Results 271 to 280 of about 71,499 (299)

An Alu cassette in the human epithelial sodium channel

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2001
Here, we report the presence of two splice variants of the human epithelial sodium channel alpha subunit (h alpha ENaC) containing Alu cassette, namely h alpha ENaC+22 and h alpha ENaC+Alu, in various tissues. Functional expression of these splice variants with hENaC beta and gamma subunits produced loss-of-channel activity in the Xenopus oocyte ...
Y S, Oh, S, Lee, C, Won, D G, Warnock
openaire   +2 more sources

Intrinsic gating mechanisms of epithelial sodium channels

American Journal of Physiology-Cell Physiology, 2002
The hypothesis that there is a highly conserved, positively charged region distal to the second transmembrane domain in α-ENaC (epithelial sodium channel) that acts as a putative receptor site for the negatively charged COOH-terminal β- and γ-ENaC tails was tested in mutagenesis experiments.
Hong-Long, Ji, Catherine M, Fuller, Dale J, Benos   +2 more
openaire   +2 more sources

Epithelial sodium channels: function, structure, and regulation

Physiological Reviews, 1997
The apical (outward-facing) membranes of high-resistance epithelia contain Na+ channels, traditionally identified by their sensitivity to block by the K(+)-sparing diuretic amiloride. Such channels have been characterized in amphibian skin and urinary bladder, renal collecting duct, distal colon, sweat and salivary glands, lung, and taste buds.
H, Garty, L G, Palmer
openaire   +2 more sources

Epithelial sodium channels and hypertension.

Drug metabolism and disposition: the biological fate of chemicals, 2001
Hypertension is a major risk factor for heart attacks, stroke, and kidney failure. It is estimated to cause as many as 25% of all deaths in the United States, particularly for African Americans, in whom the disease is both more common and more severe.
Y R, Su, A G, Menon
openaire   +1 more source

An aptasensor using ceria electrodeposited-screen-printed carbon electrode for detection of epithelial sodium channel protein as a hypertension biomarker

Royal Society Open Science, 2021
Yeni Wahyuni Hartati, Dina Ratna Komala, Diana Hendrati   +2 more
exaly  

Epithelial sodium channels and hypertension

Journal of Hypertension, 1996
openaire   +2 more sources

The epithelial sodium channel: from molecule to disease

2004
Genetic analysis has demonstrated that Na absorption in the aldosterone-sensitive distal nephron (ASDN) critically determines extracellular blood volume and blood pressure variations. The epithelial sodium channel (ENaC) represents the main transport pathway for Na+ absorption in the ASDN, in particular in the connecting tubule (CNT), which shows the ...
openaire   +3 more sources

Epithelial sodium channels (ENaC)

British Journal of Pharmacology, 2006
S P H Alexander, A Mathie, J A Peters
openaire   +1 more source

Pseudoaldosteronism and the epithelial sodium channel

Current Opinion in Endocrinology & Diabetes, 1999
B. Scott Nunez, Perrin C. White
openaire   +1 more source

The Epithelial Sodium Channel

2007
openaire   +2 more sources