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Oral Mucosal Epithelial Cells [PDF]

open access: yesFrontiers in Immunology, 2019
Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the organism from chemical, microbial, and physical challenges which is indispensable for viability.
Sabine Groeger, Joerg Meyle
doaj   +4 more sources

Thymic Epithelial Cells

open access: yesAnnual Review of Immunology, 2017
Intrathymic T cell development is a complex process that depends upon continuous guidance from thymus stromal cell microenvironments. The thymic epithelium within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenotypic, and functional heterogeneity.
Abramson, Jakub, Anderson, Graham
openaire   +3 more sources

Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling [PDF]

open access: yesCell Reports, 2018
Summary: Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest.
Chengkang Zhang   +7 more
doaj   +3 more sources

Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut

open access: yesCells, 2021
Cytokines are small proteins that are secreted by a vast majority of cell types in the gut. They not only establish cell-to-cell interactions and facilitate cellular signaling, but also regulate both innate and adaptive immune responses, thereby playing ...
Mousumi Mahapatro, L. Erkert, C. Becker
semanticscholar   +1 more source

Modeling Gastrointestinal Diseases Using Organoids to Understand Healing and Regenerative Processes

open access: yesCells, 2021
The gastrointestinal tract is a continuous series of organs from the mouth to the esophagus, stomach, intestine and anus that allows digestion to occur.
Alexane Ollivier   +2 more
doaj   +1 more source

A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

open access: yesNature Communications, 2021
Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contribute ...
Louciné Mitoyan   +10 more
doaj   +1 more source

Production of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors

open access: yesSTAR Protocols, 2023
Summary: Primary human mammary epithelial cells (pHMECs) are known to be remarkably difficult to engineer genetically. Here, we present a protocol for efficient transduction of pHMECs using a baboon retroviral envelope glycoprotein for pseudotyping of ...
Sonia Pastor   +5 more
doaj   +1 more source

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

open access: yesInternational Journal of Oral Science, 2020
It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection.
Hao Xu   +7 more
semanticscholar   +1 more source

BMI1 nuclear location is critical for RAD51-dependent response to replication stress and drives chemoresistance in breast cancer stem cells

open access: yesCell Death and Disease, 2022
Replication stress (RS) has a pivotal role in tumor initiation, progression, or therapeutic resistance. In this study, we depicted the mechanism of breast cancer stem cells’ (bCSCs) response to RS and its clinical implication.
Violette Azzoni   +20 more
doaj   +1 more source

From Submerged Cultures to 3D Cell Culture Models: Evolution of Nasal Epithelial Cells in Asthma Research and Virus Infection

open access: yesViruses, 2021
Understanding the response to viral infection in the context of respiratory diseases is of significant importance. Recently, there has been more focus on the role of the nasal epithelium in disease modeling.
Malik Aydin   +10 more
doaj   +1 more source

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