Results 91 to 100 of about 1,625,834 (280)

Characterizing Epitope Binding Regions of Entire Antibody Panels by Combining Experimental and Computational Analysis of Antibody: Antigen Binding Competition

Molecules, 2020
Vaccines and immunotherapies depend on the ability of antibodies to sensitively and specifically recognize particular antigens and specific epitopes on those antigens.
Benjamin D. Brooks, Adam Closmore, Juechen Yang, Michael Holland, Tina Cairns, Gary H. Cohen, Chris Bailey-Kellogg   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

DRREP: deep ridge regressed epitope predictor

BMC Genomics, 2017
Introduction The ability to predict epitopes plays an enormous role in vaccine development in terms of our ability to zero in on where to do a more thorough in-vivo analysis of the protein in question.
Gene Sher, Degui Zhi, Shaojie Zhang
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Deep learning of antibody epitopes using positional permutation vectors

Computational and Structural Biotechnology Journal
Background: The accurate computational prediction of B cell epitopes can vastly reduce the cost and time required for identifying potential epitope candidates for the design of vaccines and immunodiagnostics.
Ioannis Vardaxis, Boris Simovski, Irantzu Anzar, Richard Stratford, Trevor Clancy   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Active Learning Framework for Cost-Effective TCR-Epitope Binding Affinity Prediction [PDF]

, 2023
T cell receptors (TCRs) are critical components of adaptive immune systems, responsible for responding to threats by recognizing epitope sequences presented on host cell surface.
Bang, Seojin, Lee, Heewook, Zhang, Pengfei   +2 more
core   +1 more source

Improving B-cell epitope prediction

Drug Discovery Today
The prediction of antibody binding residues of an antigen is essential for understanding the immune response mechanisms and advancing antibody therapeutics. By definition, each epitope is the binding site of a specific antibody; however, many prediction methods are antibody-agnostic, and thus need only the structure of the antigen.
Hao Yu, Diane Joseph-McCarthy, Sandor Vajda   +2 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pan-prediction of major histocompatibility complex class II–restricted epitopes across species via an AlphaFold-based quantification scheme

hLife
The high polymorphism of histocompatibility complex class II (MHC-II) alleles and limited immunopeptidomic data hinder pan-species epitope prediction. In this study, leveraging the predictive power of AlphaFold (AF) and the conserved structural features ...
Suqiu Wang, Lingming Kong, Dongmei Hu, Liangzhen Zheng, Caiyi Fei, Liubao Du, Ziche Tang, Malgorzata A. Garstka, Onur Serçinoğlu, Lifeng Zhang, Sheng Wang, Shi Xu, Hanchun Yang, Nianzhi Zhang   +13 more
doaj   +1 more source