Results 111 to 120 of about 38,773 (257)
Molecular Ecology, Volume 34, Issue 15, August 2025.ABSTRACT Plants adapt to their local environment through complex interactions between genes, gene networks and hormones. Although the impact of gene expression on trait regulation and evolution has been recognised for many decades, its role in the evolution of adaptation is still a subject of intense exploration.
Zoe Broad +7 more
wiley +1 more source
COMPUTING AND INFORMATICS, 2012 Normalized epistasis measures links between separate bits in binary strings. It is used in optimization. Unitarian functions (fitness functions \(f\) whose values depends only upon the number of ones rep. zeros in the optimized binary string) with extreme epistasis are theoretically studied. The epistasis of a binary string \(s = s_{l - 1} \cdots s_0\)
M. T. Iglesias +3 more
openaire +2 more sources
Reconstructability Analysis of Epistasis
Annals of Human Genetics, 2010 The literature on epistasis describes various methods to detect epistatic interactions and to classify different types of epistasis. Reconstructability analysis (RA) has recently been used to detect epistasis in genomic data. This paper shows that RA offers a classification of types of epistasis at three levels of resolution (variable-based models ...
openaire +5 more sources
Genomic Evaluation of Assisted Gene Flow Options in an Endangered Rattlesnake
Molecular Ecology, Volume 34, Issue 16, August 2025.ABSTRACT Assisted gene flow is used to counteract genetic erosion in small populations of endangered species, yet an evaluation of genetic compatibility of potential donor populations and recipient populations is rare. We developed new metrics for assessing the genetic impact of genetic augmentation based on genotype identity of functional variants ...
Samarth Mathur, H. Lisle Gibbs
wiley +1 more source
Life, 2018 The domino theory of gene loss states that when some particular gene loses its function and cripples a cellular function, selection will relax in all functionally related genes, which may allow for the non-functionalization and loss of these genes.
David J. Martínez-Cano +3 more
doaj +1 more source
Modular epistasis and the compensatory evolution of gene deletion mutants
PLoS Genetics, 2019 Screens for epistatic interactions have long been used to characterize functional relationships corresponding to protein complexes, metabolic pathways, and other functional modules.
Jose I. Rojas Echenique +3 more
semanticscholar +1 more source
ChemSusChem, Volume 18, Issue 15, July 27, 2025.Managing synthetic polymer waste is a major challenge. While enzymatic polyamide (PA) hydrolysis holds great recycling potential, it is limited by ineffective polyamidases. The polyamidase NylCp2‐TS is evolved through random mutagenesis and incremental docking, yielding NylC‐HP with enhanced activity and stability.
Hendrik Puetz +6 more
wiley +1 more source
Learning the pattern of epistasis linking genotype and phenotype in a protein
Nature Communications, 2017 Understanding the pattern of epistasis—the non-independence of mutations—is critical for relating genotype and phenotype. However, the combinatorial complexity of potential epistatic interactions has severely limited the analysis of this problem.
F. J. Poelwijk +2 more
semanticscholar +1 more source
BioData Mining, 2019 Background In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants.
Marc Joiret +3 more
doaj +1 more source
THE EFFECT OF EPISTASIS AND GAMETIC UNBALANCE ON GENETIC LOAD [PDF]
, 1966 Paul E. Hansche +2 more
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