Results 11 to 20 of about 38,666 (258)
Global epistasis on fitness landscapes [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2022 Epistatic interactions between mutations add substantial complexity to adaptive landscapes and are often thought of as detrimental to our ability to predict evolution.
Juan Díaz-Colunga +6 more
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Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
Nature Communications, 2023 Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda +2 more
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PLoS Genetics, 2016 Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches depend on information theory.
Kristina Crona
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Epistasis in protein evolution [PDF]
Protein Science, 2016 AbstractThe structure, function, and evolution of proteins depend on physical and genetic interactions among amino acids. Recent studies have used new strategies to explore the prevalence, biochemical mechanisms, and evolutionary implications of these interactions—called epistasis—within proteins.
Tyler N. Starr, J. W. Thornton
semanticscholar +4 more sources
Epistasis and evolution: recent advances and an outlook for prediction
BMC Biology, 2023 As organisms evolve, the effects of mutations change as a result of epistatic interactions with other mutations accumulated along the line of descent. This can lead to shifts in adaptability or robustness that ultimately shape subsequent evolution. Here,
Milo S. Johnson +2 more
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Estimating directional epistasis [PDF]
Frontiers in Genetics, 2014 Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
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Physical constraints on epistasis. [PDF]
Molecular Biology and Evolution, 2019 Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are unclear.
Kabir B Husain, A. Murugan
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Epistasis shapes the fitness landscape of an allosteric specificity switch
Nature Communications, 2021 Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a ...
Kyle K. Nishikawa +4 more
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Inferring the shape of global epistasis [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance How does an organism’s genetic sequence govern its measurable characteristics? New technologies provide libraries of randomized sequences to study this relationship in unprecedented detail for proteins and other molecules.
Jakub Otwinowski +2 more
semanticscholar +5 more sources
Epistasis and Adaptation on Fitness Landscapes [PDF]
Annual Review of Ecology, Evolution and Systematics, 2022 Epistasis occurs when the effect of a mutation depends on its carrier's genetic background. Despite increasing evidence that epistasis for fitness is common, its role during evolution is contentious.
Claudia Bank
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