Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives [PDF]
Antonio Díaz-López,1 Gema Moreno-Bueno,1,2 Amparo Cano11Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM ...
Díaz-López A +2 more
doaj +2 more sources
Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma
Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer ...
Carla Cano +2 more
doaj +3 more sources
Mechanochemical alterations in lung cells during fibrogenesis [PDF]
Màster en BiofísicaIdiopath pulmonary fibrosis (IPF) is a usually fatal disease associated with hardening of the lung tissue, epithelial injury and abnormal wound healing.
Pavelescu, Irina
core +6 more sources
Epithelial‐to‐mesenchymal transitions in the liver† [PDF]
The outcome of liver injury is dictated by the effectiveness of repair. Successful repair (i.e., regeneration) results in replacement of dead epithelial cells with healthy epithelial cells, and reconstructs normal hepatic structure and function. Liver regeneration is known to involve replication of surviving mature hepatocytes and bile duct cells. This
Steve S, Choi, Anna Mae, Diehl
openaire +2 more sources
Vitamin D and the Epithelial to Mesenchymal Transition [PDF]
Several studies support reciprocal regulation between the active vitamin D derivative 1α,25‐dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and ...
Larriba, María Jesús +2 more
openaire +5 more sources
Arginine methylation in the epithelial‐to‐mesenchymal transition [PDF]
Epithelial cells acquire mesenchymal characteristics during embryonic development, wound healing, fibrosis, and in cancer in a processed termed epithelial‐to‐mesenchymal transition (EMT). Regulatory networks of EMT are controlled by post‐transcriptional, translational, and post‐translational mechanisms, in which arginine methylation is critically ...
Jian Qin, Jian Xu
openaire +2 more sources
TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core +1 more source
The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy [PDF]
Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of tubulointerstitial fibrosis is epithelial-to-mesenchymal transition ...
Hills, Claire E. +3 more
core +1 more source
The Epithelial-to-Mesenchymal Transition in Cancer [PDF]
The epithelial-to-mesenchymal transition (EMT) occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing.[...]
openaire +2 more sources
Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma
The epithelial to mesenchymal transition (EMT) is a cellular process that has been linked to the promotion of aggressive cellular features in many cancer types. It is characterized by the loss of the epithelial cell phenotype and a shift to a more mesenchymal phenotype and is accompanied by an associated change in cell markers.
Kristin Hinton +3 more
openaire +3 more sources

