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Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans [PDF]
American Journal of Hypertension, 1998 Hypertensives of African origin have low-renin, sodium-sensitive blood pressure and respond poorly to treatment with angiotensin converting enzyme inhibitors. The epithelial sodium channel may be important in the pathogenesis of essential hypertension in
Patricia B Munroe +2 more
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Epithelial Sodium Channels (ENaCs)
2015Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
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Regulation of renal epithelial sodium channels
Molecular and Cellular Biochemistry, 1992The high selectivity, low conductance, amiloride-blockable, sodium channel of the mammalian distal nephron (i.e. cortical collecting tubule) is the site of discretionary regulation which allows maintainance of total body sodium balance. In order to understand the physiological events that participate in this regulation, we have used the patch-clamp ...
P, Duchatelle +6 more
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The epithelial sodium channel in hypertension
Current Hypertension Reports, 1999Our understanding of Na(+) transport defects has exploded in the past several years, and has provided unique insights into epithelial transport processes, and unusual clinical syndromes resulting from mutations of specific ion transporters. These genetic disorders affect Na(+) balance, with both Na(+) retaining and Na(+) wasting conditions being the ...
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Ammonium interaction with the epithelial sodium channel
American Journal of Physiology-Renal Physiology, 2001The purpose of this study was to investigate the direct effect of NH3/NH[Formula: see text] on mouse epithelial Na+channels (mENaC) expressed in Xenopusoocytes. Two-electrode voltage-clamp and ion-selective microelectrodes were used to measure the Na+current, intracellular pH (pHi), and ion activities in oocytes expressing mENaC.
N L, Nakhoul +3 more
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CFTR Regulation of Epithelial Sodium Channel
2011Cystic fibrosis (CF) is a lethal genetic disorder, characterized by both clinical and genetic complexities, and arises as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The gene encodes a Cl(-) channel belonging to the ABC (ATP Binding Cassette) superfamily of transporters.
Yawar J, Qadri +3 more
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Proceedings of the American Thoracic Society, 2004
Abstract The epithelial sodium channel (ENaC) was cloned just 10 years ago. Since that time, the study of human monogenic diseases (pseudohypoaldosteronism type 1 [PHA-1] and Liddle syndrome), as well as mouse models mimicking salt-losing syndromes (PHA-1) or salt-sensitive hypertension (Liddle syndrome), have greatly contributed to ...
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Abstract The epithelial sodium channel (ENaC) was cloned just 10 years ago. Since that time, the study of human monogenic diseases (pseudohypoaldosteronism type 1 [PHA-1] and Liddle syndrome), as well as mouse models mimicking salt-losing syndromes (PHA-1) or salt-sensitive hypertension (Liddle syndrome), have greatly contributed to ...
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Role of proteolysis in the activation of epithelial sodium channels
Current Opinion in Nephrology & Hypertension, 2007Epithelial sodium channels mediate Na+ transport across high resistance, Na+-transporting epithelia. This review describes recent findings that indicate that epithelial sodium channels are activated by the proteolytic release of inhibitory peptides from the alpha and gamma subunits.Non-cleaved channels have a low intrinsic open probability that may ...
Rebecca P, Hughey +2 more
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1986
Epithelial Na+ channels form an essential component of the Na+ reabsorptive system in a variety of tissues. They permit entry of Na+ into the epithelial cell from the outer fluid compartment, e.g., urine, feces, sweat. Furthermore, they regulate the reabsorptive flow of Na+ across many epithelia and thus are critical to the maintenance of constant salt
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Epithelial Na+ channels form an essential component of the Na+ reabsorptive system in a variety of tissues. They permit entry of Na+ into the epithelial cell from the outer fluid compartment, e.g., urine, feces, sweat. Furthermore, they regulate the reabsorptive flow of Na+ across many epithelia and thus are critical to the maintenance of constant salt
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Urinary proteases degrade epithelial sodium channels
The Journal of Membrane Biology, 1991The mammalian urinary bladder epithelium accommodates volume changes by the insertion and withdrawal of cytoplasmic vesicles. Both apical membrane (which is entirely composed of fused vesicles) and the cytoplasmic vesicles contain three types of ionic conductances, one amiloride sensitive, another a cation-selective conductance and the third a cation ...
S A, Lewis, C, Clausen
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