Results 1 to 10 of about 343,270 (209)

A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies [PDF]

, 2010
A promising direction in drug development is to exploit the ability of natural killer cells to kill antibody-labeled target cells. Monoclonal antibodies and drugs designed to elicit this effect typically bind cell-surface epitopes that are overexpressed on target cells but also present on other cells.
A Ashkenazi, A Iannello, AF Wells, AJ da Silva, BJ Scallon, Byron Goldstein, C Anderson, C Fewtrell, C Wofsy, CN Ellis, DA Hammer, Daniel Coombs, DM Zhu, DM Zhu, E Jones, F Chamian, G Bell, G Majeau, GI Bell, H Koon, J Cooper, J Galon, JA Trapani, JY Shao, K Maenaka, L Arnould, LJ Harris, LM Friedman, Lucienne Chatenoud, M Dustin, MA Ghetie, Michael L. Dustin, MJ Rosenbluth, ML Dustin, ML Dustin, ML Dustin, RA Byrn, RA Clynes, Ryan N. Gutenkunst, S Chandrasekhar, S Preithner, SE Chesla, TA Waldmann, Toby Starr, Y Kaizuka, YT Bryceson   +45 more
arxiv   +6 more sources

Epitope prediction improved by multitask support vector machines [PDF]

We use various multitask kernels in order to improve MHC-I-peptide binding prediction, in particular for MHC alleles for which few training data is available. (05/02/2007), 2007
Motivation: In silico methods for the prediction of antigenic peptides binding to MHC class I molecules play an increasingly important role in the identification of T-cell epitopes. Statistical and machine learning methods, in particular, are widely used to score candidate epitopes based on their similarity with known epitopes and non epitopes.
Jacob, Laurent, Vert, Jean-Philippe
arxiv   +3 more sources

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis. [PDF]

Front Immunol
BackgroundUveitis, characterized by intraocular inflammation, poses significant clinical challenges, often leading to vision impairment or blindness. Herpes Simplex Virus type 1 (HSV-1) is a major cause of virus-induced uveitis. This study aims to design
Cao H, Cao Z, Han Y, Shan J.
europepmc   +2 more sources

Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis [PDF]

, 2015
Immunotherapy treatments for cancer are becoming increasingly successful, however to further improve our understanding of the T-cell recognition involved in effective responses and to encourage moves towards the development of personalised treatments for
Arno, Matthew, Banham, Alison H., Bonney, Stephanie A., Brooks, Suzanne E., Elliott, Tim J., Guinn, Barbara-Ann, Khan, Ghazala, Lee, Cindy, Li, Demin, Mills, Ken I., Mufti, Ghulam J., Orchard, Kim H., Publicover, Amy, Pulford, Karen, Rammensee, Hans-Georg, Sigurdardottir, Dagmar, Smits, Evelien L.J., van Tendeloo, Viggo   +17 more
core   +25 more sources

Recombinantly Expressed Chimeric Fibers Demonstrate Discrete Type-Specific Neutralizing Epitopes in the Fowl Aviadenovirus E (FAdV-E) Fiber, Promoting the Optimization of FAdV Fiber Subunit Vaccines towards Cross-Protection in vivo

Microbiology Spectrum, 2022
Vaccines against inclusion body hepatitis in chickens are complicated by the involvement of antigenically diverse fowl adenovirus types. Though immunization with fiber protein confers robust protection, type specificity of fiber antibodies is an obstacle
Anna Schachner, Carlotta De Luca, Sarah Heidl, Michael Hess   +3 more
doaj   +1 more source

Computational Approach for Predicting Common Epitopes in the VP1 Structural Protein of Enterovirus Serotypes EV-D68, EV-D70, and EV-A71

Journal of Pure and Applied Microbiology, 2021
The three human Enterovirus serotypes D-68, D-70, and A-71, are common pathogens that are transmitted by fecal-oral and aerosol routes. These positive RNA viruses were known to exhibit high levels of genetic diversity and variability.
Rihabe Boussettine, Yassine Kasmi, Najwa Hassou, Hlima Bessi, Moulay Mustapha Ennaji   +4 more
doaj   +1 more source

AI Aided Design of Epitope-Based Vaccine for the Induction of Cellular Immune Responses Against SARS-CoV-2

Frontiers in Genetics, 2021
The heavy burden imposed by the COVID-19 pandemic on our society triggered the race toward the development of therapies or preventive strategies. Among these, antibodies and vaccines are particularly attractive because of their high specificity, low ...
Giovanni Mazzocco, Iga Niemiec, Alexander Myronov, Alexander Myronov, Piotr Skoczylas, Jan Kaczmarczyk, Anna Sanecka-Duin, Katarzyna Gruba, Katarzyna Gruba, Paulina Król, Michał Drwal, Marian Szczepanik, Krzysztof Pyrc, Piotr Stȩpniak   +13 more
doaj   +1 more source

Characterization of the B-Cell Epitopes of Echinococcus granulosus Histones H4 and H2A Recognized by Sera From Patients With Liver Cysts

Frontiers in Cellular and Infection Microbiology, 2022
Cystic echinococcosis (CE) is a zoonotic disease worldwide distributed, caused by the cestode Echinococcus granulosus sensu lato (E. granulosus), with an incidence rate of 50/100,000 person/year and a high prevalence in humans of 5-10%.
Andrea Maglioco, Andrea Maglioco, Facundo A. Agüero, Facundo A. Agüero, María Pía Valacco, Alejandra Juárez Valdez, Margot Paulino, Alicia G. Fuchs, Alicia G. Fuchs   +8 more
doaj   +1 more source

CoronaVR: A Computational Resource and Analysis of Epitopes and Therapeutics for Severe Acute Respiratory Syndrome Coronavirus-2

Frontiers in Microbiology, 2020
In December 2019, the Chinese city of Wuhan was the center of origin of a pneumonia-like disease outbreak with an unknown causative pathogen. The CDC, China, managed to track the source of infection to a novel coronavirus (2019-nCoV; SARS-CoV-2) that ...
Amit Kumar Gupta, Md. Shoaib Khan, Shubham Choudhury, Adhip Mukhopadhyay, Adhip Mukhopadhyay, Sakshi, Sakshi, Amber Rastogi, Amber Rastogi, Anamika Thakur, Anamika Thakur, Pallawi Kumari, Manmeet Kaur, Shalu, Chanchal Saini, Vandna Sapehia, Barkha, Pradeep Kumar Patel, Kailash T. Bhamare, Manoj Kumar, Manoj Kumar   +20 more
doaj   +1 more source

TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks [PDF]

Bioinformatics 37 (2021): i237-i244, 2021
Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope ...
arxiv   +1 more source