Results 221 to 230 of about 470,180 (352)

Epitop [PDF]

, 2017
H. Renz, B. Gierten
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure.

Immunity, 2018
P. Kwong, J. Mascola
semanticscholar   +1 more source

Designing a Multi-Epitope Vaccine Candidate Against <i>Rhodococcus equi</i> Based on the Bioinformatics Technique. [PDF]

Vet Sci
Gao S, Li G, Wang X, Gu W, Guo D, Xian Z, Ma X, Meng J, Zhao H, Liu L.   +9 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Conformational bias in SARS-CoV-2 Spike CD4+ T-cell epitope dominance. [PDF]

Front Immunol
Landry SJ, Steede NK, Tiomkin Y, Smith H, Mettu RR, Gragert L, Aberle JH, Zwezdaryk KJ, Zheng C, Kolls JK, Gunn BM, Murrell AE, Trinh IV, Schieffelin JS, Robinson JE, Norton EB.   +15 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Reduced T cell epitope cross-conservation and immunogenic potential is associated with emergence of a dominant influenza subclade K in 2025. [PDF]

Hum Vaccin Immunother
Gutierrez AH, Tivin J, Gabriel B, De Groot AS.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

<i>In silico</i> discovery and serological validation of <i>Trypanosoma cruzi</i>-specific B-cell epitopes for high-precision Chagas disease diagnosis. [PDF]

Front Microbiol
Candia-Puma MA, Goyzueta-Mamani LD, Barazorda-Ccahuana HL, Câmara RSB, Pereira IAG, Silva AL, Rodrigues MM, Assis BPN, Chaves AT, Corrêa LAVA, Rocha MODC, Gonçalves DU, Gonçalves AAM, de Moura AB, Galdino AS, Machado-de-Avila RA, Giunchetti RC, Coelho EAF, Chávez-Fumagalli MA.   +18 more
europepmc   +1 more source