Results 271 to 280 of about 2,478,278 (345)

HIV-associated penile anaerobes disrupt epithelial barrier integrity. [PDF]

PLoS Pathog
Buchanan LB, Shao Z, Galiwango RM, Constable S, Zuanazzi D, Biribawa VM, Ssemunywa HR, Namuniina A, Okech B, Edfeldt G, Tjernlund A, Tobian AAR, Park DE, Pham T, Aziz M, Salazar JE, Nelson S, Liu CM, Kaul R, Prodger JL.   +19 more
europepmc   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage. [PDF]

Science
Hoagland DA, Rodríguez-Morales P, Mann AO, Baez Vazquez AY, Yu S, Lai A, Kane H, Dang SM, Lin Y, Thorens L, Begum S, Castro MA, Pope SD, Lim J, Li S, Zhang X, Li MO, Kim CF, Jackson R, Medzhitov R, Franklin RA.   +20 more
europepmc   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

An Antioxidative Exopolysaccharide-Protein Complex of <i>Cordyceps</i> Cs-HK1 Fungus and Its Epithelial Barrier-Protective Effects in Caco-2 Cell Culture. [PDF]

Antioxidants (Basel)
Zhu YY, Wu MMH, Zhao ZC, Gu FT, Huang LX, Kwok KWH, Wu JY.   +6 more
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

RGS1 induces nasal epithelial barrier dysfunction in allergic rhinitis by modulating NF-κB/AQP5 axis. [PDF]

Cytotechnology
Chang W, He Y, Liu L.
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases. [PDF]

FEBS Lett
Zeyneloglu C, Babayev H, Ogulur I, Ardicli S, Pat Y, Yazici D, Zhao B, Chang L, Liu X, D'Avino P, Li M, Biçer C, Kurtoğlu Babayev FH, Dhir R, Nadeau KC, Brüggen MC, Akdis M, Akdis CA.   +17 more
europepmc   +1 more source

The Microbial Metabolite δ-Valerobetaine Strengthens the Gut Epithelial Barrier. [PDF]

Am J Pathol
Askew LC, Gacasan CA, Barbian ME, Weinberg J, Luo L, Robinson BS, Jones DP, Scharer CD, Jones RM.   +8 more
europepmc   +1 more source