Results 151 to 160 of about 228,208 (297)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Preclinical development of an mRNA-based multiepitope immunotherapeutic for glioblastoma. [PDF]

Cancer Immunol Immunother
Lutz J, Feist RK, Sonntag T, Peguero-Sánchez E, Wolter K, Bick R, Bauer J, Walz JS, Heidenreich R.   +8 more
europepmc   +1 more source

The selectivity of Cathepsin D Suggests an Involvement of the Enzyme in the Generation of T-cell Epitopes

, 1989
Johannes M. van Noort, A C van der Drift
openalex   +1 more source

Formaldehyde sensitivity of a GFAP epitope, removed by extraction of the cytoskeleton with high salt. [PDF]

, 1987
Paul B. Bell, Ingemar Rundquist, Ingemar Svensson, V. Peter Collins   +3 more
openalex   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Epitope mapping strategies for immunogenicity mitigation in streptokinase therapeutics: an in-silico study. [PDF]

Sci Rep
Hajizade MS, Rahbar MR, Kabiri M, Hajimonfarednejad M, Raee MJ.   +4 more
europepmc   +1 more source

Characterization of developmentally regulated epitopes of Schistosoma mansoni egg glycoprotein antigens. [PDF]

, 1985
Johanna Weiß, Mette Strand
openalex   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Immunodominant T cell responses to SARS-CoV-2 nucleocapsid protein in Omicron breakthrough infection post-inactivated vaccination. [PDF]

Virulence
Ning J, Xu Y, Ren Y, Zhang Z, Chen Y, Zeng X, Zhang J, Wu C.   +7 more
europepmc   +1 more source

Serologically defined linear epitopes in the envelope protein of dengue 2 (Jamaica strain 1409) [PDF]

, 1989
John Aaskov, H. Mario Geysen, Thomas Mason   +2 more
openalex   +1 more source