Results 11 to 20 of about 55,446 (204)
The role of epistasis in protein evolution [PDF]
Nature, 2013 Arising from M. S. Breen, C. Kemena, P. K. Vlasov, C. Notredame & F. A. Kondrashov , 535–538 (2012)10.1038/nature11510 An important question in molecular evolution is whether an amino acid that occurs at a given site makes an independent contribution to fitness, or whether its contribution depends ...
Mccandlish, D. M. +4 more
arxiv +8 more sources
Dynamic Epistasis under Varying Environmental Perturbations [PDF]
PLoS ONE 10(1): e0114911, 2014 Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current knowledge for epistatic dynamics under multiple conditions is limited by the technological difficulties in ...
Barker, Brandon, Gu, Zhenglong, Xu, Lin
arxiv +24 more sources
The context-dependence of mutations: a linkage of formalisms [PDF]
, 2015 Defining the extent of epistasis - the non-independence of the effects of mutations - is essential for understanding the relationship of genotype, phenotype, and fitness in biological systems. The applications cover many areas of biological research, including biochemistry, genomics, protein and systems engineering, medicine, and evolutionary biology ...
Krishna, Vinod +2 more
arxiv +13 more sources
GenEpi: gene-based epistasis discovery using machine learning [PDF]
BMC Bioinformatics, 2020 Background Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Yu-Chuan Chang +9 more
doaj +3 more sources
Historical contingency and entrenchment in protein evolution under purifying selection [PDF]
, 2014 The fitness contribution of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of evolution in populations under selection, and can shape the course of protein evolution across divergent species. Whereas epistasis between adaptive substitutions has been the
McCandlish, David M. +2 more
arxiv +4 more sources
Evolutionary footprint of epistasis [PDF]
PLOS Computational Biology, 2018 Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis). Detecting epistasis in genomic data still represents a significant challenge that requires a better understanding of epistasis from the mechanistic point of view.
Gabriele Pedruzzi +2 more
openaire +6 more sources
Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein. [PDF]
PLoS Genetics, 2016 Epistatic interactions between residues determine a protein's adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape.
Aditi Gupta, Christoph Adami
doaj +6 more sources
Estimating directional epistasis [PDF]
Frontiers in Genetics, 2014 Epistasis, i.e., the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to genetic interactions.
Arnaud eLE ROUZIC
openaire +5 more sources
Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1. [PDF]
PLoS ONE, 2011 Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation ...
Javier P Martínez +6 more
doaj +7 more sources
The origin of mutational epistasis [PDF]
European Biophysics JournalThe interconnected processes of protein folding, mutations, epistasis, and evolution have all been the subject of extensive analysis throughout the years due to their significance for structural and evolutionary biology. The origin (molecular basis) of epistasis (the non-additive interactions between mutations) is still, nonetheless, unknown.
openaire +4 more sources