Results 31 to 40 of about 300,540 (308)

Epitope Mapping [PDF]

BioDrugs, 2007
Antibodies are an effective line of defense in preventing infectious diseases. Highly potent neutralizing antibodies can intercept a virus before it attaches to its target cell and, thus, inactivate it. This ability is based on the antibodies' specific recognition of epitopes, the sites of the antigen to which antibodies bind.
Gershoni, Jonathan M., Roitburd-Berman, Anna, Siman-Tov, Dror D., Freund, Natalia Tarnovitski, Weiss, Yael   +4 more
openaire   +2 more sources

Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease

, 2009
Background - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active
Yang, P.Z., Du, L.P., Zhao, C.L., Lin, X.M., He, H., Zhou, H.Y., Kijlstra, A.   +6 more
core   +1 more source

Schematic representation of the selection and validation of new putative immunogenic targets and multi-epitope-based vaccines against P. aeruginosa strain 24Pae112 using reverse vaccinology approaches and bioinformatics tools.

, 2023
All criteria and thresholds are shown in the flowchart. OMPs, outer membrane proteins; MEVs, multi-epitope vaccines.
Behnoush Khasheii (16748697), Mahdi Torkamaneh (16748694), Narjes Noori Goodarzi (13531555), Fatemeh Haririzadeh Jouriani (16748691), Farzad Badmasti (9327920), Sepideh Fereshteh (13531558)   +5 more
core   +1 more source

The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus

Vaccines, 2022
After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies ...
Jazmín García-Machorro, Gema Lizbeth Ramírez-Salinas, Marlet Martinez-Archundia, José Correa-Basurto   +3 more
doaj   +1 more source

A Method for Screening Proteases That Can Specifically Hydrolyze the Epitope AA83-105 of α_s1-Casein Allergen

Foods, 2022
Milk protein hydrolysates are common in infant formula, but some of them retain allergenicity due to incomplete hydrolysis of the epitopes for milk allergens.
Di Liu, Xiaozhe Lv, Yanjun Cong, Linfeng Li   +3 more
doaj   +1 more source

Additional file 1 of Design of a multi-epitope-based peptide vaccine against the S and N proteins of SARS-COV-2 using immunoinformatics approach

, 2022
Additional file 1. Design of a multi-epitope-based peptide vaccine against the S and N proteins of SARS -COV-2 using Immunoinformatics Approach. ( http://galaxy.seoklab.org/cgi-bin/report_REFINE.cgi?key=27ac3cd2f0bd1f0372ce673a67eac9e1 , https://npsa ...
Farnaz Kheirandish (805358), Seyedeh Zeinab Hosseini (12044459), Arian Karimi Rouzbahani (12044456)   +2 more
core   +1 more source

Designing a multi-epitope subunit vaccine against Orf virus using molecular docking and molecular dynamics

Virulence
Orf virus (ORFV) is an acute contact, epitheliotropic, zoonotic, and double-stranded DNA virus that causes significant economic losses in the livestock industry.
Feng Pang, Qinqin Long, Shaobo Liang
doaj   +1 more source

CD4+ T cells targeting dominant and cryptic epitopes from Bacillus anthracis Lethal Factor

Frontiers in Microbiology, 2016
Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the secretion of binary exotoxins.
Stephanie eAscough, Rebecca Jo Ingram, Karen eChu, Julie eMusson, Stephen eMoore, Theresa eGallagher, Leslie eBaillie, Ethel Diane Williamson, John eRobinson, Bernard eMaillere, Rosemary eBoyton, Daniel eAltmann   +11 more
doaj   +1 more source

The CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets

Viruses, 2022
Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity.
Hangjie Zhang, Wenling Xiao, Min Zhao, Yingze Zhao, Yongli Zhang, Dan Lu, Shuangshuang Lu, Qingxu Zhang, Weiyu Peng, Liumei Shu, Jie Zhang, Sai Liu, Kexin Zong, Pengyan Wang, Beiwei Ye, Shihua Li, Shuguang Tan, Fuping Zhang, Jianfang Zhou, Peipei Liu, Guizhen Wu, Xuancheng Lu, George F. Gao, William J. Liu   +23 more
doaj   +1 more source

Epitope-specific antibody responses in gD2 immunized guinea pigs and humans.

, 2018
Epitope-specific antibody responses in gD2 immunized guinea pigs and humans.
Harvey M. Friedman (3682018), Lauren M. Hook (3682027), Tina M. Cairns (4110190), Sita Awasthi (3682030), Gary H. Cohen (203335), Roselyn J. Eisenberg (203337), Benjamin D. Brooks (714084), Noah T. Ditto (4110187)   +7 more
core   +1 more source