Artificial intelligence facilitates clinical management of epithelial dysplasia in multiple organs [PDF]
Epithelial dysplasia is a condition characterized by a spectrum of architectural and cytological alterations to the epithelium, resulting from the accumulation of genetic alterations.
Xin-Jia Cai
doaj +1 more source
Introduction: Oral epithelial dysplasia (OED) is associated with high interobserver and intraobserver disagreement. With the exponential increase in the applicability of artificial intelligence tools such as deep learning (DL) in pathology, it would now ...
C Nandini +5 more
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Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. [PDF]
Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and
Butler, Peter C +5 more
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The expression of Cathepsin L in oral lichen planus
Background: Malignant transformation of oral lichen planus (OLP) was reported particularly in erosive type, however, it remains inconclusive. Cathepsin L was shown to promote tumor growth and invasion in many cancers. Therefore, cathepsin L expression in
Athip Kitkhajornkiat +4 more
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Background Ulcerative colitis is a chronic inflammatory disease with apparent extraintestinal manifestations, including in the oral cavity. Oral epithelial dysplasia, an exclusive histopathological diagnosis that is used to predict malignant ...
Kai Sun, Rong-Hui Xia
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Most low-grade oral epithelial dysplasia remains static or regress, but a significant minority of them (4–11%) advances to oral squamous cell carcinoma (OSCC) within a few years.
Madeleine Crawford +3 more
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Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas [PDF]
The bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin. Consequently, preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular ...
Alvaro, D +10 more
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Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions [PDF]
An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from ...
Churin, Yuri +7 more
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Altered β-catenin expression in oral mucosal dysplasia: a comparative study
Objective The current study aimed to investigate the β-catenin expression in oral leukoplakia (OL) with different degrees of epithelial dysplasia and normal oral mucosa.Material and Methods Formalin-fixed, paraffin-embedded tissue samples of 39 OL (mild ...
Brunno Santos de Freitas SILVA +5 more
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Immuno-Histochemical and Quantitative Study of Melanocytes and Melanin Granules in Oral Epithelial Dysplasia [PDF]
Introduction: Oral Epithelial dysplasia (OED) is a potentially malignant disorder that is characterized by the presence of architectural and cytological changes.
Swapna Honwad +3 more
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