Results 231 to 240 of about 1,474,718 (406)

Mapping of B-cell epitopes on the outer membrane P2 porin protein of Haemophilus influenzae by using recombinant proteins and synthetic peptides [PDF]

, 1991
Diana Martı́n, Robert S. Munson, Susan Grass, P Chong, Josée Hamel, Gloria Zobrist, M. Klein, Bernard R. Brodeur   +7 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Monoclonal antibody and B-cell epitope mapping of the VP7 protein in bluetongue virus. [PDF]

Virol J
Hu XB, Xu J, Zhang Y, Meng FH, Tian ZC, Guan GQ, Luo JX, Yin H, Du JZ.   +8 more
europepmc   +1 more source

B cell responses to paramyosin. Isotypic analysis and epitope mapping of filarial paramyosin in patients with onchocerciasis. [PDF]

, 1990
Christopher Steel, Ronald J. Limberger, Larry McReynolds, Eric A. Ottesen, Thomas B. Nutman   +4 more
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Epitope Mapping of Anti-Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients. [PDF]

Ann Clin Transl Neurol
Abdelhadi AA, Ogata H, Zhang X, Tashiro T, Yamasaki R, Kira JI, Isobe N.   +6 more
europepmc   +1 more source

Epitope mapping and a cocktail of monoclonal antibodies to achieve full detection coverage of potato virus Y. [PDF]

Plant Biotechnol J, 2023
Zhao CL, Zhu Q, Mu XQ, Geng C, Tian YP, Yuan XF, Yan ZY, Li XD.   +7 more
europepmc   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Epitope Mapping with Sidewinder: An XL-MS and Structural Modeling Approach. [PDF]

Int J Mol Sci
Ströbaek J, Tang D, Gueto-Tettay C, Gomez Toledo A, Olofsson B, Hartman E, Heusel M, Malmström J, Malmström L.   +8 more
europepmc   +1 more source

Protocol for analyzing antibody responses to glycoprotein antigens using electron-microscopy-based polyclonal epitope mapping. [PDF]

STAR Protoc, 2023
Turner HL, Jackson AM, Richey ST, Sewall LM, Antanasijevic A, Hangartner L, Ward AB.   +6 more
europepmc   +1 more source