Results 11 to 20 of about 29,904 (215)
Consequences of Epistasis on Growth in an Erhualian × White Duroc Pig Cross. [PDF]
PLoS ONE, 2017 Epistasis describes an interaction between the effects of loci. We included epistasis in quantitative trait locus (QTL) mapping of growth at a series of ages in a cross of a Chinese pig breed, Erhualian, with a commercial line, White Duroc.
Lucy Crooks, Yuanmei Guo
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Evolutionary footprint of epistasis. [PDF]
PLoS Computational Biology, 2018 Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi +2 more
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Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
Nature Communications, 2023 Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda +2 more
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The impact of epistasis in the heterosis and combining ability analyses
Frontiers in Plant Science, 2023 The current theoretical knowledge concerning the influence of epistasis on heterosis is based on a simplified multiplicative model. The objective of this study was to assess how epistasis affects the heterosis and combining ability analyses, assuming ...
José Marcelo Soriano Viana
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Frontiers in Genetics, 2022 The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da +2 more
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Bulletin of the Belgian Mathematical Society - Simon Stevin, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Iglesias, M. T. +3 more
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Epistasis shapes the fitness landscape of an allosteric specificity switch
Nature Communications, 2021 Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a ...
Kyle K. Nishikawa +4 more
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Physical Constraints on Epistasis [PDF]
Molecular Biology and Evolution, 2020 Abstract Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are unclear. Here, we demonstrate that the physical dynamics of a biological system can generically constrain epistasis.
Husain, Kabir, Murugan, Arvind
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Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
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Hidden epistastic interactions can favour the evolution of sex and recombination. [PDF]
PLoS ONE, 2012 Deleterious mutations can have a strong influence on the outcome of evolution. The nature of this influence depends on how mutations combine together to affect fitness.
Joel R Peck, David Waxman, John J Welch
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