Results 41 to 50 of about 407,386 (306)
Thermal and Acidic Treatments of Gluten Epitopes Affect Their Recognition by HLA-DQ2 in silico
Frontiers in Nutrition, 2021 Celiac disease (CD) is a prevalent disorder with autoimmune features. Dietary exposure of wheat gluten (including gliadins and glutenins) to the small intestine activates the gluten-reactive CD4+ T cells and controls the disease development.
Jihui Gao +13 more
doaj +1 more source
Frontiers in Immunology, 2020 Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can ...
Anne Searls De Groot +17 more
semanticscholar +1 more source
Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection
Frontiers in Immunology, 2018 Zika virus (ZIKV) has recently caused explosive outbreaks in Pacific islands, South- and Central America. Like with other flaviviruses, protective immunity is strongly dependent on potently neutralizing antibodies (Abs) directed against the viral ...
Maximilian Koblischke +8 more
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BioDrugs, 2007 Antibodies are an effective line of defense in preventing infectious diseases. Highly potent neutralizing antibodies can intercept a virus before it attaches to its target cell and, thus, inactivate it. This ability is based on the antibodies' specific recognition of epitopes, the sites of the antigen to which antibodies bind.
Gershoni, Jonathan M. +4 more
openaire +2 more sources
The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus
Vaccines, 2022 After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies ...
Jazmín García-Machorro +3 more
doaj +1 more source
IEDB-AR: immune epitope database—analysis resource in 2019
Nucleic Acids Res., 2019 The Immune Epitope Database Analysis Resource (IEDB-AR, http://tools.iedb.org/) is a companion website to the IEDB that provides computational tools focused on the prediction and analysis of B and T cell epitopes.
Sandeep Kumar Dhanda +12 more
semanticscholar +1 more source
Foods, 2022 Milk protein hydrolysates are common in infant formula, but some of them retain allergenicity due to incomplete hydrolysis of the epitopes for milk allergens.
Di Liu +3 more
doaj +1 more source
VirulenceOrf virus (ORFV) is an acute contact, epitheliotropic, zoonotic, and double-stranded DNA virus that causes significant economic losses in the livestock industry.
Feng Pang, Qinqin Long, Shaobo Liang
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CD4+ T cells targeting dominant and cryptic epitopes from Bacillus anthracis Lethal Factor
Frontiers in Microbiology, 2016 Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the secretion of binary exotoxins.
Stephanie eAscough +11 more
doaj +1 more source
Viruses, 2022 Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity.
Hangjie Zhang +23 more
doaj +1 more source