Results 21 to 30 of about 71,733 (264)

Comparison of the Accuracy of Epistasis and Haplotype Models for Genomic Prediction of Seven Human Phenotypes

Biomolecules, 2023
The accuracy of predicting seven human phenotypes of 3657–7564 individuals using global epistasis effects was evaluated and compared to the accuracy of haplotype genomic prediction using 380,705 SNPs and 10-fold cross-validation studies.
Zuoxiang Liang, Dzianis Prakapenka, Yang Da   +2 more
doaj   +1 more source

An extension of the Walsh-Hadamard transform to calculate and model epistasis in genetic landscapes of arbitrary shape and complexity

bioRxiv, 2023
Accurate models describing the relationship between genotype and phenotype are necessary in order to understand and predict how mutations to biological sequences affect the fitness and evolution of living organisms.
André J. Faure, Ben Lehner, V. Miró Pina, Claudia Serrano Colomé, Donate Weghorn   +4 more
semanticscholar   +1 more source

Environmental modulation of global epistasis in a drug resistance fitness landscape

Nature Communications, 2023
Interactions between mutations (epistasis) can add substantial complexity to genotype-phenotype maps, hampering our ability to predict evolution. Yet, recent studies have shown that the fitness effect of a mutation can often be predicted from the fitness
Juan Díaz-Colunga, Álvaro Sánchez, C. B. Ogbunugafor   +2 more
semanticscholar   +1 more source

PyToxo: a Python tool for calculating penetrance tables of high-order epistasis models

BMC Bioinformatics, 2022
Background Epistasis is the interaction between different genes when expressing a certain phenotype. If epistasis involves more than two loci it is called high-order epistasis. High-order epistasis is an area under active research because it could be the
Borja González-Seoane, Christian Ponte-Fernández, Jorge González-Domínguez, María J. Martín   +3 more
doaj   +1 more source

Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1

bioRxiv, 2022
The Omicron BA.1 variant emerged in late 2021 and quickly spread across the world. Compared to the ancestral Wuhan Hu-1 strain and other pre-Omicron SARS-CoV-2 variants, BA.1 has many mutations, a number of which are known to enable antibody escape 1–3 ...
Alief Moulana, T. Dupic, Angela M. Phillips, Jeffrey Chang, Serafina Nieves, Anne A. Roffler, Allison J. Greaney, Tyler N. Starr, J. Bloom, Michael M. Desai   +9 more
semanticscholar   +1 more source

Evolutionary accessibility of mutational pathways [PDF]

, 2011
Functional effects of different mutations are known to combine to the total effect in highly nontrivial ways. For the trait under evolutionary selection (`fitness'), measured values over all possible combinations of a set of mutations yield a fitness ...
de Visser, J. Arjan G. M., Franke, Jasper, Klözer, Alexander, Krug, Joachim   +3 more
core   +11 more sources

Consequences of Epistasis on Growth in an Erhualian × White Duroc Pig Cross. [PDF]

PLoS ONE, 2017
Epistasis describes an interaction between the effects of loci. We included epistasis in quantitative trait locus (QTL) mapping of growth at a series of ages in a cross of a Chinese pig breed, Erhualian, with a commercial line, White Duroc.
Lucy Crooks, Yuanmei Guo
doaj   +1 more source

Factorizing polygenic epistasis improves prediction and uncovers biological pathways in complex traits

bioRxiv, 2023
Epistasis is central in many domains of biology, but it has not yet proven useful for complex traits. This is partly because complex trait epistasis involves polygenic interactions that are poorly captured in current models.
David Tang, Jerome Freudenberg, Andy Dahl   +2 more
semanticscholar   +1 more source

Evolutionary footprint of epistasis. [PDF]

PLoS Computational Biology, 2018
Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi, Ayuna Barlukova, Igor M Rouzine   +2 more
doaj   +1 more source

Nested epistasis enhancer networks for robust genome regulation

Science, 2022
Mammalian genomes have multiple enhancers spanning an ultralong distance (>megabases) to modulate important genes, but it is unclear how these enhancers coordinate to achieve this task.
Xueqiu Lin, Yanxia Liu, Shuai Liu, Xiang Zhu, Lingling Wu, Yanyu Zhu, Dehua Zhao, Xiaoshu Xu, Augustine Chemparathy, Haifeng Wang, Yaqiang Cao, Muneaki Nakamura, J. N. Noordermeer, Marie La Russa, Wing Hong Wong, K. Zhao, Lei S. Qi   +16 more
semanticscholar   +1 more source