Results 221 to 230 of about 428,265 (254)

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Epithelial Barrier Function and Altered Cell Signaling Pathways in the Esophageal Epithelium of Achalasia Patients. [PDF]

Turk J Gastroenterol
Kipcak S, Ergun P, Gunel NS, Bor S.
europepmc   +1 more source

Genome‐Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of Diaphorina citri to the Citrus Greening Pathogen, Candidatus Liberibacter Asiaticus

Advanced Science, EarlyView.
This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu, Qingcui He, Zeyue Lin, Shixuan Huang, Zichun Zhong, Pingyang Zhu, Mengge Gao, Luyao Zhao, Han Jin, Guiting Wu, Gurr M. Geoff, Qunxin Han, Rui Pang   +12 more
wiley   +1 more source

Oral Microcapsules Encapsulating Endometrial Regenerative Cell-Derived Exosomes Promote Intestinal Epithelial Barrier Repair and Ameliorate Experimental Colitis. [PDF]

Int J Nanomedicine
Yang GM, Jiang HY, Ren SH, Xu YN, Wang HD, Shao B, Chen Q, Xiao YY, Sun CL, Liu X, Ren YF, Wang H.   +11 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Effects of psychosocial stress on laryngeal microbiology and epithelial barrier integrity. [PDF]

Sci Rep
Venkatraman A, Jacobs K, Binns J, An R, Rey F, Thibeault SL.   +5 more
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

HMGB1 impairs nasal mucosa epithelial barrier function in allergic rhinitis by promoting BECN1-mediating autophagy. [PDF]

Biochem Biophys Rep
Ma Z, Tu L, Yang X, Mao M, Chen G, Chen F, Liao L, Xu Y.   +7 more
europepmc   +1 more source

Periplaneta americana extract ameliorates recurrent oral ulcers in rats by enhancing the intestinal epithelial barrier and regulating gut microbiota. [PDF]

PLoS One
Li K, Yuan L, Zhang J, Li W, Zhao G, Chen Z, Yang Y, He Z, Xiao P.   +8 more
europepmc   +1 more source

Loss of Intestinal Endosome-associated Protein Sorting Nexin 27 Disrupts Epithelial Barrier and Promotes Inflammation. [PDF]

Cell Mol Gastroenterol Hepatol
Deb S, Zhang Y, An Y, Xia Y, Sun J.
europepmc   +1 more source