Results 21 to 30 of about 38,666 (258)

Epistasis in Monkeyflowers [PDF]

Genetics, 2005
AbstractEpistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the
John K. Kelly
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Dominance and Epistasis [PDF]

Poultry Science, 1958
Elliot Kimball
openalex   +2 more sources

Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1

bioRxiv, 2022
The Omicron BA.1 variant emerged in late 2021 and quickly spread across the world. Compared to the ancestral Wuhan Hu-1 strain and other pre-Omicron SARS-CoV-2 variants, BA.1 has many mutations, a number of which are known to enable antibody escape 1–3 ...
Alief Moulana, T. Dupic, Angela M. Phillips, Jeffrey Chang, Serafina Nieves, Anne A. Roffler, Allison J. Greaney, Tyler N. Starr, J. Bloom, Michael M. Desai   +9 more
semanticscholar   +1 more source

Considerations in the search for epistasis. [PDF]

Genome Biol
Abstract Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive ...
Balvert M, Cooper-Knock J, Stamp J, Byrne RP, Mourragui S, van Gils J, Benonisdottir S, Schlüter J, Kenna K, Abeln S, Iacoangeli A, Daub JT, Browning BL, Taş G, Hu J, Wang Y, Alhathli E, Harvey C, Pianesi L, Schulte SC, González-Domínguez J, Garrisson E, Lorentz workshop on epistasis, Snyder MP, Schönhuth A, Sng LMF, Twine NA.   +26 more
europepmc   +6 more sources

Nested epistasis enhancer networks for robust genome regulation

Science, 2022
Mammalian genomes have multiple enhancers spanning an ultralong distance (>megabases) to modulate important genes, but it is unclear how these enhancers coordinate to achieve this task.
Xueqiu Lin, Yanxia Liu, Shuai Liu, Xiang Zhu, Lingling Wu, Yanyu Zhu, Dehua Zhao, Xiaoshu Xu, Augustine Chemparathy, Haifeng Wang, Yaqiang Cao, Muneaki Nakamura, J. N. Noordermeer, Marie La Russa, Wing Hong Wong, K. Zhao, Lei S. Qi   +16 more
semanticscholar   +1 more source

The causes of epistasis [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2011
Since Bateson's discovery that genes can suppress the phenotypic effects of other genes, gene interactions—called epistasis—have been the topic of a vast research effort. Systems and developmental biologists study epistasis to understand the genotype–phenotype map, whereas evolutionary biologists recognize the fundamental importance of epistasis for ...
De Visser, J., Cooper, Tim F., Elena, Santiago F., Arjan, G. M.   +3 more
openaire   +5 more sources

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

bioRxiv, 2022
Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has generated affinity matured B cells, producing broadly neutralizing receptor ...
Leander Witte, Viren A. Baharani, F. Schmidt, Zijun Wang, A. Cho, Raphael Raspe, Camila Guzmán-Cardozo, F. Muecksch, Marie Canis, Debby J. Park, C. Gaebler, M. Caskey, M. Nussenzweig, T. Hatziioannou, P. Bieniasz   +14 more
semanticscholar   +1 more source

Dominance, codominance and epistasis

Brazilian Journal of Genetics, 1997
W.J. Miller
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Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

mBio, 2022
Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide.
N. Rochman, Guilhem Faure, Y. Wolf, Lydia Freddolino, Feng Zhang, E. Koonin   +5 more
semanticscholar   +1 more source

Q&A: Epistasis [PDF]

Journal of Biology, 2009
Epistasis under the classical definition describes only interactions in which one mutant phenotype is masked or suppressed in the presence of the other mutation. The population geneticist's definition includes classical epistasis, but also encompasses 'aggravating' or 'synthetic' interactions – where two mutations together yield a surprisingly ...
Roth, Fritz, Lipshitz, Howard D, Andrews, Brenda J   +2 more
openaire   +4 more sources