Results 261 to 270 of about 489,867 (407)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Subtractive proteomics and reverse-vaccinology approaches for novel drug targets and designing a chimeric vaccine against <i>Ruminococcus gnavus</i> strain RJX1120. [PDF]

Front Immunol
Dingding H, Muhammad S, Manzoor I, Ghaffar SA, Alodaini HA, Moubayed NM, Hatamleh AA, Songxiao X.   +7 more
europepmc   +1 more source

Complete nucleotide sequence of the gene encoding VP4 of a human rotavirus (strain K8) which has unique VP4 neutralization epitopes [PDF]

, 1989
K. Taniguchi, K Nishikawa, Tomoko Urasawa, Shozo Urasawa, K Midthun, Albert Z. Kapikian, M Gorziglia   +6 more
openalex   +1 more source

TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes

Proceedings of the National Academy of Sciences of the United States of America, 2015
D. Chowell, S. Krishna, P. Becker, Clément Cocita, Jack Shu, X. Tan, P. Greenberg, L. Klavinskis, J. Blattman, K. Anderson   +9 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis. [PDF]

Parasit Vectors
Zhang J, Lv T, Tan S, Yu L, Chi Y, Chen J, Fan X, Lu X.   +7 more
europepmc   +1 more source

Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes. [PDF]

, 1986
Margaret Haugh, A. Probst, J. Ulrich, J. Kahn, Brian H. Anderton   +4 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

New Advances in the Development and Design of <i>Mycobacterium tuberculosis</i> Vaccines: Construction and Validation of Multi-Epitope Vaccines for Tuberculosis Prevention. [PDF]

Biology (Basel)
Barazani O, Erdos T, Chowdhury R, Kaur G, Venketaraman V.   +4 more
europepmc   +1 more source

Conservation of epitopes in the oligosaccharide portion of the lipooligosaccharide of Haemophilus influenzae type b [PDF]

, 1987
P A Gulig, C C Patrick, L Hermanstorfer, George H. McCracken, E J Hansen   +4 more
openalex   +1 more source