Results 241 to 250 of about 300,540 (308)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A Novel Mechanism of STAT3 Activation by Oncogenic Signaling. [PDF]

Cells
Muthu M, Venkatesh J, Reddy KB, Rishi AK.   +3 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In-silico design of a multi-epitope vaccine candidate against Strongyloides stercoralis. [PDF]

BMC Infect Dis
Stong Tangan YA, Nchanji GT, Ndumu E, Ayuk AB, Ngala KB, Dulandzev MB, Yaah NE, Shinyuy LM, Shintouo CM, Yengo BN, Enowkpen AE, Efeti MT, Chick JA, Gwei KY, Lemoge AA, Vanhamme L, Souopgui J, Ghogomu SM, Shey RA.   +18 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Comprehensive longitudinal profiling identifies differential frequency, epitope specificity, and effector function of CD8⁺ T-cells across COVID-19 disease severities. [PDF]

EBioMedicine
Amaya Hernandez SP, Munk KK, Danilov K, Kadivar M, Hersby DS, Tamhane T, Stegenborg-Grathwohl SM, Pedersen AG, Gang AO, Hadrup SR, Saini SK.   +10 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Conserved Linear Epitopes in the VP1 Protein of Foot-and-Mouth Disease Virus Serotype SAT2: Identification and Characterization. [PDF]

Transbound Emerg Dis
Zhu YQ, Shi XT, Burman A, Shi ZW, Xi T, Liao HC, Luo JC, Chen J, Wang L, Xie YG, Yang QQ, Tian H, Zheng HX, King DP.   +13 more
europepmc   +1 more source

Pan-genome and reverse vaccinology for a multi-epitope vaccine against circulating post-2022 Monkeypox virus strains. [PDF]

PLoS One
Saber MA, Shovon MHJ, Imtiaz M, Tauhida SJ, Das S, Tareq MMI, Tripty MIA, Hossain MR, Siam LS, Zilani MNH, Saifullah, Rahman SMK, Khan U, Hasan MN.   +13 more
europepmc   +1 more source