Results 1 to 10 of about 505,722 (385)

Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis [PDF]

, 2015
Immunotherapy treatments for cancer are becoming increasingly successful, however to further improve our understanding of the T-cell recognition involved in effective responses and to encourage moves towards the development of personalised treatments for
Arno, Matthew, Banham, Alison H., Bonney, Stephanie A., Brooks, Suzanne E., Elliott, Tim J., Guinn, Barbara-Ann, Khan, Ghazala, Lee, Cindy, Li, Demin, Mills, Ken I., Mufti, Ghulam J., Orchard, Kim H., Publicover, Amy, Pulford, Karen, Rammensee, Hans-Georg, Sigurdardottir, Dagmar, Smits, Evelien L.J., van Tendeloo, Viggo   +17 more
core   +13 more sources

Computational Approach for Predicting Common Epitopes in the VP1 Structural Protein of Enterovirus Serotypes EV-D68, EV-D70, and EV-A71

Journal of Pure and Applied Microbiology, 2021
The three human Enterovirus serotypes D-68, D-70, and A-71, are common pathogens that are transmitted by fecal-oral and aerosol routes. These positive RNA viruses were known to exhibit high levels of genetic diversity and variability.
Rihabe Boussettine, Yassine Kasmi, Najwa Hassou, Hlima Bessi, Moulay Mustapha Ennaji   +4 more
doaj   +1 more source

Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]

, 2020
ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco, Cole, Robert N, Darrah, Erika, Fava, Andrea, Guhr, Tara, McMahan, Zsuzsanna H, O'Meally, Robert N, Shah, Ami A, Tiniakou, Eleni, Wigley, Fredrick M   +9 more
core   +1 more source

Recombinantly Expressed Chimeric Fibers Demonstrate Discrete Type-Specific Neutralizing Epitopes in the Fowl Aviadenovirus E (FAdV-E) Fiber, Promoting the Optimization of FAdV Fiber Subunit Vaccines towards Cross-Protection in vivo

Microbiology Spectrum, 2022
Vaccines against inclusion body hepatitis in chickens are complicated by the involvement of antigenically diverse fowl adenovirus types. Though immunization with fiber protein confers robust protection, type specificity of fiber antibodies is an obstacle
Anna Schachner, Carlotta De Luca, Sarah Heidl, Michael Hess   +3 more
doaj   +1 more source

AI Aided Design of Epitope-Based Vaccine for the Induction of Cellular Immune Responses Against SARS-CoV-2

Frontiers in Genetics, 2021
The heavy burden imposed by the COVID-19 pandemic on our society triggered the race toward the development of therapies or preventive strategies. Among these, antibodies and vaccines are particularly attractive because of their high specificity, low ...
Giovanni Mazzocco, Iga Niemiec, Alexander Myronov, Alexander Myronov, Piotr Skoczylas, Jan Kaczmarczyk, Anna Sanecka-Duin, Katarzyna Gruba, Katarzyna Gruba, Paulina Król, Michał Drwal, Marian Szczepanik, Krzysztof Pyrc, Piotr Stȩpniak   +13 more
doaj   +1 more source

Characterization of the B-Cell Epitopes of Echinococcus granulosus Histones H4 and H2A Recognized by Sera From Patients With Liver Cysts

Frontiers in Cellular and Infection Microbiology, 2022
Cystic echinococcosis (CE) is a zoonotic disease worldwide distributed, caused by the cestode Echinococcus granulosus sensu lato (E. granulosus), with an incidence rate of 50/100,000 person/year and a high prevalence in humans of 5-10%.
Andrea Maglioco, Andrea Maglioco, Facundo A. Agüero, Facundo A. Agüero, María Pía Valacco, Alejandra Juárez Valdez, Margot Paulino, Alicia G. Fuchs, Alicia G. Fuchs   +8 more
doaj   +1 more source

In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate [PDF]

Vaccine Research, 2020
Introduction: The development of a vaccine against Staphylococcus aureus has proven to be much more difficult than expected. In this study, we considered and analyzed a mutant Toxic Shock Syndrome Toxin-1 (TSST-1) as a potential vaccine candidate ...
Mohsen Nazari, Farzad Badmasti
doaj   +1 more source

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses. [PDF]

, 2015
Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains ...
Allen, S, Bansal, A, Carlson, J, Dilernia, D, Du, VY, Erdmann, N, Gilmour, J, Goepfert, PA, Heath, S, Hunter, E, Jureka, A, Lakhi, S, Schaefer, M, Sidney, J, Sterrett, S, Tang, J, Yue, L   +16 more
core   +7 more sources

Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins

Frontiers in Immunology, 2018
BackgroundIt has been shown earlier that there is a rise in the levels of autoantibodies and T cell response to cytoskeletal proteins in leprosy. Our group recently demonstrated a rise in both T and B cell responses to keratin and myelin basic protein in
Itu Singh, Asha Ram Yadav, Keshar Kunja Mohanty, Kiran Katoch, Prashant Sharma, Vinay Kumar Pathak, Deepa Bisht, Umesh D. Gupta, Utpal Sengupta   +8 more
doaj   +1 more source

Interaction Between Virus-Like Particles (VLPs) and Pattern Recognition Receptors (PRRs) From Dendritic Cells (DCs): Toward Better Engineering of VLPs

Frontiers in Immunology, 2020
Virus-like particles (VLPs) have been shown to be strong activators of dendritic cells (DCs). DCs are the most potent antigen presenting cells (APCs) and their activation prompts the priming of immunity mediators based on B and T cells.
Jesús Zepeda-Cervantes, Josué Orlando Ramírez-Jarquín, Luis Vaca, Luis Vaca   +3 more
doaj   +1 more source