Results 31 to 40 of about 407,386 (306)

Quantifiable predictive features define epitope specific T cell receptor repertoires

Nature, 2017
T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of pathogen-associated epitopes through interactions with peptide and major histocompatibility complexes (pMHCs).
P. Dash, A. Fiore-Gartland, Tomer Hertz, Tomer Hertz, G. Wang, Shalini Sharma, A. Souquette, J. Crawford, E. B. Clemens, Thi H. O. Nguyen, K. Kedzierska, N. Gruta, N. Gruta, Philip Bradley, Philip Bradley, P. Thomas   +15 more
semanticscholar   +1 more source

Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection

Frontiers in Immunology, 2020
Japanese encephalitis virus (JEV) exposure or vaccination could elicit cross-reactive CD8 T cell immunity against heterologous flaviviruses in humans.
Marion Tarbe, Marion Tarbe, Wei Dong, Guang Hu, Guang Hu, Yongfen Xu, Yongfen Xu, Jing Sun, Solene Grayo, Solene Grayo, Xianyang Chen, Chengfeng Qin, Jincun Zhao, Li Liu, Li Liu, Xiuzhen Li, Xiuzhen Li, Qibin Leng, Qibin Leng, Qibin Leng   +19 more
doaj   +1 more source

Epitope spreading

Current Opinion in Immunology, 1996
Epitope (determinant) spreading is the development of immune responses to endogenous epitopes secondary to the release of self antigens during a chronic autoimmune or inflammatory response. The past year has seen considerable advances in our understanding of the contribution of epitope spreading to the chronic pathogenesis of experimental T-cell ...
Vanderlugt, Carol J, Miller, Stephen D
openaire   +2 more sources

Fundamentals and Methods for T- and B-Cell Epitope Prediction

Journal of Immunological Research, 2017
Adaptive immunity is mediated by T- and B-cells, which are immune cells capable of developing pathogen-specific memory that confers immunological protection.
J. L. Sánchez-Trincado, Marta Gomez-Perosanz, P. Reche   +2 more
semanticscholar   +1 more source

Analisis Epitope Sel T pada SARS-Cov2 dengan Pendekatan Bioinformatika

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2020
Pada awal tahun 2020 dunia digemparkan dengan tersebarnya wabah secara global yang menyerang pernapasan seperti wabah SARS pada tahun 2003, yaitu COVID-19. Virus penyebab wabah yang bernama SARS-Cov2 ini ternyata memiliki kemiripan ~87.5% dengan SARS-Cov.
Miftahurrahma Rosyda, Faisal Fajri Rahani   +1 more
doaj   +1 more source

Functional epitopes and neutralizing antibodies of vaccinia virus

Frontiers in Microbiology, 2023
Smallpox is an infectious disease caused by the variola virus, and it has a high mortality rate. Historically it has broken out in many countries and it was a great threat to human health.
Fenghao Peng, Naijing Hu, Yingjun Liu, Cong Xing, Longlong Luo, Xinying Li, Jing Wang, Guojiang Chen, He Xiao, Chenghua Liu, Beifen Shen, Jiannan Feng, Chunxia Qiao   +12 more
doaj   +1 more source

The amino acids differences in epitopes may promote the different allergenicity of ovomucoid derived from hen eggs and quail eggs

Food Science and Human Wellness, 2023
Quail egg ovomucoid can inhibit activation of basophils and eosinophils, while hen egg ovomucoid has been shown to be a major allergen, named Gal d 1. At present, the differences in structure and function between two ovomucoid are unclear.
Mengzhen Hao, Shuai Yang, Shiwen Han, Huilian Che   +3 more
doaj   +1 more source

Current challenges for unseen-epitope TCR interaction prediction and a new perspective derived from image classification

Briefings Bioinform., 2020
The prediction of epitope recognition by T-cell receptors (TCRs) has seen many advancements in recent years, with several methods now available that can predict recognition for a specific set of epitopes.
Pieter Moris, Joey De Pauw, A. Postovskaya, Sofie Gielis, Nicolas De Neuter, Wout Bittremieux, B. Ogunjimi, K. Laukens, P. Meysman   +8 more
semanticscholar   +1 more source

Identification and profiling of HLA-A*02:01-restricted Toxoplasma gondii peptides through immunopeptidomics in HLA-A2.1 transgenic mice

Virulence
HLA class I presentation of pathogen-derived peptides is essential for CD8+ T-cell recognition of Toxoplasma gondii. While in vitro MHC ligands have been documented, the in vivo ligandome during infection progression remains poorly characterized.
Ruiying Liang, Xinru Luo, Weixiang Xia, Haotian Gu, Dan Li, Yongyu Gao, Zonghui Zuo, Fengshan Gao, Jiabo Ding, Xinming Tang, Zibin Li   +10 more
doaj   +1 more source

Advances in the Characterization of the T-Cell Response to Human Herpesvirus-6

Frontiers in Immunology, 2018
Human herpesvirus (HHV) 6 is thought to remain clinically latent in most individuals after primary infection and to reactivate to cause disease in persons with severe immunosuppression.
Derek J. Hanson, Derek J. Hanson, Joshua A. Hill, Joshua A. Hill, David M. Koelle, David M. Koelle, David M. Koelle, David M. Koelle, David M. Koelle   +8 more
doaj   +1 more source