Results 41 to 50 of about 311,587 (357)
Protons sensitize epithelial cells to mesenchymal transition. [PDF]
PLoS ONE, 2012 Proton radiotherapy has gained more favor among oncologists as a treatment option for localized and deep-seated tumors. In addition, protons are a major constituent of the space radiation astronauts receive during space flights.
Minli Wang +5 more
doaj +1 more source
Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]
, 2018 The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M +3 more
core +2 more sources
Clinical significance of epithelial‐mesenchymal transition [PDF]
Clinical and Translational Medicine, 2014 AbstractThe concept of epithelial‐mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research community. Thousands of scientific reports investigated changes in gene, mRNA and protein expression compatible with EMT and their possible ...
Julie Steinestel +3 more
openaire +4 more sources
BMC Cancer, 2018 Background Hepatocellular carcinoma (HCC) is one of the major causes of tumor death; thus, the identification of markers related to its diagnosis and prognosis is critical. Previous studies have revealed that epithelial-to-mesenchymal transition (EMT) is
Yuki Shimoda +20 more
doaj +1 more source
MicroRNAs and epithelial-mesenchymal transition in prostate cancer. [PDF]
, 2016 Prostate cancer (PCa) is a leading cause of male cancer-related deaths. A significant fraction of prostate tumors are very aggressive, often metastasizing to bone, causing significant morbidity and mortality.
Bucay, Nathan +4 more
core +1 more source
Epithelial–Mesenchymal Transition in Ovarian Carcinoma [PDF]
Frontiers in Oncology, 2012 Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is attributed to diagnosis at advanced stage, when the tumor has metastasized, and to chemotherapy resistance, either primary or developing along tumor progression ...
Reuven Reich +2 more
openaire +3 more sources
H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma
Cellular Physiology and Biochemistry, 2018 Background/Aims: Glioma is one of the most devasting tumors and confers dismal prognosis. Long noncoding RNAs(lncRNAs) have emerged as important regulators in various tumors including glioma. A classic lncRNA-H19, which is found to be highly expressed in
Qi Hu +6 more
doaj +1 more source
The DNA methylation inhibitor 5-aza-2’-deoxycytidine retards cell growth and alters gene expression in canine mammary gland tumor cells [PDF]
, 2017 Disruption of gene expression by DNA methylation changes is widely involved in tumorigenesis. Here,to investigate DNA methylation changes in canine, we treated a canine mammary gland tumor cell line with a DNA methylation inhibitor, 5-aza-2 ...
Ito, Tsuyoshi, Kaneda, Masahiro
core +1 more source
The Epithelial-to-Mesenchymal Transition in Cancer [PDF]
Cancers, 2018 The epithelial-to-mesenchymal transition (EMT) occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing.[...]
openaire +3 more sources
New insights into the crossroads between EMT and stemness in the context of cancer [PDF]
, 2016 The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and invasive properties. Stemness is the ability of stem cells to proliferate in
Fabregat Romero, Isabel +2 more
core +1 more source