Results 101 to 110 of about 1,625,834 (280)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A voting mechanism-based linear epitope prediction system for the host-specific Iridoviridae family
BMC Bioinformatics, 2019 Background The Iridoviridae family is categorized into five genera and clustered into two subfamilies: Alphairidovirinae includes Lymphocystivirus, Ranavirus (GIV), and Megalocystivirus (TGIV), which infect vertebrate hosts and Betairidovirinae includes ...
Tao-Chuan Shih +4 more
doaj +1 more source
Predictor servers used for MHC-I epitope binding prediction.
, 2018 Predictor servers used for MHC-I epitope binding prediction.
Heidar Ali Panahi (5892656) +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Frontiers in Immunology, 2019 B-cells can neutralize pathogenic molecules by targeting them with extreme specificity using receptors secreted or expressed on their surface (antibodies).
Martin Closter Jespersen +5 more
doaj +1 more source
EpiJen: a server for multistep T cell epitope prediction [PDF]
, 2006 Background The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated with antigen processing (TAP) to the endoplasmic reticulum (ER), where ...
Guan Pingping +8 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
T-Cell Epitope-Based Vaccines: A Promising Strategy for Prevention of Infectious Diseases
VaccinesWith the development of novel vaccine strategies, T-cell epitope-based vaccines have become promising prophylactic and therapeutic tools against infectious diseases that cannot be controlled via traditional vaccines.
Xin Song +4 more
doaj +1 more source
Predictive Algorithms and T Cell Epitope Mapping [PDF]
The Journal of Immunology, 2004 In a recent paper, Pelte et al. ([1][1]) used predictive algorithms ([2][2], [3][3]) and ex vivo T cell assays to map potential epitopes from HCMV. Of the 261 peptides tested, only one peptide stimulated T cells that failed to stabilize HLA-A2 expression on T2 cells. Pelte et al.
openaire +3 more sources