés Moya, Luis Delaye   +3 more
doaj   +1 more source

Universality classes of interaction structures for NK fitness landscapes

, 2018
Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of $L$ binary loci.
Ferretti, Luca, Hwang, Sungmin, Krug, Joachim, Schmiegelt, Benjamin   +3 more
core   +2 more sources

Epistasis decreases with increasing antibiotic pressure

, 2023
Ana‐Hermina Ghenu, André Amado, Isabel Gordo, Claudia Bank   +3 more
openalex   +1 more source

Exact Results for Amplitude Spectra of Fitness Landscapes

, 2013
Starting from fitness correlation functions, we calculate exact expressions for the amplitude spectra of fitness landscapes as defined by P.F. Stadler [J. Math. Chem.
Krug, Joachim, Neidhart, Johannes, Szendro, Ivan G.   +2 more
core   +1 more source

Novel methods for epistasis detection in genome-wide association studies.

PLoS ONE, 2020
More and more genome-wide association studies are being designed to uncover the full genetic basis of common diseases. Nonetheless, the resulting loci are often insufficient to fully recover the observed heritability. Epistasis, or gene-gene interaction,
Lotfi Slim, Clément Chatelain, Chloé-Agathe Azencott, Jean-Philippe Vert   +3 more
doaj   +1 more source

The somatic molecular evolution of cancer: Mutation, selection, and epistasis

, 2021
Krishna Dasari, Jason A. Somarelli, Sudhir Kumar, Jeffrey P. Townsend   +3 more
openalex   +1 more source

Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Incomplete understanding of the mechanisms of epistasis between two or more substitutions in a protein can hamper protein-engineering strategies. With Escherichia coli transketolase as a model, we explore the epistatic interactions between a
Haoran Yu, P. Dalby
semanticscholar   +1 more source

Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies

BioData Mining, 2019
Background In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants.
Marc Joiret, Jestinah M. Mahachie John, Elena S. Gusareva, Kristel Van Steen   +3 more
doaj   +1 more source

epistasis

Citation: 'epistasis' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10673 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Divergent Pairwise Epistasis in the Context of Unstable Membrane Protein Variants

, 2023
Laura M. Chamness, Charles P. Kuntz, Andrew G. McKee, Wesley D. Penn, Christopher M. Hemmerich, Douglas B. Rusch, Hope Woods, Dyotima Dyotima, Jens Meiler, Jonathan P. Schlebach   +9 more
openalex   +1 more source