IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells. [PDF]
PLoS ONE, 2018 Alveolar epithelial cells are critical to the pathogenesis of pulmonary inflammation and fibrosis, which are associated with overexpression of type 2 cytokine IL-13.
Yoko Ito +7 more
doaj +1 more source
Nasal epithelial cells can act as a physiological surrogate for paediatric asthma studies. [PDF]
PLoS ONE, 2014 INTRODUCTION: Differentiated paediatric epithelial cells can be used to study the role of epithelial cells in asthma. Nasal epithelial cells are easier to obtain and may act as a surrogate for bronchial epithelium in asthma studies.
Surendran Thavagnanam +5 more
doaj +1 more source
Epithelial cell–derived secreted and transmembrane 1a signals to activated neutrophils during pneumococcal pneumonia [PDF]
, 2016 Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells during lung infection.
Belkina, Anna C. +12 more
core +1 more source
Release of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction. [PDF]
PLoS Pathogens, 2017 Oropharyngeal mucosal epithelia of fetuses/neonates/infants and the genital epithelia of adults play a critical role in HIV-1 mother-to-child transmission and sexual transmission of virus, respectively.
Aizezi Yasen +4 more
doaj +1 more source
Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer [PDF]
, 2014 Epithelial cells line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental ...
Agrawal +190 more
core +2 more sources
SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways [PDF]
Nature Medicine, 2020, 2020 The SARS-CoV-2 coronavirus, the etiologic agent responsible for COVID-19 coronavirus disease, is a global threat. To better understand viral tropism, we assessed the RNA expression of the coronavirus receptor, ACE2, as well as the viral S protein priming protease TMPRSS2 thought to govern viral entry in single-cell RNA-sequencing (scRNA-seq) datasets ...
arxiv +1 more source
Intestinal epithelial replacement by transplantation of cultured murine and human cells into the small intestine. [PDF]
, 2019 Adult intestinal epithelial stem cells are a promising resource for treatment of intestinal epithelial disorders that cause intestinal failure and for intestinal tissue engineering.
Cho, Yonghoon +9 more
core +1 more source
Gastroenterology Research and Practice, 2021 Objective. To investigate the histomorphological characteristics and pathological types of hyperproliferation of gastric surface epithelial cells. Methods.
Yangkun Wang +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 The transparent ocular lens in the anterior chamber of the eye is responsible for fine focusing of light onto the retina. The lens is entirely cellular with bulk of the tissue composed of fiber cells, and the anterior hemisphere of the lens is covered by
Justin Parreno +8 more
doaj +1 more source
A genome‐wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells
EMBO Molecular Medicine, 2019 Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic target to ...
Abir Arfaoui +20 more
doaj +1 more source