Results 31 to 40 of about 326,590 (304)

Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes

Frontiers in Immunology, 2021
In 2016 Delong et al. discovered a new type of neoepitope formed by the fusion of two unrelated peptide fragments. Remarkably these neoepitopes, called hybrid insulin peptides, or HIPs, are recognized by pathogenic CD4+ T cells in the NOD mouse and human
Stuart I. Mannering, Stuart I. Mannering, Alan F. Rubin, Alan F. Rubin, Ruike Wang, Pushpak Bhattacharjee   +5 more
doaj   +1 more source

Schematic representation of the selection and validation of new putative immunogenic targets and multi-epitope-based vaccines against P. aeruginosa strain 24Pae112 using reverse vaccinology approaches and bioinformatics tools.

, 2023
All criteria and thresholds are shown in the flowchart. OMPs, outer membrane proteins; MEVs, multi-epitope vaccines.
Behnoush Khasheii (16748697), Mahdi Torkamaneh (16748694), Narjes Noori Goodarzi (13531555), Fatemeh Haririzadeh Jouriani (16748691), Farzad Badmasti (9327920), Sepideh Fereshteh (13531558)   +5 more
core   +1 more source

Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection

Frontiers in Immunology, 2020
Japanese encephalitis virus (JEV) exposure or vaccination could elicit cross-reactive CD8 T cell immunity against heterologous flaviviruses in humans.
Marion Tarbe, Marion Tarbe, Wei Dong, Guang Hu, Guang Hu, Yongfen Xu, Yongfen Xu, Jing Sun, Solene Grayo, Solene Grayo, Xianyang Chen, Chengfeng Qin, Jincun Zhao, Li Liu, Li Liu, Xiuzhen Li, Xiuzhen Li, Qibin Leng, Qibin Leng, Qibin Leng   +19 more
doaj   +1 more source

Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites [PDF]

, 2021
The current Malaria RTS,S vaccine is based on virus-like particles (VLPs) comprising the NANP repetitive epitopes from the cicumsporozoite protein (CSP) of Plasmodium falciparum.
Healer, J, Evert, BJ, McConville, R, Steel, RWJ, Healer, Julie, Rehm, BHA, Chen, S, McConville, Robyn, Boddey, Justin A, Huntimer, L, Chen, Shuxiong, Evert, Benjamin J, Boddey, JA, Rehm, Bernd HA, Huntimer, Lucas, Steel, Ryan WJ, Bernd H. A. Rehm, Ryan W. J. Steel, Justin A. Boddey, Lucas Huntimer, Benjamin J. Evert, Shuxiong Chen, Julie Healer, Robyn McConville   +23 more
core   +1 more source

Analisis Epitope Sel T pada SARS-Cov2 dengan Pendekatan Bioinformatika

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2020
Pada awal tahun 2020 dunia digemparkan dengan tersebarnya wabah secara global yang menyerang pernapasan seperti wabah SARS pada tahun 2003, yaitu COVID-19. Virus penyebab wabah yang bernama SARS-Cov2 ini ternyata memiliki kemiripan ~87.5% dengan SARS-Cov.
Miftahurrahma Rosyda, Faisal Fajri Rahani   +1 more
doaj   +1 more source

Functional epitopes and neutralizing antibodies of vaccinia virus

Frontiers in Microbiology, 2023
Smallpox is an infectious disease caused by the variola virus, and it has a high mortality rate. Historically it has broken out in many countries and it was a great threat to human health.
Fenghao Peng, Naijing Hu, Yingjun Liu, Cong Xing, Longlong Luo, Xinying Li, Jing Wang, Guojiang Chen, He Xiao, Chenghua Liu, Beifen Shen, Jiannan Feng, Chunxia Qiao   +12 more
doaj   +1 more source

The amino acids differences in epitopes may promote the different allergenicity of ovomucoid derived from hen eggs and quail eggs

Food Science and Human Wellness, 2023
Quail egg ovomucoid can inhibit activation of basophils and eosinophils, while hen egg ovomucoid has been shown to be a major allergen, named Gal d 1. At present, the differences in structure and function between two ovomucoid are unclear.
Mengzhen Hao, Shuai Yang, Shiwen Han, Huilian Che   +3 more
doaj   +1 more source

Review of Immunoinformatic approaches to in-silico B-cell epitope prediction [PDF]

, 2007
In this paper, the current state of in-silico, B-cell epitope prediction is discussed. Recommendations for improving some of the approaches encountered are outlined, along with the presentation of an entirely novel technique, which uses molecular ...
Rick Reitmaier
core   +1 more source

Additional file 1 of Design of a multi-epitope-based peptide vaccine against the S and N proteins of SARS-COV-2 using immunoinformatics approach

, 2022
Additional file 1. Design of a multi-epitope-based peptide vaccine against the S and N proteins of SARS -COV-2 using Immunoinformatics Approach. ( http://galaxy.seoklab.org/cgi-bin/report_REFINE.cgi?key=27ac3cd2f0bd1f0372ce673a67eac9e1 , https://npsa ...
Farnaz Kheirandish (805358), Seyedeh Zeinab Hosseini (12044459), Arian Karimi Rouzbahani (12044456)   +2 more
core   +1 more source

Restoration and HDX-MS Epitope Mapping of a Broad-Spectrum SARS-Cov-2 Antibody [PDF]

, 2023
Highly contagious diseases like SARS-Cov-2 posts a major threat for public health and global economy, both preventative and therapeutic solutions are therefore urgently needed. Through the use of epitope-guided antibody design, we successfully restored a
Jason, Pan, Sara, Zhang, Mike, Young
core   +1 more source