Results 21 to 30 of about 36,295 (154)

Epistasis shapes the fitness landscape of an allosteric specificity switch

open access: yesNature Communications, 2021
Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a ...
Kyle K. Nishikawa   +4 more
doaj   +1 more source

Hidden epistastic interactions can favour the evolution of sex and recombination. [PDF]

open access: yesPLoS ONE, 2012
Deleterious mutations can have a strong influence on the outcome of evolution. The nature of this influence depends on how mutations combine together to affect fitness.
Joel R Peck, David Waxman, John J Welch
doaj   +1 more source

Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease

open access: yesScientific Reports, 2022
Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang   +9 more
doaj   +1 more source

Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]

open access: yes, 2013
John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D   +2 more
core   +1 more source

Detecting epistasis via Markov bases [PDF]

open access: yes, 2010
Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
core   +1 more source

Parallel and serial computing tools for testing single-locus and epistatic SNP effects of quantitative traits in genome-wide association studies

open access: yesBMC Bioinformatics, 2008
Background Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers provide opportunities to detect epistatic SNPs associated with quantitative traits and to detect the exact mode of an epistasis effect.
Garbe John R   +4 more
doaj   +1 more source

Dynamic network-based epistasis analysis: Boolean examples

open access: yesFrontiers in Plant Science, 2011
In this review we focus on how the hierarchical and single-path assumptions of epistasis analysis can bias the topologies of gene interactions infered. This has been acknowledged in several previous papers and reviews, but here we emphasize the critical ...
Eugenio eAzpeitia   +5 more
doaj   +1 more source

Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders

open access: yesFrontiers in Immunology, 2018
The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes ...
Rohan Ameratunga   +9 more
doaj   +1 more source

Epistasis not needed to explain low dN/dS

open access: yes, 2012
An important question in molecular evolution is whether an amino acid that occurs at a given position makes an independent contribution to fitness, or whether its effect depends on the state of other loci in the organism's genome, a phenomenon known as ...
AL Halpern   +19 more
core   +1 more source

Towards a Better Basis Search through a Surrogate Model-Based Epistasis Minimization for Pseudo-Boolean Optimization

open access: yesMathematics, 2020
Epistasis, which indicates the difficulty of a problem, can be used to evaluate the basis of the space in which the problem lies. However, calculating epistasis may be challenging as it requires all solutions to be searched.
Yong-Hoon Kim   +2 more
doaj   +1 more source

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