Results 151 to 160 of about 1,625,834 (280)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Cancer epitope prediction tools and analysis pipelines in CEDAR. [PDF]

Nucleic Acids Res
Carri I, Greenbaum J, Yan Z, Kim K, Kim H, Premlal ALR, Marrama D, Blazeska N, Carter H, Lee KH, Sears T, Nielsen M, Sette A, Peters B, Koşaloğlu-Yalçın Z.   +14 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Pocket restraints guided by B-cell epitope prediction improve Chai-1 antibody-antigen structure modeling. [PDF]

Protein Sci
Clifford JN, Nielsen M.
europepmc   +1 more source

epitope1D: accurate taxonomy-aware B-cell linear epitope prediction. [PDF]

Brief Bioinform, 2023
da Silva BM, Ascher DB, Pires DEV.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Classification Evolution and Epitope Prediction of the Porcine Epidemic Diarrhea Virus (PEDV) Spike Protein in Thailand (2008-2024): Updated Insights for Preventive Strategies. [PDF]

Animals (Basel)
Stott CJ, Mahawan T, Piñeyro P, Lin H, Tantituvanont A, Nilubol D.   +5 more
europepmc   +1 more source

Retracted: Machine Learning-Based Ensemble Model for Zika Virus T-Cell Epitope Prediction. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

SEMA: Antigen B-cell conformational epitope prediction using deep transfer learning [PDF]

Front Immunol, 2022
Shashkova TI, Umerenkov D, Salnikov M, Strashnov PV, Konstantinova AV, Lebed I, Shcherbinin DN, Asatryan MN, Kardymon OL, Ivanisenko NV.   +9 more
europepmc   +2 more sources