Results 21 to 30 of about 341,338 (291)

Seeking Flavivirus Cross-Protective Immunity

Frontiers in Immunology, 2019
The Flavivirus genus is composed by viral serocomplexes with relevant global epidemiological impact. Many areas of the world present both, vector fauna and geographical conditions compatible with co-circulation, importing, emergence, and epidemics of ...
Lorrany dos Santos Franco, Letícia Tsieme Gushi, Wilson Barros Luiz, Jaime Henrique Amorim, Jaime Henrique Amorim   +4 more
doaj   +1 more source

Preparation and Identification of a Monoclonal Antibody against the Pseudorabies Virus gE Glycoprotein through a Novel Strategy

Veterinary Sciences, 2023
Since 2011, pseudorabies virus (PRV) has recurred in several vaccinated pig farms in China. PRV variants with high virulence were found to be the main cause of the outbreaks.
Zhenyang Guo, Siyu Zhang, Hu Xu, Wansheng Li, Chao Li, Jing Zhao, Bangjun Gong, Qi Sun, Lirun Xiang, Hongyuan Zhao, Qian Wang, Guohui Zhou, Yandong Tang, Tongqing An, Xuehui Cai, Zhijun Tian, Hongliang Zhang, Jinmei Peng   +17 more
doaj   +1 more source

CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]

, 2018
Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core   +2 more sources

Characterization of the B-Cell Epitopes of Echinococcus granulosus Histones H4 and H2A Recognized by Sera From Patients With Liver Cysts

Frontiers in Cellular and Infection Microbiology, 2022
Cystic echinococcosis (CE) is a zoonotic disease worldwide distributed, caused by the cestode Echinococcus granulosus sensu lato (E. granulosus), with an incidence rate of 50/100,000 person/year and a high prevalence in humans of 5-10%.
Andrea Maglioco, Andrea Maglioco, Facundo A. Agüero, Facundo A. Agüero, María Pía Valacco, Alejandra Juárez Valdez, Margot Paulino, Alicia G. Fuchs, Alicia G. Fuchs   +8 more
doaj   +1 more source

CD4+ Th immunogenicity of the Ascaris spp. secreted products [PDF]

, 2020
Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines.
Bertazzon, Miriam, Ebner, Friederike, Freund, Christian, Hartmann, Susanne, Midha, Ankur, Morrison, Eliot, Álvaro-Benito, Miguel   +6 more
core   +1 more source

Mycobacterium tuberculosis epitope-specific interferon-g production in healthy Brazilians reactive and non-reactive to tuberculin skin test

Memorias do Instituto Oswaldo Cruz, 2014
The interferon (IFN)-γ response to peptides can be a useful diagnostic marker of Mycobacterium tuberculosis (MTB) latent infection.
Bosco Christiano Maciel da Silva, Maria Fernanda Rios Grassi, Raimundo Coutinho, Rita Elizabeth Moreira Mascarenhas, Viviana Nilla Olavarria, Adriana Coutinho-Borgo, Jorge Kalil, Edecio Cunha Neto, Simone Gonçalves Fonseca   +8 more
doaj   +1 more source

Recombinantly Expressed Chimeric Fibers Demonstrate Discrete Type-Specific Neutralizing Epitopes in the Fowl Aviadenovirus E (FAdV-E) Fiber, Promoting the Optimization of FAdV Fiber Subunit Vaccines towards Cross-Protection in vivo

Microbiology Spectrum, 2022
Vaccines against inclusion body hepatitis in chickens are complicated by the involvement of antigenically diverse fowl adenovirus types. Though immunization with fiber protein confers robust protection, type specificity of fiber antibodies is an obstacle
Anna Schachner, Carlotta De Luca, Sarah Heidl, Michael Hess   +3 more
doaj   +1 more source

Inferring HIV escape rates from multi-locus genotype data [PDF]

, 2013
Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells.
Kessinger, Taylor A., Neher, Richard A., Perelson, Alan S.   +2 more
core   +3 more sources

Large Scale Genome Analysis Shows that the Epitopes for Broadly Cross-Reactive Antibodies Are Predominant in the Pandemic 2009 Influenza Virus A H1N1 Strain

Viruses, 2013
The past pandemic strain H1N1 (A (H1N1)pdm09) has now become a common component of current seasonal influenza viruses. It has changed the pre-existing immunity of the human population to succeeding infections.
Edgar E. Lara-Ramírez, Aldo Segura-Cabrera, Ma Isabel Salazar, Mario A. Rodríguez-Pérez, Xianwu Guo   +4 more
doaj   +1 more source

Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses. [PDF]

, 2018
Nanoparticles have attracted considerable interest as cancer vaccine delivery vehicles for inducing sufficient CD8+ T cell-mediated immune responses to overcome the low immunogenicity of the tumor microenvironment.
Kim, Tae Il, Molino, Nicholas M, Neek, Medea, Nelson, Edward L, Tucker, Jo Anne, Wang, Szu-Wen   +5 more
core   +2 more sources