Results 1 to 10 of about 50 (48)
The epitope recognized by rituximab [PDF]
Blood, 2006 AbstractRituximab is a monoclonal antibody widely used in the treatment of malignant lymphoma and autoimmunity. Its epitope within the B-cell antigen CD20 is largely unknown. We used phage display libraries to select peptides binding to rituximab. Enriched peptides showed 2 sequence patterns: one motif (CALMIANSC) is related to (170)ANPS(173) within ...
Binder, Mascha +4 more
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BioTechniques, 2008 Epitope tagging is widely used in the characterization of newly discovered proteins. This review presents an overview of how the technique evolved and how it is being used today, with a focus on its use in the study of protein-protein interactions. In addition, the evolution of the technique for proteomic analyses is described.
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Current Opinion in Immunology, 1996 Epitope (determinant) spreading is the development of immune responses to endogenous epitopes secondary to the release of self antigens during a chronic autoimmune or inflammatory response. The past year has seen considerable advances in our understanding of the contribution of epitope spreading to the chronic pathogenesis of experimental T-cell ...
Vanderlugt, Carol J, Miller, Stephen D
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BioDrugs, 2007 Antibodies are an effective line of defense in preventing infectious diseases. Highly potent neutralizing antibodies can intercept a virus before it attaches to its target cell and, thus, inactivate it. This ability is based on the antibodies' specific recognition of epitopes, the sites of the antigen to which antibodies bind.
Yael Weiss +4 more
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IgE-binding epitopes: a reappraisal [PDF]
Allergy, 2011 Here, we discuss various questions related to IgE epitopes: What are the technical possibilities and pitfalls, what is currently known, how can we put this information into hypothetical frameworks and the unavoidable question: how useful is this information for patient care or allergenicity prediction?
Aalberse, R.C., Crameri R.
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Finding Epitopes with Computers
Chemistry & Biology, 2013 The goal of structural vaccinology is to enable the design and engineering of improved antigens. In a recent issue of Chemistry & Biology, Gourlay and colleagues provided evidence that structure-based computational methods allow prediction of B cell epitopes, a crucial step for antigen selection and optimization in vaccine development.
Rino Rappuoli, Enrico Malito
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Journal of Pharmacological Sciences, 2007 The prevailing methods to predict T-cell epitopes are reviewed. Motif matching, matrix, support vector machine (SVM), and empirical scoring function methods are mainly reviewed; and the thermodynamic integration (TI) method using all-atom molecular dynamics (MD) simulation is mentioned briefly.
Takuya Takahashi, Hiromichi Tsurui
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Defining the epichromatin epitope [PDF]
Nucleus, 2017 Epichromatin is identified by immunostaining fixed and permeabilized cells with particular bivalent anti-nucleosome antibodies (mAbs PL2-6 and 1H6). During interphase, epichromatin resides adjacent to the inner nuclear membrane; during mitosis, at the outer surface of mitotic chromosomes.
Travis J. Gould +6 more
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An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction [PDF]
Journal of Immunology Research, 2016 Identification of B-cell epitopes is a fundamental step for development of epitope-based vaccines, therapeutic antibodies, and diagnostic tools. Epitope-based antibodies are currently the most promising class of biopharmaceuticals. In the last decade, in-depth in silico analysis and categorization of the experimentally identified epitopes stimulated ...
Lenka Potocnakova +2 more
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Epitope Specific Antibodies and T Cell Receptors in the Immune Epitope Database [PDF]
Frontiers in Immunology, 2018 The Immune Epitope Database (IEDB) is a free public resource which catalogs experiments characterizing immune epitopes. To accommodate data from next generation repertoire sequencing experiments, we recently updated how we capture and query epitope specific antibodies and T cell receptors.
Swapnil Mahajan +13 more
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