Results 11 to 20 of about 207,488 (262)
The Epithelial-to-Mesenchymal Transition in Cancer [PDF]
Cancers, 2018 The epithelial-to-mesenchymal transition (EMT) occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing.[...]
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Emerging roles of epithelial-mesenchymal transition in hematological malignancies
Journal of Biomedical Science, 2018 Background Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with ...
San-Chi Chen +2 more
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Mesenchymal Stem Cell-Like Properties in Fibroblasts
Cellular Physiology and Biochemistry, 2014 Fibroblasts are biologically dynamic and morphologically heterogeneous and are the most abundant connective tissue cells, with diverse structures depending on their location and activity.
Yuqiao Chang, He Li, Zhikun Guo
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MicroRNA Regulation of Epithelial to Mesenchymal Transition [PDF]
Journal of Clinical Medicine, 2016 Epithelial to mesenchymal transition (EMT) is a central regulatory program that is similar in many aspects to several steps of embryonic morphogenesis. In addition to its physiological role in tissue repair and wound healing, EMT contributes to chemo resistance, metastatic dissemination and fibrosis, amongst others.
Mohammed Abba +3 more
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Epithelial to Mesenchymal Transition in a Clinical Perspective [PDF]
Journal of Oncology, 2015 Tumor growth and metastatic dissemination rely on cellular plasticity. Among the different phenotypes acquired by cancer cells, epithelial to mesenchymal transition (EMT) has been extensively illustrated. Indeed, this transition allows an epithelial polarized cell to acquire a more mesenchymal phenotype with increased mobility and invasiveness.
Jennifer Pasquier +3 more
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TGF-β and epithelial-to-mesenchymal transitions [PDF]
Oncogene, 2005 Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular mediators that control epithelial plasticity will be required in order to develop viable therapeutic approaches targeting epithelial-to-mesenchymal transition (EMT), an ...
Jiri, Zavadil, Erwin P, Böttinger
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Particle and Fibre Toxicology, 2023 Chronic exposure to silica can lead to silicosis, one of the most serious occupational lung diseases worldwide, for which there is a lack of effective therapeutic drugs and tools.
Shaoqi Yang +10 more
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Induction and Analysis of Epithelial to Mesenchymal Transition [PDF]
Journal of Visualized Experiments, 2013 Epithelial to mesenchymal transition (EMT) is essential for proper morphogenesis during development. Misregulation of this process has been implicated as a key event in fibrosis and the progression of carcinomas to a metastatic state. Understanding the processes that underlie EMT is imperative for the early diagnosis and clinical control of these ...
Yixin, Tang +4 more
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Epithelial‐to‐mesenchymal‐like transition events in melanoma [PDF]
The FEBS Journal, 2021 Epithelial‐to‐mesenchymal transition (EMT), a process through which epithelial tumor cells acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination and therapy resistance in cancer. Accumulating evidence indicates that nonepithelial tumors, including melanoma, can also gain mesenchymal‐like properties that increase their ...
Pedri, Dennis +4 more
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Protons sensitize epithelial cells to mesenchymal transition. [PDF]
PLoS ONE, 2012 Proton radiotherapy has gained more favor among oncologists as a treatment option for localized and deep-seated tumors. In addition, protons are a major constituent of the space radiation astronauts receive during space flights.
Minli Wang +5 more
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