Results 91 to 100 of about 470,180 (352)

Epitope Mapping of Antibodies Using Bacterial Cell Surface Display of Gene Fragment Libraries

, 2018
The unique property of specific high affinity binding to more or less any target of interest has made antibodies tremendously useful in numerous applications.
Rockberg, Johan,, Anna-Luisa Volk, Johan Rockberg, Volk, Anna-Luisa,, Hu, Francis Jingxin,, Francis Jingxin Hu   +5 more
core   +1 more source

Epitopes in ChEBI - A Collaboration with the IEDB [PDF]

, 2010
*ChEBI background:* Chemical Entities of Biological Interest (ChEBI) is a curated database of small chemical entities important in biosystems. As well as a description of entities, it provides a semantically rich knowledge base; and an internal hierarchy
Marcus Ennis, Randi Vita, Christoph Steinbeck, Zara Josephs, Gareth Owen, Bjoern Peters, Steve Turner   +6 more
core   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Identification of the pentapeptide constituting a dominant epitope common to all eukaryotic heat shock protein 90 molecular chaperones. [PDF]

, 2005
We previously reported that, in human heat shock protein (Hsp) 90 (hHsp90), there are 4 highly immunogenic sites, designated sites Ia, Ib, Ic, and II.
Takayuki K. Nemoto, Fukuma, Yutaka, Nemoto, Takayuki K, Yutaka Fukuma, Mizuno, Akio, Kishimoto, Jun, Jun Kishimoto, Akio Mizuno   +7 more
core   +1 more source

Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites [PDF]

, 2021
The current Malaria RTS,S vaccine is based on virus-like particles (VLPs) comprising the NANP repetitive epitopes from the cicumsporozoite protein (CSP) of Plasmodium falciparum.
Healer, J, Evert, BJ, McConville, R, Steel, RWJ, Healer, Julie, Rehm, BHA, Chen, S, McConville, Robyn, Boddey, Justin A, Huntimer, L, Chen, Shuxiong, Evert, Benjamin J, Boddey, JA, Rehm, Bernd HA, Huntimer, Lucas, Steel, Ryan WJ   +15 more
core   +1 more source

Identification of Two Critical Contact Residues in a Pathogenic Epitope from Tetranectin for Monoclonal Antibody Binding and Preparation of Single-Chain Variable Fragments

Biomolecules
Sepsis is a fetal disease that requires a clear diagnostic biomarker for timely antibiotic treatment. Recent research has identified a pyroptosis-inducing epitope known as P5-5 in tetranectin (TN), a plasma protein produced by monocytes.
Juncheng Wang, Meng Liu, Rukhshan Zahid, Wenjie Zhang, Zecheng Cai, Yan Liang, Die Li, Jiasheng Hao, Yuekang Xu   +8 more
doaj   +1 more source

Immunoinformatic analysis of glycoprotein from bovine ephemeral fever virus

Biomedical and Biotechnology Research Journal, 2018
Background: Bovine ephemeral fever virus (BEFV) is an arthropod-borne virus that is highly infective for cattle and water buffalo. The infection has important economic losses and is common in tropical and subtropical regions.
Mehran Bakhshesh, Mohammad Mehdi Ranjbar, Shokoofeh Almasi   +2 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

CD8 epitope escape and reversion in acute HCV infection. [PDF]

, 2004
In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T lymphocyte (CTL) responses are associated with initial control of viremia.
Paul Klenerman, Reyor, LL, Sheridan, I., Julian Schulze zur Wiesch, Walker, B.D., Joerg Timm, Laura L. Reyor, Gandhi, R. T., Allen, T.M., Lauer, GM, Isabelle Sheridan, Arthur Y. Kim, Todd M. Allen, Nina Bhardwaj, Klenerman, P., Thillagavathie Pillay, Timm, J, Allen, TM, Chung, R.T., Bruce D. Walker, Lucas, M., Ouchi, K, Gandhi, RT, Georg M. Lauer, Michaela Lucas, Lauer, G.M., Kim, A.Y., Daniel G. Kavanagh, Raymond T. Chung, Schulze zur Wiesch, J, Lucas, M, Bhardwaj, N., Klenerman, Paul, Kei Ouchi, Pillay, T, Reyor, L.L., Klenerman, P, Walker, BD, Rajesh T. Gandhi, Bhardwaj, N, Kavanagh, D.G., Kavanagh, DG, Timm, J., zur Wiesch, J.S., Chung, RT, Kim, AY, Ouchi, K., Sheridan, I, Pillay, T.   +48 more
core   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source