Results 291 to 300 of about 212,176 (344)

Urokinase‐type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)‐mediated sodium retention in experimental nephrotic syndrome

Acta Physiologica, 2019
In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase‐type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC ...
Bernhard N. Bohnert, Sophie Daiminger, Matthias Wörn, Florian Sure, Tobias Staudner, Alexandr V. Ilyaskin, Firas Batbouta, A. Janessa, Jonas C Schneider, Daniel Essigke, S. Kanse, S. Haerteis, C. Korbmacher, F. Artunc   +13 more
semanticscholar   +1 more source

Epithelial Sodium Channels (ENaCs)

2015
Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
openaire   +1 more source

The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis lung disease

Expert opinion on therapeutic targets, 2018
Introduction: Cystic fibrosis is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR anion channel.
P. J. Moore, R. Tarran
semanticscholar   +1 more source

Regulation of renal epithelial sodium channels

Molecular and Cellular Biochemistry, 1992
The high selectivity, low conductance, amiloride-blockable, sodium channel of the mammalian distal nephron (i.e. cortical collecting tubule) is the site of discretionary regulation which allows maintainance of total body sodium balance. In order to understand the physiological events that participate in this regulation, we have used the patch-clamp ...
P, Duchatelle, A, Ohara, B N, Ling, A E, Kemendy, K E, Kokko, P S, Matsumoto, D C, Eaton   +6 more
openaire   +2 more sources

Urinary proteases degrade epithelial sodium channels

The Journal of Membrane Biology, 1991
The mammalian urinary bladder epithelium accommodates volume changes by the insertion and withdrawal of cytoplasmic vesicles. Both apical membrane (which is entirely composed of fused vesicles) and the cytoplasmic vesicles contain three types of ionic conductances, one amiloride sensitive, another a cation-selective conductance and the third a cation ...
S A, Lewis, C, Clausen
openaire   +2 more sources

CFTR Regulation of Epithelial Sodium Channel

2011
Cystic fibrosis (CF) is a lethal genetic disorder, characterized by both clinical and genetic complexities, and arises as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The gene encodes a Cl(-) channel belonging to the ABC (ATP Binding Cassette) superfamily of transporters.
Yawar J, Qadri, Estelle, Cormet-Boyaka, Dale J, Benos, Bakhrom K, Berdiev   +3 more
openaire   +2 more sources

Ammonium interaction with the epithelial sodium channel

American Journal of Physiology-Renal Physiology, 2001
The purpose of this study was to investigate the direct effect of NH3/NH[Formula: see text] on mouse epithelial Na+channels (mENaC) expressed in Xenopusoocytes. Two-electrode voltage-clamp and ion-selective microelectrodes were used to measure the Na+current, intracellular pH (pHi), and ion activities in oocytes expressing mENaC.
N L, Nakhoul, K S, Hering-Smith, S M, Abdulnour-Nakhoul, L L, Hamm   +3 more
openaire   +2 more sources

The epithelial sodium channel in hypertension

Current Hypertension Reports, 1999
Our understanding of Na(+) transport defects has exploded in the past several years, and has provided unique insights into epithelial transport processes, and unusual clinical syndromes resulting from mutations of specific ion transporters. These genetic disorders affect Na(+) balance, with both Na(+) retaining and Na(+) wasting conditions being the ...
openaire   +2 more sources

Intrinsic gating mechanisms of epithelial sodium channels

American Journal of Physiology-Cell Physiology, 2002
The hypothesis that there is a highly conserved, positively charged region distal to the second transmembrane domain in α-ENaC (epithelial sodium channel) that acts as a putative receptor site for the negatively charged COOH-terminal β- and γ-ENaC tails was tested in mutagenesis experiments.
Hong-Long, Ji, Catherine M, Fuller, Dale J, Benos   +2 more
openaire   +2 more sources

Epithelial sodium channels: function, structure, and regulation

Physiological Reviews, 1997
The apical (outward-facing) membranes of high-resistance epithelia contain Na+ channels, traditionally identified by their sensitivity to block by the K(+)-sparing diuretic amiloride. Such channels have been characterized in amphibian skin and urinary bladder, renal collecting duct, distal colon, sweat and salivary glands, lung, and taste buds.
H, Garty, L G, Palmer
openaire   +2 more sources