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Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle [PDF]

open access: yes, 2009
gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be ...
A Rickinson   +51 more
core   +21 more sources

Mutation Profile of HPV16 L1 and L2 Genes in Different Geographic Areas

open access: yesViruses, 2022
The causal relationship between HPV and cervical cancer in association with the high prevalence of high risk HPV genotypes led to the design of HPV vaccines based on the major capsid L1 protein.
Dimitris Tsakogiannis   +9 more
doaj   +1 more source

AI Aided Design of Epitope-Based Vaccine for the Induction of Cellular Immune Responses Against SARS-CoV-2

open access: yesFrontiers in Genetics, 2021
The heavy burden imposed by the COVID-19 pandemic on our society triggered the race toward the development of therapies or preventive strategies. Among these, antibodies and vaccines are particularly attractive because of their high specificity, low ...
Giovanni Mazzocco   +13 more
doaj   +1 more source

Clinical characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease according to their epitopes

open access: yesFrontiers in Neurology, 2023
BackgroundThe detection of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Ab) is essential for the diagnosis of MOG-Ab-associated disease (MOGAD). The clinical implications of different epitopes recognized by MOG-Ab are largely unknown.
Jin Myoung Seok   +13 more
doaj   +1 more source

Epitope Tagging [PDF]

open access: yesBioTechniques, 2008
Epitope tagging is widely used in the characterization of newly discovered proteins. This review presents an overview of how the technique evolved and how it is being used today, with a focus on its use in the study of protein-protein interactions. In addition, the evolution of the technique for proteomic analyses is described.
openaire   +4 more sources

Antibody screening reveals antigenic proteins involved in Talaromyces marneffei and human interaction

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
Talaromycosis is a fungal infection that generally affects immunocompromised hosts and is one of the most frequent systemic mycoses in HIV patients, especially in endemic areas such as Southeast Asia.
Tanaporn Wangsanut   +2 more
doaj   +1 more source

Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species [PDF]

open access: yes, 2019
The high global demand of wheat and its subsequent consumption arise from the physicochemical properties of bread dough and its contribution to the protein intake in the human diet.
Barro Losada, Francisco   +8 more
core   +1 more source

Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]

open access: yes, 2013
John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D   +2 more
core   +1 more source

Urinary Peptides As a Novel Source of T Cell Allergen Epitopes

open access: yesFrontiers in Immunology, 2018
Mouse allergy in both laboratory workers and in inner-city children is associated with allergic rhinitis and asthma, posing a serious public health concern.
Ricardo da Silva Antunes   +14 more
doaj   +1 more source

B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development

open access: yesViruses, 2023
Failure of cross-protection among interserotypes and intratypes of foot-and-mouth disease virus (FMDV) is a big threat to endemic countries and their prevention and control strategies.
Qian Li   +4 more
doaj   +1 more source

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