Results 41 to 50 of about 470,180 (352)

Recent Progress Towards a Gonococcal Vaccine

Frontiers in Cellular and Infection Microbiology, 2022
Gonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection.
Stavros A. Maurakis, Cynthia Nau Cornelissen   +1 more
doaj   +1 more source

A large peptidome dataset improves HLA class I epitope prediction across most of the human population

Nature Biotechnology, 2019
Prediction of HLA epitopes is important for the development of cancer immunotherapies and vaccines. However, current prediction algorithms have limited predictive power, in part because they were not trained on high-quality epitope datasets covering a ...
Siranush Sarkizova, Susan Klaeger, Phuong M. Le, Letitia W. Li, G. Oliveira, Hasmik Keshishian, Christina R. Hartigan, Wandi Zhang, D. Braun, K. Ligon, Pavan Bachireddy, I. Zervantonakis, Jennifer M. Rosenbluth, Tamara Ouspenskaia, T. Law, Sune Justesen, Jonathan D. Stevens, W. Lane, T. Eisenhaure, Guang Lan Zhang, K. Clauser, N. Hacohen, S. Carr, Catherine J. Wu, D. Keskin   +24 more
semanticscholar   +1 more source

Computational Design of a Novel VLP-Based Vaccine for Hepatitis B Virus

Frontiers in Immunology, 2020
Hepatitis B virus (HBV) is a global virus responsible for a universal disease burden for millions of people. Various vaccination strategies have been developed using viral vector, nucleic acid, protein, peptide, and virus-like particles (VLPs) to ...
Saeed Mobini, Milad Chizari, Ladan Mafakher, Elmira Rismani, Elham Rismani   +4 more
doaj   +1 more source

Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes

Frontiers in Immunology, 2021
In 2016 Delong et al. discovered a new type of neoepitope formed by the fusion of two unrelated peptide fragments. Remarkably these neoepitopes, called hybrid insulin peptides, or HIPs, are recognized by pathogenic CD4+ T cells in the NOD mouse and human
Stuart I. Mannering, Stuart I. Mannering, Alan F. Rubin, Alan F. Rubin, Ruike Wang, Pushpak Bhattacharjee   +5 more
doaj   +1 more source

trypanosomatics/The-Chagas-Disease-Antigen-and-Epitope-Atlas: v1.0.0

, 2023
A Trypanosoma cruzi Antigen and Epitope Atlas: deep characterization of individual antibody specificities in human Chagas Disease patients across the ...
Alejandro, Leonel E. Bracco, Fernán Agüero   +2 more
core   +1 more source

Quantifiable predictive features define epitope specific T cell receptor repertoires

Nature, 2017
T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of pathogen-associated epitopes through interactions with peptide and major histocompatibility complexes (pMHCs).
P. Dash, A. Fiore-Gartland, Tomer Hertz, Tomer Hertz, G. Wang, Shalini Sharma, A. Souquette, J. Crawford, E. B. Clemens, Thi H. O. Nguyen, K. Kedzierska, N. Gruta, N. Gruta, Philip Bradley, Philip Bradley, P. Thomas   +15 more
semanticscholar   +1 more source

T Cell Epitope Predictions

Annual Review of Immunology, 2020
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes.
Bjoern Peters, M. Nielsen, A. Sette
semanticscholar   +1 more source

Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection

Frontiers in Immunology, 2020
Japanese encephalitis virus (JEV) exposure or vaccination could elicit cross-reactive CD8 T cell immunity against heterologous flaviviruses in humans.
Marion Tarbe, Marion Tarbe, Wei Dong, Guang Hu, Guang Hu, Yongfen Xu, Yongfen Xu, Jing Sun, Solene Grayo, Solene Grayo, Xianyang Chen, Chengfeng Qin, Jincun Zhao, Li Liu, Li Liu, Xiuzhen Li, Xiuzhen Li, Qibin Leng, Qibin Leng, Qibin Leng   +19 more
doaj   +1 more source

The thermodynamic interactions of three proposed multi-epitope-based vaccines against P. aeruginosa with TLR1, 2, and 4.

, 2023
The thermodynamic interactions of three proposed multi-epitope-based vaccines against P. aeruginosa with TLR1, 2, and 4.
Behnoush Khasheii (16748697), Mahdi Torkamaneh (16748694), Narjes Noori Goodarzi (13531555), Fatemeh Haririzadeh Jouriani (16748691), Farzad Badmasti (9327920), Sepideh Fereshteh (13531558)   +5 more
core   +1 more source

Fundamentals and Methods for T- and B-Cell Epitope Prediction

Journal of Immunological Research, 2017
Adaptive immunity is mediated by T- and B-cells, which are immune cells capable of developing pathogen-specific memory that confers immunological protection.
J. L. Sánchez-Trincado, Marta Gomez-Perosanz, P. Reche   +2 more
semanticscholar   +1 more source