Results 71 to 80 of about 470,180 (352)

Restoration and HDX-MS Epitope Mapping of a Broad-Spectrum SARS-Cov-2 Antibody [PDF]

, 2023
Highly contagious diseases like SARS-Cov-2 posts a major threat for public health and global economy, both preventative and therapeutic solutions are therefore urgently needed. Through the use of epitope-guided antibody design, we successfully restored a
Jason, Pan, Sara, Zhang, Mike, Young
core   +1 more source

Designing a multi-epitope subunit vaccine against Orf virus using molecular docking and molecular dynamics

Virulence
Orf virus (ORFV) is an acute contact, epitheliotropic, zoonotic, and double-stranded DNA virus that causes significant economic losses in the livestock industry.
Feng Pang, Qinqin Long, Shaobo Liang
doaj   +1 more source

CD4+ T cells targeting dominant and cryptic epitopes from Bacillus anthracis Lethal Factor

Frontiers in Microbiology, 2016
Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the secretion of binary exotoxins.
Stephanie eAscough, Rebecca Jo Ingram, Karen eChu, Julie eMusson, Stephen eMoore, Theresa eGallagher, Leslie eBaillie, Ethel Diane Williamson, John eRobinson, Bernard eMaillere, Rosemary eBoyton, Daniel eAltmann   +11 more
doaj   +1 more source

The CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets

Viruses, 2022
Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity.
Hangjie Zhang, Wenling Xiao, Min Zhao, Yingze Zhao, Yongli Zhang, Dan Lu, Shuangshuang Lu, Qingxu Zhang, Weiyu Peng, Liumei Shu, Jie Zhang, Sai Liu, Kexin Zong, Pengyan Wang, Beiwei Ye, Shihua Li, Shuguang Tan, Fuping Zhang, Jianfang Zhou, Peipei Liu, Guizhen Wu, Xuancheng Lu, George F. Gao, William J. Liu   +23 more
doaj   +1 more source

Discontinuous Epitope Mapping of Antibodies Using Bacterial Cell Surface Display of Folded Domains

, 2018
Knowledge of the exquisite-binding surface of an antibody on its target protein is of great value, in particular for therapeutic antibodies for understanding method of action and for stratification of patients carrying the necessary epitope for desired ...
Rockberg, Johan,, Anna-Luisa Volk, Johan Rockberg, Volk, Anna-Luisa,   +3 more
core   +1 more source

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

Scientific Reports, 2019
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-Saharan Africa. The elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and
R. A. Shey, S. Ghogomu, K. Esoh, Neba Derrick Nebangwa, C. M. Shintouo, Nkemngo Francis Nongley, B. F. Asa, Ferdinand Njume Ngale, L. Vanhamme, J. Souopgui   +9 more
semanticscholar   +1 more source

Neutralizing Antibody Response to Hepatitis C Virus

Viruses, 2011
A critical first step in a “rational vaccine design” approach for hepatitis C virus (HCV) is to identify the most relevant mechanisms of immune protection. Emerging evidence provides support for a protective role of virus neutralizing antibodies, and the
Zhen-Yong Keck, Yong Wang, Steven K. H. Foung   +2 more
doaj   +1 more source

In Silico Prediction of Cross-Reactive Epitopes of Tropomyosin from Shrimp and Other Arthropods Involved in Allergy

Molecules, 2022
Tropomyosin in shellfish is considered a major cross-reactive allergen in house dust mites and cockroaches; however, the specific epitopes have not been elucidated. Therefore, this study aimed to identify the consensus antigenic determinant among shrimp,
Jirakrit Saetang, Varomyalin Tipmanee, Soottawat Benjakul   +2 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Epitope-specific antibody responses in gD2 immunized guinea pigs and humans.

, 2018
Epitope-specific antibody responses in gD2 immunized guinea pigs and humans.
Harvey M. Friedman (3682018), Lauren M. Hook (3682027), Tina M. Cairns (4110190), Sita Awasthi (3682030), Gary H. Cohen (203335), Roselyn J. Eisenberg (203337), Benjamin D. Brooks (714084), Noah T. Ditto (4110187)   +7 more
core   +1 more source