Results 11 to 20 of about 470,180 (352)

Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients

Emerging Microbes and Infections, 2021
Given the on-going SARS-CoV-2 pandemic, identification of immunogenic targets against the viral protein will provide crucial advances towards the development of sensitive diagnostic tools and vaccination strategies. Our previous study has found that ORF8
Xiaohui Wang, Joy-Yan Lam, Linlei Chen, Shannon Wing-Ngor Au, Kelvin K. W. To, Kwok-Yung Yuen, Kin-Hang Kok   +6 more
doaj   +1 more source

Antibodies validated for routinely processed tissues stain frozen sections unpredictably

BioTechniques, 2021
Background: Antibody validation for tissue staining is required for reproducibility; criteria to ensure validity have been published recently. The majority of these recommendations imply the use of routinely processed (formalin-fixed, paraffin-embedded ...
Maddalena M Bolognesi, Francesco Mascadri, Laura Furia, Mario Faretta, Francesca M Bosisio, Giorgio Cattoretti   +5 more
doaj   +1 more source

BepiPred‐3.0: Improved B‐cell epitope prediction using protein language models

bioRxiv, 2022
B-cell epitope prediction tools are of great medical and commercial interest due to their practical applications in vaccine development. The introduction of protein language models (LM) trained on unprecedented large datasets of protein sequences and ...
Joakim Clifford, M. H. Høie, Morten Nielsen, S. Deleuran, B. Peters, P. Marcatili   +5 more
semanticscholar   +1 more source

Development of a Universal Epitope-Based Influenza Vaccine and Evaluation of Its Effectiveness in Mice

Vaccines, 2022
Vaccination is an effective and economically viable means of protection against the influenza virus, but due to rapid viral evolution, modern seasonal vaccines are not effective enough.
Ramil R. Mintaev, Dina V. Glazkova, Olga V. Orlova, Elena V. Bogoslovskaya, German A. Shipulin   +4 more
doaj   +1 more source

Epitope-Based Specific Antibody Modification [PDF]

, 2023
Modified antibodies play essential roles in various fields, such as analysis, diagnosis, and therapy, which require modified antibodies with optimal physical and biological properties.
Saki, Horie, Kenji, Mishiro, Mio, Nishino, Inori, Domae, Mitsuo, Wakasugi, Tsukasa, Matsunaga, Munetaka, Kunishima   +6 more
core   +1 more source

Revealing Novel-Strain-Specific and Shared Epitopes of Infectious Bronchitis Virus Spike Glycoprotein Using Chemical Linkage of Peptides onto Scaffolds Precision Epitope Mapping

Viruses, 2023
The avian coronavirus, infectious bronchitis virus (IBV), is an economically important infectious disease affecting chickens, with a diverse range of serotypes found globally.
Samantha Sives, Sarah Keep, Erica Bickerton, Lonneke Vervelde   +3 more
doaj   +1 more source

Pediatric Kidney Transplantation—Can We Do Better? The Promise and Limitations of Epitope/Eplet Matching

Frontiers in Pediatrics, 2022
Kidney transplant is the optimal treatment for end-stage kidney disease as it offers significant survival and quality of life advantages over dialysis.
Olga Charnaya, Daniella Levy Erez, Daniella Levy Erez, Sandra Amaral, Dimitrios S. Monos   +4 more
doaj   +1 more source

Deep learning predictions of TCR-epitope interactions reveal epitope-specific chains in dual alpha T cells

bioRxiv, 2023
T cells have the ability to eliminate infected and cancer cells and play an essential role in cancer immunotherapy. T-cell activation is elicited by the binding of the T-cell receptor (TCR) to epitopes displayed on MHC molecules, and the TCR specificity ...
Giancarlo Croce, S. Bobisse, D. Moreno, J. Schmidt, Philippe Guillame, A. Harari, D. Gfeller   +6 more
semanticscholar   +1 more source

Combining different bacteria in vaccine formulations enhances the chance for antiviral cross-reactive immunity: a detailed in silico analysis for influenza A virus

Frontiers in Immunology, 2023
Bacteria are well known to provide heterologous immunity against viral infections through various mechanisms including the induction of innate trained immunity and adaptive cross-reactive immunity.
Andrés Bodas-Pinedo, Esther M. Lafuente, Hector F. Pelaez-Prestel, Alvaro Ras-Carmona, Jose L. Subiza, Pedro A. Reche   +5 more
doaj   +1 more source

Epitope mapping of ORF3a Protein SARS-CoV-2 in Indonesia through computational study

Journal of Tropical Life Science, 2022
In Indonesia, the vaccine for SARS-CoV-2 is still being developed. ORF3a protein of SARS-CoV-2 could be a potential peptide to be used in the vaccine, therapeutic antibodies, and diagnostic kit development. We used the computational approach in designing
Hartiyowidi Yuliawuri, Jeanne Elvia Christian   +1 more
doaj   +1 more source