Results 251 to 260 of about 326,590 (304)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Identification of Conserved B-Cell Epitope Candidates Associated with Neutralizing Activity of Bovine Coronavirus Spike Protein. [PDF]

Animals (Basel)
Ren Y, Yue H, Tang C, Chen X.
europepmc   +1 more source

The Cancer Epitope Database and Analysis Resource (CEDAR): current capabilities and future directions. [PDF]

Front Oncol
Koşaloğlu-Yalçın Z, Carri I, Marrama D, Richardson E, Greenbaum J, Blazseka N, Vita R, Carter H, Nielsen M, Peters B, Sette A.   +10 more
europepmc   +1 more source

Epitope selection overcomes antigen shedding to enable effective CAR-M therapy in solid tumors. [PDF]

Mol Ther Oncol
Liu W, Liu X, Kozlov S, Zhou Q, Onda M, Wagner N, Pastan I.   +6 more
europepmc   +1 more source

Artificial Intelligence-Driven Nanobody Engineering for Pathogen Recognition: From Functional Epitope Prioritization to Multimodal Foundation Models. [PDF]

Biomolecules
Hu RS, Ehsan M, Luo W, Zhou J, Xiao YL, Wang HX, Li CY, Gu K.   +7 more
europepmc   +1 more source

An in silico VAR2CSA-based multi-epitope vaccine candidate (PM-MEV-k1) shows favourable Structural and Immune Simulation parameters for protection against placental malaria

Kwi PN, Shey RA, Tangan YAS, Eniyou CO, Nchanji GT, Chick JA, Ayang BE, Ngomba AE, Moyeh MN, Ghogomu SM, Apinjoh TO, Amambua-Ngwa A.   +11 more
europepmc   +1 more source