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Epithelial Sodium Channels (ENaCs)
2015Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
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Activation of the Epithelial Sodium Channel (ENaC) by Serine Proteases
Annual Review of Physiology, 2009The study of human monogenic diseases [pseudohypoaldosteronism type 1 (PHA-1) and Liddle's syndrome] as well as mouse models mimicking the salt-losing syndrome (PHA-1) or salt-sensitive hypertension (Liddle's syndrome) have established the epithelial sodium channel ENaC as a limiting factor in vivo in the control of ionic composition of the ...
Bernard C, Rossier, M Jackson, Stutts
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ClC-5 Chloride Channel Alters Expression of the Epithelial Sodium Channel (ENaC)
Journal of Membrane Biology, 2004ClC-5 chloride channels and epithelial sodium channels (ENaC) are present in many cell types including airway and retinal epithelia. Since ENaC activity is known to be affected by chloride transport, we co-injected Xenopus oocytes with cRNAs encoding ENaC and ClC-5 to investigate whether channel currents are impacted by heterologous co-expression of ...
L, Mo, N K, Wills
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The epithelial sodium channel (ENaC) is intracellularly located as a tetramer
Pfl�gers Archiv European Journal of Physiology, 2002The epithelial sodium channel (ENaC) plays an important role in Na(+) homeostasis by determining the Na(+) transport rate in so-called end-organs such as the renal collecting duct, distal colon, salivary and sweat gland ducts. ENaC is formed by heteromultimerization of three homologous subunits, termed alpha, beta, and gamma ENaC.
Dijkink, L. +3 more
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Hyperuricemia induces hypertension through activation of renal epithelial sodium channel (ENaC)
Metabolism, 2016The mechanisms leading to hypertension associated with hyperuricemia are still unclear. The activity of the distal nephron epithelial sodium channel (ENaC) is an important determinant of sodium balance and blood pressure. Our aim was to investigate whether the effect of hyperuricemia on blood pressure is related to ENaC activation.A hyperuricemic model
Weifeng, Xu +8 more
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Regulation of the epithelial sodium channel (ENaC) by accessory proteins
Current Opinion in Nephrology and Hypertension, 2000The epithelial sodium channel (ENaC) plays a key role in the regulation of fluid absorption in the kidney, lung, colon and exocrine glands, and in the regulation of blood pressure. Abnormal functioning of ENaC is associated with several human diseases, including pseudohypoaldosteronism type I, Liddle's syndrome, pulmonary edema, and cystic fibrosis ...
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Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC)
Bioorganic & Medicinal Chemistry, 2012The epithelial sodium channel (ENaC) is a key factor in the transepithelial movement of sodium, and consequently salt and water homeostasis in various organs. Dysregulated activity of ENaC is associated with human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, cystic fibrosis, pulmonary oedema or intestinal ...
Patrick, Krumm +5 more
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Epithelial sodium channel (ENaC) and the control of blood pressure
Current Opinion in Pharmacology, 2014The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in the maintenance of ...
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Purification of Individual Subunits from the Epithelial Sodium Channel (ENaC)
The FASEB Journal, 2007The Epithelial Sodium Channel (ENaC) is vital in maintaining a homeostatic range of sodium concentration in vertebrates. A disturbance in the normal concentration of sodium inside and outside of the cell can be lethal to the cell and the organism. Studies examining this channel have concluded that at least three homologous but distinct subunits α, β ...
Kacie D'Ann Waiters +2 more
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Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression
Pfl�gers Archiv European Journal of Physiology, 2001In the kidney the epithelial Na+ channel (ENaC) is co-expressed with the sulfonylurea receptor (SUR), an ABC protein that shares a high degree of homology with the cystic fibrosis transmembrane conductance regulator (CFTR) and reportedly modifies ENaC in various preparations.
A A, Konstas +2 more
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