Results 21 to 30 of about 491,390 (408)

Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

bioRxiv, 2020
Neutralizing antibody responses to coronaviruses focus on the trimeric spike, with most against the receptor-binding domain (RBD). Here we characterized polyclonal IgGs and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes.
C. Barnes, A. West, Kathryn E Huey-Tubman, Magnus A. G. Hoffmann, N. G. Sharaf, Pauline R. Hoffman, Nicholas S. Koranda, H. Gristick, C. Gaebler, F. Muecksch, J. C. Cetrulo Lorenzi, Shlomo Finkin, Thomas Hagglof, A. Hurley, Katrina G. Millard, Y. Weisblum, F. Schmidt, T. Hatziioannou, P. Bieniasz, M. Caskey, D. Robbiani, M. Nussenzweig, P. Bjorkman   +22 more
semanticscholar   +1 more source

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

bioRxiv, 2020
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominance of different SARS-CoV-2 antigens, and precisely measure virus-specific CD4+ and CD8+ T cells, we studied epitope-specific T cell responses of ...
A. Tarke, J. Sidney, Conner K Kidd, J. Dan, S. Ramirez, E. Yu, J. Mateus, R. da Silva Antunes, Erin C Moore, Paul Rubiro, Nils Methot, E. Phillips, S. Mallal, A. Frazier, Stephen A. Rawlings, J. Greenbaum, Bjoern Peters, Davey M. Smith, S. Crotty, D. Weiskopf, A. Grifoni, A. Sette   +21 more
semanticscholar   +1 more source

Characterization of the B-Cell Epitopes of Echinococcus granulosus Histones H4 and H2A Recognized by Sera From Patients With Liver Cysts

Frontiers in Cellular and Infection Microbiology, 2022
Cystic echinococcosis (CE) is a zoonotic disease worldwide distributed, caused by the cestode Echinococcus granulosus sensu lato (E. granulosus), with an incidence rate of 50/100,000 person/year and a high prevalence in humans of 5-10%.
Andrea Maglioco, Andrea Maglioco, Facundo A. Agüero, Facundo A. Agüero, María Pía Valacco, Alejandra Juárez Valdez, Margot Paulino, Alicia G. Fuchs, Alicia G. Fuchs   +8 more
doaj   +1 more source

In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate [PDF]

Vaccine Research, 2020
Introduction: The development of a vaccine against Staphylococcus aureus has proven to be much more difficult than expected. In this study, we considered and analyzed a mutant Toxic Shock Syndrome Toxin-1 (TSST-1) as a potential vaccine candidate ...
Mohsen Nazari, Farzad Badmasti
doaj   +1 more source

BeeTLe: A Framework for Linear B-Cell Epitope Prediction and Classification [PDF]

, 2023
The process of identifying and characterizing B-cell epitopes, which are the portions of antigens recognized by antibodies, is important for our understanding of the immune system, and for many applications including vaccine development, therapeutics, and diagnostics.
arxiv   +1 more source

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

Nature Communications, 2020
Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets.
C. Poh, G. Carissimo, Bei Wang, S. N. Amrun, C. Lee, R. Chee, Siew‐Wai Fong, N. Yeo, Wen‐Hsin Lee, Anthony Torres‐Ruesta, Y. Leo, M. Chen, S. Tan, L. Chai, S. Kalimuddin, Shirley Seah Gek Kheng, S. Thien, B. Young, D. Lye, B. Hanson, Cheng-I. Wang, L. Rénia, L. Ng   +22 more
semanticscholar   +1 more source

Immunoinformatics‐aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019‐nCoV

Journal of Medical Virology, 2020
The 2019 novel coronavirus (2019‐nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia.
Vargab Baruah, S. Bose
semanticscholar   +1 more source

Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins

Frontiers in Immunology, 2018
BackgroundIt has been shown earlier that there is a rise in the levels of autoantibodies and T cell response to cytoskeletal proteins in leprosy. Our group recently demonstrated a rise in both T and B cell responses to keratin and myelin basic protein in
Itu Singh, Asha Ram Yadav, Keshar Kunja Mohanty, Kiran Katoch, Prashant Sharma, Vinay Kumar Pathak, Deepa Bisht, Umesh D. Gupta, Utpal Sengupta   +8 more
doaj   +1 more source

Interaction Between Virus-Like Particles (VLPs) and Pattern Recognition Receptors (PRRs) From Dendritic Cells (DCs): Toward Better Engineering of VLPs

Frontiers in Immunology, 2020
Virus-like particles (VLPs) have been shown to be strong activators of dendritic cells (DCs). DCs are the most potent antigen presenting cells (APCs) and their activation prompts the priming of immunity mediators based on B and T cells.
Jesús Zepeda-Cervantes, Josué Orlando Ramírez-Jarquín, Luis Vaca, Luis Vaca   +3 more
doaj   +1 more source

Immunoproteomics Reveals Pathogen’s Antigens Involved in Homo sapiens–Histoplasma capsulatum Interaction and Specific Linear B-Cell Epitopes in Histoplasmosis

Frontiers in Cellular and Infection Microbiology, 2020
Histoplasmosis is one of the most frequent systemic mycosis in HIV patients. In these patients, histoplasmosis has high rates of morbidity/mortality if diagnosis and treatment are delayed.
Marcos Abreu Almeida, Rodrigo Almeida-Paes, Allan Jefferson Guimarães, Richard Hemmi Valente, Célia Maria de Almeida Soares, Rosely Maria Zancopé-Oliveira   +5 more
doaj   +1 more source