Results 81 to 90 of about 324,947 (241)

Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes [PDF]

, 2017
The microgravitational environment is known to affect the cellular behaviour inducing modulation of gene expression and enzymatic activities, epigenetic modifications and alterations of the structural organization. Simulated microgravity, obtained in the
Bizzarri, Mariano, Catizone, Angiolina, Cucina, Alessandra, Dinicola, Simona, Masiello, Maria Grazia, Proietti, Sara, Ranieri, Danilo, Ricci, Giulia, Rosato, Benedetta, Torrisi, Maria Rosaria   +9 more
core   +1 more source

Transcriptional regulation of epithelial-mesenchymal transition [PDF]

Journal of Clinical Investigation, 2007
It has become increasingly obvious that the notion of a terminally differentiated cell is likely a simplified concept. Epithelial-mesenchymal transition (EMT), during which epithelial cells assume a mesenchymal phenotype, is a key event occurring during normal development and pathological processes.
Teng, Yingqi, Zeisberg, Michael, Kalluri, Raghu   +2 more
openaire   +3 more sources

Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy

Frontiers in Oncology, 2020
Metabolic reprogramming and epithelial-mesenchymal plasticity are both hallmarks of the adaptation of cancer cells for tumor growth and progression. For metabolic changes, cancer cells alter metabolism by utilizing glucose, lipids, and amino acids to ...
Nai-Yun Sun, Nai-Yun Sun, Muh-Hwa Yang, Muh-Hwa Yang, Muh-Hwa Yang   +4 more
doaj   +1 more source

BDNF/TrkB axis activation promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis [PDF]

, 2017
Background: Neurotrophins (NT) belongs to a family of growth factors which promotes neurons survival and differentiation. Increasing evidence show that NT and their receptor are expressed in lung tissues suggesting a possible role in lung health and ...
Bruno, Pierdonato, Cardillo, Giuseppe, Cherubini, Emanuela, D'Ascanio, Michela, Mancini, Rita, Mariotta, Salvatore, Osman, GIORGIA AMIRA, Ricci, Alberto, Scozzi, Davide   +8 more
core   +1 more source

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal [PDF]

, 2018
Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases.
Battistelli, Cecilia, Bordoni, Veronica, DE TURRIS, Valeria, Domenici, Alessandro, Mai, Antonello, Manzione, Andrea, Mene', Paolo, Moioli, Alessandra, Noce, Valeria, Palladino, Marco, Rossi, Lucia, Strippoli, Raffaele, Tripodi, Marco, Valente, Sergio, Zwergel, Clemens   +14 more
core   +1 more source

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation [PDF]

, 2016
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful.
Bellomo, C, Bickle, M, Carthy, JM, Gahman, TC, Heldin, A, Heldin, CH, Kardassis, D, Morén, A, Moustakas, A, Shiau, AK, Stöter, M, Vanlandewijck, M, Zerial, M   +12 more
core   +1 more source

Epithelial-Mesenchymal Transition and Breast Cancer [PDF]

Journal of Clinical Medicine, 2016
Breast cancer is the most common cancer in women and distant site metastasis is the main cause of death in breast cancer patients. There is increasing evidence supporting the role of epithelial-mesenchymal transition (EMT) in tumor cell progression, invasion, and metastasis.
Jaydutt V. Vadgama, Yanyuan Wu, Marianna Sarkissyan   +2 more
openaire   +3 more sources

MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney tubules, renal vesicles, comma- and s-shaped bodies in human kidney

European Journal of Histochemistry, 2012
MUC1 is a transmembrane glycoprotein, apically expressed in most epithelial cells, used in the differential diagnosis of carcinomas and for discrimination of tumors of non-epithelial origin showing epithelioid features.
V. Fanos, G. Faa, S. Mellou, G. Monga, P. Van Eyken, S. Nemolato, C. Gerosa, A. Locci, N. Iacovidou, D. Fanni   +9 more
doaj   +2 more sources

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution. [PDF]

, 2019
Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on cancer progression and drug resistance.
Anchang, Benedict, Bendall, Sean C, Benson, Jalen A, Ignatiadis, Nikolaos, Karacosta, Loukia G, Kimmey, Samuel C, Plevritis, Sylvia K, Shrager, Joseph B, Tibshirani, Robert   +8 more
core  

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. [PDF]

, 2016
The epithelial-mesenchymal transition (EMT) endows carcinoma cells with phenotypic plasticity that can facilitate the formation of cancer stem cells (CSCs) and contribute to the metastatic cascade.
Banno, Asoka, Bui, Jack D, Chang, Aaron N, Chang, John T, Fisch, Kathleen, Florea, Bogdan I, Garcia, Daniel A, Geurink, Paul P, Kim, Stephanie H, Lopez, Justine, Metz, Patrick J, Ovaa, Huib, Overkleeft, Hermen S, van Baarsel, Eric D, Widjaja, Christella E, Yang, Jing   +15 more
core   +2 more sources