Results 11 to 20 of about 491,390 (408)

Epitope prediction improved by multitask support vector machines [PDF]

We use various multitask kernels in order to improve MHC-I-peptide binding prediction, in particular for MHC alleles for which few training data is available. (05/02/2007), 2007
Motivation: In silico methods for the prediction of antigenic peptides binding to MHC class I molecules play an increasingly important role in the identification of T-cell epitopes. Statistical and machine learning methods, in particular, are widely used to score candidate epitopes based on their similarity with known epitopes and non epitopes.
Jacob, Laurent, Vert, Jean-Philippe
arxiv   +3 more sources

Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis [PDF]

, 2015
Immunotherapy treatments for cancer are becoming increasingly successful, however to further improve our understanding of the T-cell recognition involved in effective responses and to encourage moves towards the development of personalised treatments for
Arno, Matthew, Banham, Alison H., Bonney, Stephanie A., Brooks, Suzanne E., Elliott, Tim J., Guinn, Barbara-Ann, Khan, Ghazala, Lee, Cindy, Li, Demin, Mills, Ken I., Mufti, Ghulam J., Orchard, Kim H., Publicover, Amy, Pulford, Karen, Rammensee, Hans-Georg, Sigurdardottir, Dagmar, Smits, Evelien L.J., van Tendeloo, Viggo   +17 more
core   +29 more sources

Computational Approach for Predicting Common Epitopes in the VP1 Structural Protein of Enterovirus Serotypes EV-D68, EV-D70, and EV-A71

Journal of Pure and Applied Microbiology, 2021
The three human Enterovirus serotypes D-68, D-70, and A-71, are common pathogens that are transmitted by fecal-oral and aerosol routes. These positive RNA viruses were known to exhibit high levels of genetic diversity and variability.
Rihabe Boussettine, Yassine Kasmi, Najwa Hassou, Hlima Bessi, Moulay Mustapha Ennaji   +4 more
doaj   +1 more source

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

Science, 2021
A public anti-COVID antibody repertoire Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells.
William N. Voss, Yixuan J. Hou, N. Johnson, George Delidakis, Jin Eyun Kim, Kamyab Javanmardi, Andrew P. Horton, Foteini Bartzoka, Chelsea J. Paresi, Yuri Tanno, Chia-Wei Chou, Shawn A. Abbasi, Whitney Pickens, Katia George, D. Boutz, Dalton M. Towers, Jonathan R. McDaniel, Daniel Billick, Jule Goike, Lori Rowe, D. Batra, J. Pohl, Justin Lee, Shivaprakash Gangappa, S. Sambhara, M. Gadush, Nianshuang Wang, M. Person, B. Iverson, J. Gollihar, J. Dye, A. Herbert, Ilya J. Finkelstein, R. Baric, J. McLellan, G. Georgiou, Jason J. Lavinder, G. Ippolito   +37 more
semanticscholar   +1 more source

Predicting recognition between T cell receptors and epitopes with TCRGP

PLoS Comput. Biol., 2021
Adaptive immune system uses T cell receptors (TCRs) to recognize pathogens and to consequently initiate immune responses. TCRs can be sequenced from individuals and methods analyzing the specificity of the TCRs can help us better understand individuals ...
Emmi Jokinen, J. Huuhtanen, S. Mustjoki, Markus Heinonen, H. Lähdesmäki   +4 more
semanticscholar   +1 more source

TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks [PDF]

Bioinformatics 37 (2021): i237-i244, 2021
Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope ...
arxiv   +1 more source

Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]

, 2020
ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco, Cole, Robert N, Darrah, Erika, Fava, Andrea, Guhr, Tara, McMahan, Zsuzsanna H, O'Meally, Robert N, Shah, Ami A, Tiniakou, Eleni, Wigley, Fredrick M   +9 more
core   +1 more source

Recombinantly Expressed Chimeric Fibers Demonstrate Discrete Type-Specific Neutralizing Epitopes in the Fowl Aviadenovirus E (FAdV-E) Fiber, Promoting the Optimization of FAdV Fiber Subunit Vaccines towards Cross-Protection in vivo

Microbiology Spectrum, 2022
Vaccines against inclusion body hepatitis in chickens are complicated by the involvement of antigenically diverse fowl adenovirus types. Though immunization with fiber protein confers robust protection, type specificity of fiber antibodies is an obstacle
Anna Schachner, Carlotta De Luca, Sarah Heidl, Michael Hess   +3 more
doaj   +1 more source

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Science, 2020
Preexisting immune response to SARS-CoV-2 Robust T cell responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus occur in most individuals with coronavirus disease 2019 (COVID-19). Several studies have reported that some people
J. Mateus, A. Grifoni, A. Tarke, J. Sidney, S. Ramirez, J. Dan, Z. Burger, Stephen A. Rawlings, Davey M. Smith, E. Phillips, S. Mallal, M. Lammers, Paul Rubiro, Lorenzo Quiambao, A. Sutherland, E. Yu, R. da Silva Antunes, J. Greenbaum, A. Frazier, A. Markmann, L. Premkumar, A. D. de Silva, Bjoern Peters, S. Crotty, A. Sette, D. Weiskopf   +25 more
semanticscholar   +1 more source

AI Aided Design of Epitope-Based Vaccine for the Induction of Cellular Immune Responses Against SARS-CoV-2

Frontiers in Genetics, 2021
The heavy burden imposed by the COVID-19 pandemic on our society triggered the race toward the development of therapies or preventive strategies. Among these, antibodies and vaccines are particularly attractive because of their high specificity, low ...
Giovanni Mazzocco, Iga Niemiec, Alexander Myronov, Alexander Myronov, Piotr Skoczylas, Jan Kaczmarczyk, Anna Sanecka-Duin, Katarzyna Gruba, Katarzyna Gruba, Paulina Król, Michał Drwal, Marian Szczepanik, Krzysztof Pyrc, Piotr Stȩpniak   +13 more
doaj   +1 more source