Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers
Advanced Science, EarlyView.MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao +7 more
wiley +1 more source
Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel. [PDF]
Front Physiol, 2021 Chen B +5 more
europepmc +1 more source
Advanced Science, EarlyView.Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao +14 more
wiley +1 more source
The small molecule activator S3969 stimulates the epithelial sodium channel by interacting with a specific binding pocket in the channel's β-subunit. [PDF]
J Biol ChemSure F +6 more
europepmc +1 more source
Homocysteine Causes Endothelial Dysfunction via Inflammatory Factor-Mediated Activation of Epithelial Sodium Channel (ENaC). [PDF]
Front Cell Dev Biol, 2021 Liang C +14 more
europepmc +1 more source
A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles
Advanced Science, EarlyView.A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee +6 more
wiley +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct.
AJP - Renal Physiology, 2015 Kelly A. Hyndman +4 more
semanticscholar +1 more source
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
The epithelial sodium channel γ-subunit is processed proteolytically in human kidney.
Journal of the American Society of Nephrology, 2015 Rikke Zachar +7 more
semanticscholar +1 more source