Results 21 to 30 of about 200,545 (260)

Phage Display Detection of Mimotopes that Are Shared Epitopes of Clinically and Epidemiologically Relevant Enterobacteria

Microorganisms, 2020
Background: Escherichia coli and Salmonella are etiologic agents of intestinal infections. A previous study showed the presence of shared epitopes between lipopolysaccharides (LPSs) of E. coli O157 and Salmonella.
Armando Navarro, Delia Licona-Moreno, Alejandro Monsalvo-Reyes, Ulises Hernández-Chiñas, Carlos A. Eslava-Campos   +4 more
doaj   +1 more source

Orf Virus-Based Vaccine Vector D1701-V Induces Strong CD8+ T Cell Response against the Transgene but Not against ORFV-Derived Epitopes

Vaccines, 2020
The potency of viral vector-based vaccines depends on their ability to induce strong transgene-specific immune response without triggering anti-vector immunity.
Alena Reguzova, Michael Ghosh, Melanie Müller, Hanns-Joachim Rziha, Ralf Amann   +4 more
doaj   +1 more source

Epitope Mapping [PDF]

BioDrugs, 2007
Antibodies are an effective line of defense in preventing infectious diseases. Highly potent neutralizing antibodies can intercept a virus before it attaches to its target cell and, thus, inactivate it. This ability is based on the antibodies' specific recognition of epitopes, the sites of the antigen to which antibodies bind.
Gershoni, Jonathan M., Roitburd-Berman, Anna, Siman-Tov, Dror D., Freund, Natalia Tarnovitski, Weiss, Yael   +4 more
openaire   +2 more sources

A Novel Algorithm for Macromolecular Epitope Matching

Algorithms, 2009
Many macromolecules, namely proteins, show functional substructures or epitopes defined by characteristic spatial arrangements of groups of specific atoms or residues.
Stanislav Jakuschev, Daniel Hoffmann
doaj   +1 more source

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis

Frontiers in Immunology
BackgroundUveitis, characterized by intraocular inflammation, poses significant clinical challenges, often leading to vision impairment or blindness. Herpes Simplex Virus type 1 (HSV-1) is a major cause of virus-induced uveitis. This study aims to design
He Cao, Zhi Cao, Yue Han, Jing Shan
doaj   +1 more source

Immunoproteomics Reveals Pathogen’s Antigens Involved in Homo sapiens–Histoplasma capsulatum Interaction and Specific Linear B-Cell Epitopes in Histoplasmosis

Frontiers in Cellular and Infection Microbiology, 2020
Histoplasmosis is one of the most frequent systemic mycosis in HIV patients. In these patients, histoplasmosis has high rates of morbidity/mortality if diagnosis and treatment are delayed.
Marcos Abreu Almeida, Rodrigo Almeida-Paes, Allan Jefferson Guimarães, Richard Hemmi Valente, Célia Maria de Almeida Soares, Rosely Maria Zancopé-Oliveira   +5 more
doaj   +1 more source

Computational Prediction of B-cell Epitopes of Mycobacterium tuberculosis-Implications in Vaccine Design

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2021
Introduction: Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis. Bacillus Calmette-Guérin is the only vaccine available for TB.
Esakkimuthu THANGAMARIAPPAN, Manikandan MOHAN, Krishnan SUNDAR   +2 more
doaj   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source

Revolutionizing the virulent protein Internalin a in Listeria monocytogenes and designing multi epitope-based vaccine via immunoinformatic approaches

CyTA - Journal of Food
This study addresses the crucial protein Internalin A in the development of a possible vaccination against Listeria monocytogenes. A meticulous in silico strategy was used which included physiochemical analysis, epitope prediction, and molecular ...
Tariq Aziz, Muhammad Naveed, Muhammad Aqib Shabbir, Khizra Jabeen, Athina S. Tzora, Eleftherios Bonos, Ioannis Skoufos, Metab Alharbi, Abdullah F Alasmari, Abdulrahman Alshammari   +9 more
doaj   +1 more source

A Basic Molecular Analysis of the Diabetic Antigen GAD by Homology Modelling. Principles of the Method and Understanding of Antigenicity and Binding Sites

Pteridines, 2007
Functional specificity of a protein is linked to its structure. A growing section of bioinformatics deals with the prediction and visualization of protein 3D structures.
Wiltgen Marco, Tilz Gernot P.
doaj   +1 more source