Results 21 to 30 of about 407,386 (306)
Future of cancer immunotherapy using plant virus-based nanoparticles
Future Science OA, 2019 Immunotherapy potentiates a patient’s immune response against some forms of cancer, including malignant tumors. In this Special Report, we have summarized the use of nanoparticles that have been designed for use in cancer immunotherapy with particular ...
Erum Shoeb, Kathleen Hefferon
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BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes
Nucleic Acids Res., 2017 Antibodies have become an indispensable tool for many biotechnological and clinical applications. They bind their molecular target (antigen) by recognizing a portion of its structure (epitope) in a highly specific manner.
M. C. Jespersen +3 more
semanticscholar +1 more source
Journal of Biomolecular Structure and Dynamics, 2020 At present, novel Coronavirus (2019-nCoV, the causative agent of COVID-19) has caused worldwide social and economic disruption. The disturbing statistics of this infection promoted us to develop an effective vaccine candidate against the COVID-19.
Maryam Enayatkhani +8 more
semanticscholar +1 more source
Understanding the T cell immune response in SARS coronavirus infection
Emerging Microbes and Infections, 2012 The severe acute respiratory syndrome (SARS) epidemic started in late 2002 and swiftly spread across 5 continents with a mortality rate of around 10%.
Hsueh-Ling Janice Oh +3 more
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Recent Progress Towards a Gonococcal Vaccine
Frontiers in Cellular and Infection Microbiology, 2022 Gonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection.
Stavros A. Maurakis +1 more
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An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study
Scientific Reports, 2020 The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical therapy,
Zikun Yang, P. Bogdan, Shahin Nazarian
semanticscholar +1 more source
Nature Biotechnology, 2019 Prediction of HLA epitopes is important for the development of cancer immunotherapies and vaccines. However, current prediction algorithms have limited predictive power, in part because they were not trained on high-quality epitope datasets covering a ...
Siranush Sarkizova +24 more
semanticscholar +1 more source
Annual Review of Immunology, 2020 Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes.
Bjoern Peters, M. Nielsen, A. Sette
semanticscholar +1 more source
Computational Design of a Novel VLP-Based Vaccine for Hepatitis B Virus
Frontiers in Immunology, 2020 Hepatitis B virus (HBV) is a global virus responsible for a universal disease burden for millions of people. Various vaccination strategies have been developed using viral vector, nucleic acid, protein, peptide, and virus-like particles (VLPs) to ...
Saeed Mobini +4 more
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Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
Frontiers in Immunology, 2021 In 2016 Delong et al. discovered a new type of neoepitope formed by the fusion of two unrelated peptide fragments. Remarkably these neoepitopes, called hybrid insulin peptides, or HIPs, are recognized by pathogenic CD4+ T cells in the NOD mouse and human
Stuart I. Mannering +5 more
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