Results 191 to 200 of about 505,722 (385)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Class 1 (unique) tumor antigens of human melanoma: identification of unique and common epitopes on a 90-kDa glycoprotein.

, 1988
Francisco X. Real, Koichi Furukawa, M. Jules Mattes, S A Gusik, Carlos Cordón-Cardo, Herbert F. Oettgen, Lloyd J. Old, Kenneth O. Lloyd   +7 more
openalex   +1 more source

Identification of proteases that process distinct epitopes on the same protein. [PDF]

, 1989
Hiroaki Takahashi, Kemp B. Cease, Jay A. Berzofsky   +2 more
openalex   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Identification and characterization of T helper epitopes in the nucleoprotein of influenza A virus. [PDF]

, 1989
Xiao‐Ming Gao, F Y Liew, J P Tite
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Conformational changes in an epitope localized to the NH2-terminal region of protein C

, 1989
Carolyn L. Orthner, Rapti D. Madurawe, William H. Velander, William N. Drohan, Frances D. Battey, Dudley K. Strickland   +5 more
openalex   +1 more source

Sequence of protective epitopes of streptococcal M proteins shared with cardiac sarcolemmal membranes. [PDF]

, 1987
Samantha Sargent, E H Beachey, Carlos Eduardo Pereira Corbett, James B. Dale   +3 more
openalex   +1 more source

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

Nature, 2015
S. Kreiter, M. Vormehr, Niels van de Roemer, M. Diken, M. Löwer, Jan Diekmann, Sebastian Boegel, Barbara Schroers, F. Vascotto, J. Castle, A. Tadmor, S. Schoenberger, C. Huber, Ö. Türeci, U. Şahin   +14 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source