Results 21 to 30 of about 55,446 (204)
Global epistasis emerges from a generic model of a complex trait
eLife, 2021 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
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Emergence and propagation of epistasis in metabolic networks
eLife, 2021 Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
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High-order epistasis shapes evolutionary trajectories. [PDF]
PLoS Computational Biology, 2017 High-order epistasis-where the effect of a mutation is determined by interactions with two or more other mutations-makes small, but detectable, contributions to genotype-fitness maps. While epistasis between pairs of mutations is known to be an important
Zachary R Sailer, Michael J Harms
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A network model for the correlation between epistasis and genomic complexity. [PDF]
PLoS ONE, 2008 The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is ...
Rafael Sanjuán, Miguel R Nebot
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Biomolecules, 2023 The accuracy of predicting seven human phenotypes of 3657–7564 individuals using global epistasis effects was evaluated and compared to the accuracy of haplotype genomic prediction using 380,705 SNPs and 10-fold cross-validation studies.
Zuoxiang Liang +2 more
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Consequences of Epistasis on Growth in an Erhualian × White Duroc Pig Cross. [PDF]
PLoS ONE, 2017 Epistasis describes an interaction between the effects of loci. We included epistasis in quantitative trait locus (QTL) mapping of growth at a series of ages in a cross of a Chinese pig breed, Erhualian, with a commercial line, White Duroc.
Lucy Crooks, Yuanmei Guo
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PyToxo: a Python tool for calculating penetrance tables of high-order epistasis models
BMC Bioinformatics, 2022 Background Epistasis is the interaction between different genes when expressing a certain phenotype. If epistasis involves more than two loci it is called high-order epistasis. High-order epistasis is an area under active research because it could be the
Borja González-Seoane +3 more
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The impact of epistasis in the heterosis and combining ability analyses
Frontiers in Plant Science, 2023 The current theoretical knowledge concerning the influence of epistasis on heterosis is based on a simplified multiplicative model. The objective of this study was to assess how epistasis affects the heterosis and combining ability analyses, assuming ...
José Marcelo Soriano Viana
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Resolving discrepancies between chimeric and multiplicative measures of higher-order epistasis. [PDF]
Nat CommunEpistasis - the interaction between alleles at different genetic loci - plays a fundamental role in biology. However, several recent approaches quantify epistasis using a chimeric formula that measures deviations from a multiplicative fitness model on an
Chitra U, Arnold B, Raphael BJ.
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Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
Nature Communications, 2023 Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis.
Karol Buda +2 more
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