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2003
An epitope is defined as the site on an antigen at which an antibody binds. In the case of proteins the epitopes can be classified as continuous (or sequential) and discontinuous according to whether or not the amino acids recognized are close together in the primary sequence or are well-separated but brought together by the folding of the protein. The
J E, Heckels, M, Christodoulides
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An epitope is defined as the site on an antigen at which an antibody binds. In the case of proteins the epitopes can be classified as continuous (or sequential) and discontinuous according to whether or not the amino acids recognized are close together in the primary sequence or are well-separated but brought together by the folding of the protein. The
J E, Heckels, M, Christodoulides
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Annual Review of Genetics, 1998
▪ Abstract  Epitope tagging is a recombinant DNA method by which a protein encoded by a cloned gene is made immunoreactive to a known antibody. This review discusses the major advantages and limitations of epitope tagging and describes a number of recent applications.
J W, Jarvik, C A, Telmer
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▪ Abstract  Epitope tagging is a recombinant DNA method by which a protein encoded by a cloned gene is made immunoreactive to a known antibody. This review discusses the major advantages and limitations of epitope tagging and describes a number of recent applications.
J W, Jarvik, C A, Telmer
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ACS Infectious Diseases, 2022
The ongoing coronavirus disease 2019 pandemic has raised concerns about the risk of re-infection. Non-neutralizing epitopes are one of the major reasons for antibody-dependent enhancement. Past studies on the ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have revealed an infectivity-enhancing site on the ancestral SARS-CoV-2 ...
Hua-Rui Gong +5 more
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The ongoing coronavirus disease 2019 pandemic has raised concerns about the risk of re-infection. Non-neutralizing epitopes are one of the major reasons for antibody-dependent enhancement. Past studies on the ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have revealed an infectivity-enhancing site on the ancestral SARS-CoV-2 ...
Hua-Rui Gong +5 more
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Molecular Biotechnology, 1994
Monoclonal antibodies (MAbs) are specific immunological tools because they bind to a precise determinant (the epitope) on the surface of a protein. The procedure of identifying the binding site of a MAb is often termed "epitope mapping."
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Monoclonal antibodies (MAbs) are specific immunological tools because they bind to a precise determinant (the epitope) on the surface of a protein. The procedure of identifying the binding site of a MAb is often termed "epitope mapping."
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1998
Epitope mapping can be used to identify areas of a protein that an antibody recognizes and binds to. Monoclonal antibodies are easier to characterize, but epitope maps can also be produced for polyclonal antisera.
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Epitope mapping can be used to identify areas of a protein that an antibody recognizes and binds to. Monoclonal antibodies are easier to characterize, but epitope maps can also be produced for polyclonal antisera.
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Autoimmune epitopes: autoepitopes
Autoimmunity Reviews, 2004The identity of reactants for autoantibodies has been successively refined from whole cellular organelles (immunofluorescence), identified molecules (immunoblot; gene expression libraries), epitope regions (truncated cDNAs; peptide scanning) to contact residues, as described here.
Ian R, Mackay, Merrill J, Rowley
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Seminars in Oncology, 2006
Variable expression of the HER2 receptor has been implicated in the pathogenesis of a number of malignancies. Many therapeutic modalities have been devised that target the receptor and downstream molecular pathways. The humanized monoclonal antibodies trastuzumab and pertuzumab bind epitopes on the extracellular domain, resulting in cell growth ...
Sumanta Kumar, Pal, Mark, Pegram
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Variable expression of the HER2 receptor has been implicated in the pathogenesis of a number of malignancies. Many therapeutic modalities have been devised that target the receptor and downstream molecular pathways. The humanized monoclonal antibodies trastuzumab and pertuzumab bind epitopes on the extracellular domain, resulting in cell growth ...
Sumanta Kumar, Pal, Mark, Pegram
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Immunology Letters, 2005
We have developed a widely applicable method to construct epitope-peptide gene for epitope-vaccine strategy recently. In this study, we wanted to know whether the predefined spacers between epitopes on a recombinant epitope-peptide impacted the production of epitope-specific antibodies.
Zuqiang, Liu +2 more
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We have developed a widely applicable method to construct epitope-peptide gene for epitope-vaccine strategy recently. In this study, we wanted to know whether the predefined spacers between epitopes on a recombinant epitope-peptide impacted the production of epitope-specific antibodies.
Zuqiang, Liu +2 more
openaire +2 more sources