Results 21 to 30 of about 470,180 (352)

A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV

Science, 2020
Targeting the SARS-CoV-2 spike The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors.
M. Yuan, N. Wu, Xueyong Zhu, C. D. Lee, R. So, Huibin Lv, C. Mok, I. Wilson   +7 more
semanticscholar   +1 more source

B-Cell Epitope Discovery: The First Protein Flexibility-Based Algorithm – Zika Virus Conserved Epitope Demonstration [PDF]

, 2020
Antibody-antigen interaction – at antigenic local environments called B-cell epitopes – is a prominent mechanism for neutralization of infection. Effective mimicry, and display, of B-cell epitopes is key to vaccine design.
Peter J., Ortoleva, Jason S., Grosch, Daniel W., Biner   +2 more
core   +1 more source

Epitope-Directed Antibody Elicitation by Genetically Encoded Chemical Cross-Linking Reactivity in the Antigen

, 2023
No current methods can selectively elicit an antibody response to a specific conformational epitope in a whole antigen in vivo. Here, we incorporated Nε-acryloyl-l-lysine (AcrK) or Nε-crotonyl-l-lysine (Kcr) with cross-linking activities into the ...
Liang Xu (102656), Weiping Wu (534670), Yinjian Zhou (16028715), Shengwang Dai (7352774), Jay Zhang (422679), Yuhan Zhang (2792089), Shuang Liu (8449), Shuqin Xiang (16028712), Zihan Zhang (3117441), Chaoyang Zhu (2635984), Chengxiang Li (5278343), Hui Guo (110581), Feng Wang (44414), Longxin Chen (380248)   +13 more
core   +2 more sources

Epitope-Based Specific Antibody Modifications

, 2023
Modified antibodies have essential roles in analytic, diagnostic, and therapeutic uses, and thus, these antibodies are required to have optimal physical and biological properties.
Kenji Mishiro (1910746), Munetaka Kunishima (1490335), Mitsuo Wakasugi (9303), Inori Domae (17261852), Saki Horie (17073966), Mio Nishino (17261849), Tsukasa Matsunaga (2706478)   +6 more
core   +1 more source

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

Science, 2020
Profiling coronaviruses Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), result in severe infections.
Ellen Shrock, Eric Fujimura, Tomasz Kula, R. Timms, I-Hsiu Lee, Yumei Leng, M. Robinson, Brandon M. Sie, Mamie Z. Li, Yuezhou Chen, J. Logue, Adam Zuiani, Denise J. McCulloch, Felipe J. N. Lelis, Stephanie N. Henson, Daniel R. Monaco, M. Travers, S. Habibi, W. Clarke, P. Caturegli, O. Laeyendecker, A. Piechocka-Trocha, Jonathan Z. Li, A. Khatri, H. Chu, A. Villani, Kyle R. Kays, M. Goldberg, N. Hacohen, Michael R. Filbin, Xu G. Yu, Bruce D. Walker, D. Wesemann, H. Larman, J. Lederer, S. Elledge   +35 more
semanticscholar   +1 more source

Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting

Cell Reports Medicine, 2021
Summary CD8+ T cell recognition of peptide epitopes plays a central role in immune responses against pathogens and tumors. However, the rules that govern which peptides are truly recognized by existing T cell receptors (TCRs) remain poorly understood ...
J. Schmidt, Angela R. Smith, Morgane Magnin, Julien Racle, J. Devlin, S. Bobisse, J. Cesbron, Victor Bonnet, Santiago J. Carmona, Florian Huber, G. Ciriello, D. Speiser, M. Bassani-Sternberg, G. Coukos, B. Baker, A. Harari, D. Gfeller   +16 more
semanticscholar   +1 more source

Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease [PDF]

, 2009
Background - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active
Yang, P.Z., Du, L.P., Zhao, C.L., Lin, X.M., He, H., Zhou, H.Y., Kijlstra, A.   +6 more
core   +1 more source

The Immune Epitope Database (IEDB): 2018 update

Nucleic Acids Res., 2018
The Immune Epitope Database (IEDB, iedb.org) captures experimental data confined in figures, text and tables of the scientific literature, making it freely available and easily searchable to the public. The scope of the IEDB extends across immune epitope
R. Vita, Swapnil Mahajan, James A. Overton, Sandeep Kumar Dhanda, Sheridan Martini, Jason R. Cantrell, D. Wheeler, A. Sette, Bjoern Peters   +8 more
semanticscholar   +1 more source

A candidate multi-epitope vaccine against SARS-CoV-2

Scientific Reports, 2020
In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively.
Tamalika Kar, Utkarsh Narsaria, Srijita Basak, Debashrito Deb, F. Castiglione, D. Mueller, A. Srivastava   +6 more
semanticscholar   +1 more source

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Nature, 2021
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection1.
Jenna J. Guthmiller, Julianna Han, Henry A. Utset, Lei Li, L. Lan, Carole Henry, Christopher T. Stamper, Meagan McMahon, George O’Dell, M. Fernández-Quintero, Alec W. Freyn, F. Amanat, O. Stovicek, Lauren E. Gentles, Sara T. Richey, Alba Torrents de la Peña, Victoria C. Rosado, H. Dugan, Nai-Ying Zheng, Micah E. Tepora, Dalia J. Bitar, Siriruk Changrob, Shirin Strohmeier, Min Huang, A. García-Sastre, K. Liedl, J. Bloom, R. Nachbagauer, P. Palese, F. Krammer, L. Coughlan, A. Ward, P. Wilson   +32 more
semanticscholar   +1 more source