Results 11 to 20 of about 505,722 (385)

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

Science, 2021
A public anti-COVID antibody repertoire Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells.
William N. Voss, Yixuan J. Hou, N. Johnson, George Delidakis, Jin Eyun Kim, Kamyab Javanmardi, Andrew P. Horton, Foteini Bartzoka, Chelsea J. Paresi, Yuri Tanno, Chia-Wei Chou, Shawn A. Abbasi, Whitney Pickens, Katia George, D. Boutz, Dalton M. Towers, Jonathan R. McDaniel, Daniel Billick, Jule Goike, Lori Rowe, D. Batra, J. Pohl, Justin Lee, Shivaprakash Gangappa, S. Sambhara, M. Gadush, Nianshuang Wang, M. Person, B. Iverson, J. Gollihar, J. Dye, A. Herbert, Ilya J. Finkelstein, R. Baric, J. McLellan, G. Georgiou, Jason J. Lavinder, G. Ippolito   +37 more
semanticscholar   +1 more source

Predicting recognition between T cell receptors and epitopes with TCRGP

PLoS Comput. Biol., 2021
Adaptive immune system uses T cell receptors (TCRs) to recognize pathogens and to consequently initiate immune responses. TCRs can be sequenced from individuals and methods analyzing the specificity of the TCRs can help us better understand individuals ...
Emmi Jokinen, J. Huuhtanen, S. Mustjoki, Markus Heinonen, H. Lähdesmäki   +4 more
semanticscholar   +1 more source

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Science, 2020
Preexisting immune response to SARS-CoV-2 Robust T cell responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus occur in most individuals with coronavirus disease 2019 (COVID-19). Several studies have reported that some people
J. Mateus, A. Grifoni, A. Tarke, J. Sidney, S. Ramirez, J. Dan, Z. Burger, Stephen A. Rawlings, Davey M. Smith, E. Phillips, S. Mallal, M. Lammers, Paul Rubiro, Lorenzo Quiambao, A. Sutherland, E. Yu, R. da Silva Antunes, J. Greenbaum, A. Frazier, A. Markmann, L. Premkumar, A. D. de Silva, Bjoern Peters, S. Crotty, A. Sette, D. Weiskopf   +25 more
semanticscholar   +1 more source

Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

bioRxiv, 2020
Neutralizing antibody responses to coronaviruses focus on the trimeric spike, with most against the receptor-binding domain (RBD). Here we characterized polyclonal IgGs and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes.
C. Barnes, A. West, Kathryn E Huey-Tubman, Magnus A. G. Hoffmann, N. G. Sharaf, Pauline R. Hoffman, Nicholas S. Koranda, H. Gristick, C. Gaebler, F. Muecksch, J. C. Cetrulo Lorenzi, Shlomo Finkin, Thomas Hagglof, A. Hurley, Katrina G. Millard, Y. Weisblum, F. Schmidt, T. Hatziioannou, P. Bieniasz, M. Caskey, D. Robbiani, M. Nussenzweig, P. Bjorkman   +22 more
semanticscholar   +1 more source

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

Nature Communications, 2020
Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets.
C. Poh, G. Carissimo, Bei Wang, S. N. Amrun, C. Lee, R. Chee, Siew‐Wai Fong, N. Yeo, Wen‐Hsin Lee, Anthony Torres‐Ruesta, Y. Leo, M. Chen, S. Tan, L. Chai, S. Kalimuddin, Shirley Seah Gek Kheng, S. Thien, B. Young, D. Lye, B. Hanson, Cheng-I. Wang, L. Rénia, L. Ng   +22 more
semanticscholar   +1 more source

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

bioRxiv, 2020
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominance of different SARS-CoV-2 antigens, and precisely measure virus-specific CD4+ and CD8+ T cells, we studied epitope-specific T cell responses of ...
A. Tarke, J. Sidney, Conner K Kidd, J. Dan, S. Ramirez, E. Yu, J. Mateus, R. da Silva Antunes, Erin C Moore, Paul Rubiro, Nils Methot, E. Phillips, S. Mallal, A. Frazier, Stephen A. Rawlings, J. Greenbaum, Bjoern Peters, Davey M. Smith, S. Crotty, D. Weiskopf, A. Grifoni, A. Sette   +21 more
semanticscholar   +1 more source

Immunoinformatics‐aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019‐nCoV

Journal of Medical Virology, 2020
The 2019 novel coronavirus (2019‐nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia.
Vargab Baruah, S. Bose
semanticscholar   +1 more source

The epitope recognized by rituximab [PDF]

Blood, 2006
AbstractRituximab is a monoclonal antibody widely used in the treatment of malignant lymphoma and autoimmunity. Its epitope within the B-cell antigen CD20 is largely unknown. We used phage display libraries to select peptides binding to rituximab. Enriched peptides showed 2 sequence patterns: one motif (CALMIANSC) is related to (170)ANPS(173) within ...
Binder, Mascha, Otto, Florian, Mertelsmann, Roland, Veelken, Hendrik, Trepel, Martin   +4 more
openaire   +5 more sources

CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes [PDF]

, 2006
Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes,
Chan, A. T. C., Gudgeon, N. H., Hui, E. P., Jia, H., Lin, C. K., Lin, X., Rickinson, A. B., Taylor, G. S., Tsang, C. W.   +8 more
core   +1 more source

Immunoproteomics Reveals Pathogen’s Antigens Involved in Homo sapiens–Histoplasma capsulatum Interaction and Specific Linear B-Cell Epitopes in Histoplasmosis

Frontiers in Cellular and Infection Microbiology, 2020
Histoplasmosis is one of the most frequent systemic mycosis in HIV patients. In these patients, histoplasmosis has high rates of morbidity/mortality if diagnosis and treatment are delayed.
Marcos Abreu Almeida, Rodrigo Almeida-Paes, Allan Jefferson Guimarães, Richard Hemmi Valente, Célia Maria de Almeida Soares, Rosely Maria Zancopé-Oliveira   +5 more
doaj   +1 more source