Results 81 to 90 of about 607,096 (382)

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses [PDF]

, 2021
Katie E. Lineburg, Emma J. Grant, Srividhya Swaminathan, Demetra S.M. Chatzileontiadou, Christopher Szeto, Hannah Sloane, Archana Panikkar, Jyothy Raju, Pauline Crooks, Sweera Rehan, Andrea Nguyen, Lea Lekieffre, Michelle A. Neller, Zhen Tong, Dhilshan Jayasinghe, Keng Yih Chew, Christian A. Lobos, Hanim Halim, Jacqueline M. Burrows, Alan Riboldi‐Tunnicliffe, Weisan Chen, Lloyd D’Orsogna, Rajiv Khanna, Kirsty R. Short, Corey Smith, Stéphanie Gras   +25 more
openalex   +1 more source

Identification of Two Critical Contact Residues in a Pathogenic Epitope from Tetranectin for Monoclonal Antibody Binding and Preparation of Single-Chain Variable Fragments

Biomolecules
Sepsis is a fetal disease that requires a clear diagnostic biomarker for timely antibiotic treatment. Recent research has identified a pyroptosis-inducing epitope known as P5-5 in tetranectin (TN), a plasma protein produced by monocytes.
Juncheng Wang, Meng Liu, Rukhshan Zahid, Wenjie Zhang, Zecheng Cai, Yan Liang, Die Li, Jiasheng Hao, Yuekang Xu   +8 more
doaj   +1 more source

Immunoinformatic analysis of glycoprotein from bovine ephemeral fever virus

Biomedical and Biotechnology Research Journal, 2018
Background: Bovine ephemeral fever virus (BEFV) is an arthropod-borne virus that is highly infective for cattle and water buffalo. The infection has important economic losses and is common in tropical and subtropical regions.
Mehran Bakhshesh, Mohammad Mehdi Ranjbar, Shokoofeh Almasi   +2 more
doaj   +1 more source

A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding

bioRxiv, 2019
Antibody-antigen binding relies on the specific interaction of amino acids at the paratope-epitope interface. It has been a long-standing question of whether antibody-antigen binding is predictable.
R. Akbar, Philippe A. Robert, Milena Pavlović, J. Jeliazkov, I. Snapkov, Andrei Slabodkin, Cédric R. Weber, Lonneke Scheffer, Enkelejda Miho, I. H. Haff, Dag Trygve Tryslew Haug, F. Lund-Johansen, Yana Safonova, G. K. Sandve, V. Greiff   +14 more
semanticscholar   +1 more source

CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell lines [PDF]

, 2005
There is considerable interest in the potential of Epstein-Barr virus (EBV) latent antigen-specific CD4\(^+\) T cells to act as direct effectors controlling EBV-induced B lymphoproliferations.
Brooks, J., Gudgeon, N. H., Haigh, T. A., Houssaint, E., Landais, E., Lee, S. P., Leen, A. M., Long, H. M., Rickinson, A. B., Taylor, G. S., Tsang, C.-W.   +10 more
core   +2 more sources

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Predicting T cell receptor functionality against mutant epitopes

Cell Genomics
Summary: Cancer cells and pathogens can evade T cell receptors (TCRs) via mutations in immunogenic epitopes. TCR cross-reactivity (i.e., recognition of multiple epitopes with sequence similarities) can counteract such escape but may cause severe side ...
Felix Drost, Emilio Dorigatti, Adrian Straub, Philipp Hilgendorf, Karolin I. Wagner, Kersten Heyer, Marta López Montes, Bernd Bischl, Dirk H. Busch, Kilian Schober, Benjamin Schubert   +10 more
doaj   +1 more source

Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone

mSphere, 2017
Despite the clinical relevance, dengue virus (DENV) research has been hampered by the absence of robust reverse genetic systems to manipulate the viral serotypes for propagation and generation of mutant viruses.
Emily N. Gallichotte, Vineet D. Menachery, Boyd L. Yount, Douglas G. Widman, Kenneth H. Dinnon, Steven Hartman, Aravinda M. de Silva, Ralph S. Baric   +7 more
doaj   +1 more source

The immune epitope database (IEDB) 3.0

Nucleic Acids Res., 2014
The IEDB, www.iedb.org, contains information on immune epitopes—the molecular targets of adaptive immune responses—curated from the published literature and submitted by National Institutes of Health funded epitope discovery efforts.
R. Vita, James A. Overton, J. Greenbaum, J. Ponomarenko, J. Clark, Jason R. Cantrell, D. Wheeler, Joseph L. Gabbard, D. Hix, A. Sette, Bjoern Peters   +10 more
semanticscholar   +1 more source