Results 21 to 30 of about 324,947 (241)

Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. [PDF]

PLoS ONE, 2014
Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition.
Evelyn Zeindl-Eberhart, Lydia Brandl, Sibylle Liebmann, Steffen Ormanns, Silvio K Scheel, Thomas Brabletz, Thomas Kirchner, Andreas Jung   +7 more
doaj   +1 more source

Metabolic Plasticity and Epithelial-Mesenchymal Transition [PDF]

Journal of Clinical Medicine, 2019
A major transcriptional and phenotypic reprogramming event during development is the establishment of the mesodermal layer from the ectoderm through epithelial-mesenchymal transition (EMT). EMT is employed in subsequent developmental events, and also in many physiological and pathological processes, such as the dissemination of cancer cells through ...
Marta Cascante, Marta Cascante, Timothy M. Thomson, Cristina Balcells   +3 more
openaire   +5 more sources

Epithelial-Mesenchymal Transitions in Development and Disease [PDF]

Cell, 2009
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms.
Hervé Acloque, Jean Paul Thiery, Jean Paul Thiery, Ruby Yun-Ju Huang, Ruby Yun-Ju Huang, M. Angela Nieto   +5 more
openaire   +6 more sources

Clinical significance of epithelial‐mesenchymal transition [PDF]

Clinical and Translational Medicine, 2014
AbstractThe concept of epithelial‐mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research community. Thousands of scientific reports investigated changes in gene, mRNA and protein expression compatible with EMT and their possible ...
Julie Steinestel, Konrad Steinestel, Andres Jan Schrader, Stefan Eder   +3 more
openaire   +4 more sources

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites [PDF]

, 2017
Background: During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma.
Carletti, R, Chiappetta, C, Cortesi, E, Di Gioia, C., Mezi, S, Nardini, A, Orsi, E, Piesco, G   +7 more
core   +1 more source

Epithelial-mesenchymal transition [PDF]

Journal of Cell Science, 2005
The epithelial-mesenchymal transition (EMT) is an orchestrated series of events in which cell-cell and cell-extracellular matrix (ECM) interactions are altered to release epithelial cells from the surrounding tissue, the cytoskeleton is reorganized to confer the ability to move through a three-
openaire   +3 more sources

Epithelial–Mesenchymal Transition in Ovarian Carcinoma [PDF]

Frontiers in Oncology, 2012
Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is attributed to diagnosis at advanced stage, when the tumor has metastasized, and to chemotherapy resistance, either primary or developing along tumor progression ...
Reuven Reich, Claes G. Tropé, Ben Davidson   +2 more
openaire   +3 more sources

Emerging roles of epithelial-mesenchymal transition in hematological malignancies

Journal of Biomedical Science, 2018
Background Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with ...
San-Chi Chen, Tsai-Tsen Liao, Muh-Hwa Yang   +2 more
doaj   +1 more source

Mesenchymal Stromal Cells Epithelial Transition Induced by Renal Tubular Cells-Derived Extracellular Vesicles. [PDF]

PLoS ONE, 2016
Mesenchymal-epithelial interactions play an important role in renal tubular morphogenesis and in maintaining the structure of the kidney. The aim of this study was to investigate whether extracellular vesicles (EVs) produced by human renal proximal ...
Giulia Chiabotto, Stefania Bruno, Federica Collino, Giovanni Camussi   +3 more
doaj   +1 more source

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source