Results 21 to 30 of about 87,270,183 (304)
An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer [PDF]
, 2011 The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility.
Richard R. Meehan +28 more
core +1 more source
HMGB-1 - a novel mediator of inflammatory-induced renal epithelial mesenchymal transition [PDF]
, 2010 Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has ...
Ryan, Michael P. +11 more
core +1 more source
Hepatic regeneration and the epithelial to mesenchymal transition [PDF]
World Journal of Gastroenterology, 2013 Liver injuries are repaired by fibrosis and regeneration. The core stage is the repair response and fibrosis formation as a scar. The cause of overly-responsive scar formation and diminished regeneration, especially in liver fibrosis and cirrhosis, is still unknown.
Xue, Zeng-Fu, Wu, Xiu-Min, Liu, Ming
openaire +3 more sources
Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition [PDF]
, 2013 Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastatic ...
Adam I. Marcus +39 more
core +2 more sources
Human Cancer Cells Express Slug-based Epithelial-Mesenchymal Transition Gene Signature Obtained in Vivo [PDF]
, 2011 The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT).
Rumjantseva Viktoria +24 more
core +2 more sources
Epithelial‐to‐mesenchymal‐like transition events in melanoma [PDF]
The FEBS Journal, 2021 Epithelial‐to‐mesenchymal transition (EMT), a process through which epithelial tumor cells acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination and therapy resistance in cancer. Accumulating evidence indicates that nonepithelial tumors, including melanoma, can also gain mesenchymal‐like properties that increase their ...
Pedri, Dennis +4 more
openaire +4 more sources
TGF-β and epithelial-to-mesenchymal transitions [PDF]
Oncogene, 2005 Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular mediators that control epithelial plasticity will be required in order to develop viable therapeutic approaches targeting epithelial-to-mesenchymal transition (EMT), an ...
Jiri, Zavadil, Erwin P, Böttinger
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Induction and Analysis of Epithelial to Mesenchymal Transition [PDF]
Journal of Visualized Experiments, 2013 Epithelial to mesenchymal transition (EMT) is essential for proper morphogenesis during development. Misregulation of this process has been implicated as a key event in fibrosis and the progression of carcinomas to a metastatic state. Understanding the processes that underlie EMT is imperative for the early diagnosis and clinical control of these ...
Yixin, Tang +4 more
openaire +2 more sources
Epithelial to mesenchymal transition and breast cancer [PDF]
Breast Cancer Research, 2009 Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site.
Tomaskovic-Crook, Eva +2 more
openaire +3 more sources
H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma
Cellular Physiology and Biochemistry, 2018 Background/Aims: Glioma is one of the most devasting tumors and confers dismal prognosis. Long noncoding RNAs(lncRNAs) have emerged as important regulators in various tumors including glioma. A classic lncRNA-H19, which is found to be highly expressed in
Qi Hu +6 more
doaj +1 more source