Results 51 to 60 of about 326,590 (304)

Designing a multi-epitope subunit vaccine against Orf virus using molecular docking and molecular dynamics

Virulence
Orf virus (ORFV) is an acute contact, epitheliotropic, zoonotic, and double-stranded DNA virus that causes significant economic losses in the livestock industry.
Feng Pang, Qinqin Long, Shaobo Liang
doaj   +1 more source

CD4+ T cells targeting dominant and cryptic epitopes from Bacillus anthracis Lethal Factor

Frontiers in Microbiology, 2016
Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the secretion of binary exotoxins.
Stephanie eAscough, Rebecca Jo Ingram, Karen eChu, Julie eMusson, Stephen eMoore, Theresa eGallagher, Leslie eBaillie, Ethel Diane Williamson, John eRobinson, Bernard eMaillere, Rosemary eBoyton, Daniel eAltmann   +11 more
doaj   +1 more source

The CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets

Viruses, 2022
Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity.
Hangjie Zhang, Wenling Xiao, Min Zhao, Yingze Zhao, Yongli Zhang, Dan Lu, Shuangshuang Lu, Qingxu Zhang, Weiyu Peng, Liumei Shu, Jie Zhang, Sai Liu, Kexin Zong, Pengyan Wang, Beiwei Ye, Shihua Li, Shuguang Tan, Fuping Zhang, Jianfang Zhou, Peipei Liu, Guizhen Wu, Xuancheng Lu, George F. Gao, William J. Liu   +23 more
doaj   +1 more source

Neutralizing Antibody Response to Hepatitis C Virus

Viruses, 2011
A critical first step in a “rational vaccine design” approach for hepatitis C virus (HCV) is to identify the most relevant mechanisms of immune protection. Emerging evidence provides support for a protective role of virus neutralizing antibodies, and the
Zhen-Yong Keck, Yong Wang, Steven K. H. Foung   +2 more
doaj   +1 more source

In Silico Prediction of Cross-Reactive Epitopes of Tropomyosin from Shrimp and Other Arthropods Involved in Allergy

Molecules, 2022
Tropomyosin in shellfish is considered a major cross-reactive allergen in house dust mites and cockroaches; however, the specific epitopes have not been elucidated. Therefore, this study aimed to identify the consensus antigenic determinant among shrimp,
Jirakrit Saetang, Varomyalin Tipmanee, Soottawat Benjakul   +2 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

GII.4 Human Norovirus: Surveying the Antigenic Landscape

Viruses, 2019
Human norovirus is the leading cause of viral acute onset gastroenteritis disease burden, with 685 million infections reported annually. Vulnerable populations, such as children under the age of 5 years, the immunocompromised, and the elderly show a need
Michael L. Mallory, Lisa C. Lindesmith, Rachel L. Graham, Ralph S. Baric   +3 more
doaj   +1 more source

Non-Toxin-Based Clostridioides difficile Vaccination Approaches

Pathogens, 2023
Clostridioides difficile (CD) is a Gram-positive, anaerobic bacterium that infects mainly hospitalized and elderly people who have been treated with long-term antibiotic therapy leading to dysbiosis.
Agnieszka Razim, Sabina Górska, Andrzej Gamian   +2 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Identification of the Binding Epitope of an Anti-Mouse CCR6 Monoclonal Antibody (C₆Mab-13) Using 1× Alanine Scanning

Antibodies, 2023
CC chemokine receptor 6 (CCR6) is one of the members of the G-protein-coupled receptor (GPCR) family that is upregulated in many immune-related cells, such as B lymphocytes, effector and memory T cells, regulatory T cells, and immature dendritic cells ...
Tomohiro Tanaka, Mayuki Tawara, Hiroyuki Suzuki, Mika K. Kaneko, Yukinari Kato   +4 more
doaj   +1 more source