Results 131 to 140 of about 554,474 (398)
Enterovirus A71 Proteins: Structure and Function
Frontiers in Microbiology, 2018 Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and young children.
Jingjing Yuan +7 more
doaj +1 more source
TepiTool: A Pipeline for Computational Prediction of T Cell Epitope Candidates
Current Protocols in Immunology, 2016 Computational prediction of T cell epitope candidates is currently being used in several applications including vaccine discovery studies, development of diagnostics, and removal of unwanted immune responses against protein therapeutics.
S. Paul +3 more
semanticscholar +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Enhancing Human Immunodeficiency Virus-specific CD8+ T cell Responses with Heteroclitic Peptides
Frontiers in Immunology, 2015 Human immunodeficiency virus (HIV)-specific CD8+ T cells play a critical role in containing HIV replication and delaying disease progression. However, HIV-specific CD8+ T cells become progressively more exhausted as chronic HIV infection proceeds ...
Adeolu eAdegoke, Michael David Grant
doaj +1 more source
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Science, 2009 Influenza virus presents an important and persistent threat to public health worldwide, and current vaccines provide immunity to viral isolates similar to the vaccine strain.
D. Ekiert +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Predicted binding affinity of candidate HDV epitope: a bioinformatics study
Annals of Hepatology, 2007 Hepatitis D virus (HDV) is an RNA virus that can cause hepatitis. Development and approval of new vaccines are the hope for control of the possible emerging pandemic of this infection.
Viroj Wiwanitkit
doaj
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Heterologous protein secretion in Lactococcus lactis: a novel antigen delivery system
Brazilian Journal of Medical and Biological Research, 1999 Lactic acid bacteria (LAB) are Gram-positive bacteria and are generally regarded as safe (GRAS) organisms. Therefore, LAB could be used for heterologous protein secretion and they are good potential candidates as antigen delivery vehicles.
Langella P., Le Loir Y.
doaj
Allergology International, 1999 Food allergy, triggered by an aberrant immune response elicited by orally ingested food allergens, is generated through a complicated mechanism because the allergen interacts with the mucosal immune system (the gut- associated lymphoid tissue, GALT) and ...
Shuichi Kaminogawa +3 more
doaj +1 more source