Results 71 to 80 of about 1,625,834 (280)

The Cancer Epitope Database and Analysis Resource (CEDAR): current capabilities and future directions

Frontiers in Oncology
Cancer epitopes, the molecular structures recognized by T and B cells at the tumor interface, are central to understanding antitumor immunity and developing immunotherapies.
Zeynep Koşaloğlu-Yalçın, Ibel Carri, Daniel Marrama, Eve Richardson, Jason Greenbaum, Nina Blazseka, Randi Vita, Hannah Carter, Morten Nielsen, Bjoern Peters, Bjoern Peters, Alessandro Sette, Alessandro Sette   +12 more
doaj   +1 more source

Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system.

PLoS Computational Biology, 2020
T cell epitope candidates are commonly identified using computational prediction tools in order to enable applications such as vaccine design, cancer neoantigen identification, development of diagnostics and removal of unwanted immune responses against ...
Sinu Paul, Nathan P Croft, Anthony W Purcell, David C Tscharke, Alessandro Sette, Morten Nielsen, Bjoern Peters   +6 more
doaj   +1 more source

Discontinuous Epitope Mapping of Antibodies Using Bacterial Cell Surface Display of Folded Domains

, 2018
Knowledge of the exquisite-binding surface of an antibody on its target protein is of great value, in particular for therapeutic antibodies for understanding method of action and for stratification of patients carrying the necessary epitope for desired ...
Rockberg, Johan,, Anna-Luisa Volk, Johan Rockberg, Volk, Anna-Luisa,   +3 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Benchmarking of T cell receptor-epitope predictors with ePytope-TCR

Cell Genomics
Summary: Understanding the recognition of disease-derived epitopes through T cell receptors (TCRs) has the potential to serve as a stepping stone for the development of efficient immunotherapies and vaccines. While a plethora of sequence-based prediction
Felix Drost, Anna Chernysheva, Mahmoud Albahah, Katharina Kocher, Kilian Schober, Benjamin Schubert   +5 more
doaj   +1 more source

Epitope Labeling of Histidine Decarboxylase in Drosophila melanogaster [PDF]

, 2006
Histidine decarboxylase (HDC) plays a critical role in the synthesis of histamine, a central nervous system neurotransmitter used by both vertebrates and invertebrates.
Payne, Stephanie A. N.
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

HIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.

PLoS Pathogens, 2013
Several recent large clinical trials evaluated HIV vaccine candidates that were based on recombinant adenovirus serotype 5 (rAd-5) vectors expressing HIV-derived antigens. These vaccines primarily elicited T-cell responses, which are known to be critical
Tomer Hertz, Hasan Ahmed, David P Friedrich, Danilo R Casimiro, Steven G Self, Lawrence Corey, M Juliana McElrath, Susan Buchbinder, Helen Horton, Nicole Frahm, Michael N Robertson, Barney S Graham, Peter Gilbert   +12 more
doaj   +1 more source

Epitope-specific antibody responses in gD2 immunized guinea pigs and humans.

, 2018
Epitope-specific antibody responses in gD2 immunized guinea pigs and humans.
Harvey M. Friedman (3682018), Lauren M. Hook (3682027), Tina M. Cairns (4110190), Sita Awasthi (3682030), Gary H. Cohen (203335), Roselyn J. Eisenberg (203337), Benjamin D. Brooks (714084), Noah T. Ditto (4110187)   +7 more
core   +1 more source