Results 61 to 70 of about 300,540 (308)

Identification of Two Critical Contact Residues in a Pathogenic Epitope from Tetranectin for Monoclonal Antibody Binding and Preparation of Single-Chain Variable Fragments

Biomolecules
Sepsis is a fetal disease that requires a clear diagnostic biomarker for timely antibiotic treatment. Recent research has identified a pyroptosis-inducing epitope known as P5-5 in tetranectin (TN), a plasma protein produced by monocytes.
Juncheng Wang, Meng Liu, Rukhshan Zahid, Wenjie Zhang, Zecheng Cai, Yan Liang, Die Li, Jiasheng Hao, Yuekang Xu   +8 more
doaj   +1 more source

Immunoinformatic analysis of glycoprotein from bovine ephemeral fever virus

Biomedical and Biotechnology Research Journal, 2018
Background: Bovine ephemeral fever virus (BEFV) is an arthropod-borne virus that is highly infective for cattle and water buffalo. The infection has important economic losses and is common in tropical and subtropical regions.
Mehran Bakhshesh, Mohammad Mehdi Ranjbar, Shokoofeh Almasi   +2 more
doaj   +1 more source

Defining the epichromatin epitope [PDF]

Nucleus, 2017
Epichromatin is identified by immunostaining fixed and permeabilized cells with particular bivalent anti-nucleosome antibodies (mAbs PL2-6 and 1H6). During interphase, epichromatin resides adjacent to the inner nuclear membrane; during mitosis, at the outer surface of mitotic chromosomes.
Travis J. Gould, Katalin Tóth, Norbert Mücke, Jörg Langowski, Alexandra S. Hakusui, Ada L. Olins, Donald E. Olins   +6 more
openaire   +2 more sources

Proteolytic Fragmentation for Epitope Mapping

, 2009
The use of antigen fragments generated by specific proteolytic cleavage is a relatively simple "library" approach for epitope mapping in which possible overlapping fragments are screened with the antibody on Western blots.
HAMM H. E., PORCHIA F, MAZZONI, MARIA ROSA   +2 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope [PDF]

, 1991
The regulatory immediate-early (IE) protein pp89 of murine cytomegalovirus induces CD8+ T lymphocytes that protect against lethal murine cytomegalovirus infection.
Ulrich, H. Koszinowski, Koszinowski, Ulrich H., Messerle, Martin, Matthias J. Reddehase, Hansjurgen Volkmer, Reddehase, Matthias J., Del Val, Margarita, Margarita Del Val, Martin Messerle, Volkmer, Hansjürgen, Hans-jurgen Schlicht, Schlicht, Hans-Jürgen   +12 more
core  

Epitope Mapping of Antibodies Using Bacterial Cell Surface Display of Gene Fragment Libraries

, 2018
The unique property of specific high affinity binding to more or less any target of interest has made antibodies tremendously useful in numerous applications.
Rockberg, Johan,, Anna-Luisa Volk, Johan Rockberg, Volk, Anna-Luisa,, Hu, Francis Jingxin,, Francis Jingxin Hu   +5 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Predicting T cell receptor functionality against mutant epitopes

Cell Genomics
Summary: Cancer cells and pathogens can evade T cell receptors (TCRs) via mutations in immunogenic epitopes. TCR cross-reactivity (i.e., recognition of multiple epitopes with sequence similarities) can counteract such escape but may cause severe side ...
Felix Drost, Emilio Dorigatti, Adrian Straub, Philipp Hilgendorf, Karolin I. Wagner, Kersten Heyer, Marta López Montes, Bernd Bischl, Dirk H. Busch, Kilian Schober, Benjamin Schubert   +10 more
doaj   +1 more source

Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone

mSphere, 2017
Despite the clinical relevance, dengue virus (DENV) research has been hampered by the absence of robust reverse genetic systems to manipulate the viral serotypes for propagation and generation of mutant viruses.
Emily N. Gallichotte, Vineet D. Menachery, Boyd L. Yount, Douglas G. Widman, Kenneth H. Dinnon, Steven Hartman, Aravinda M. de Silva, Ralph S. Baric   +7 more
doaj   +1 more source