Results 21 to 30 of about 228,208 (297)

Finding Epitopes with Computers

Chemistry & Biology, 2013
The goal of structural vaccinology is to enable the design and engineering of improved antigens. In a recent issue of Chemistry & Biology, Gourlay and colleagues provided evidence that structure-based computational methods allow prediction of B cell epitopes, a crucial step for antigen selection and optimization in vaccine development.
Rino Rappuoli, Enrico Malito
openaire   +3 more sources

Prediction of T-Cell Epitope

Journal of Pharmacological Sciences, 2007
The prevailing methods to predict T-cell epitopes are reviewed. Motif matching, matrix, support vector machine (SVM), and empirical scoring function methods are mainly reviewed; and the thermodynamic integration (TI) method using all-atom molecular dynamics (MD) simulation is mentioned briefly.
Takuya Takahashi, Hiromichi Tsurui
openaire   +5 more sources

Schistosoma mansoni SmKI-1 or Its C-Terminal Fragment Induces Partial Protection Against S. mansoni Infection in Mice

Frontiers in Immunology, 2018
Current schistosomiasis control strategies are mainly based on chemotherapy, but the development of a vaccine against this parasitic disease would contribute to a long-lasting decrease in disease spectrum and transmission.
Suellen B. Morais, Suellen B. Morais, Barbara C. Figueiredo, Barbara C. Figueiredo, Barbara C. Figueiredo, Natan R. G. Assis, Natan R. G. Assis, Jane Homan, Fábio S. Mambelli, Rodrigo M. Bicalho, Cláudia Souza, Vicente P. Martins, Carina S. Pinheiro, Sergio C. Oliveira, Sergio C. Oliveira   +14 more
doaj   +1 more source

Recombinantly Expressed Chimeric Fibers Demonstrate Discrete Type-Specific Neutralizing Epitopes in the Fowl Aviadenovirus E (FAdV-E) Fiber, Promoting the Optimization of FAdV Fiber Subunit Vaccines towards Cross-Protection in vivo

Microbiology Spectrum, 2022
Vaccines against inclusion body hepatitis in chickens are complicated by the involvement of antigenically diverse fowl adenovirus types. Though immunization with fiber protein confers robust protection, type specificity of fiber antibodies is an obstacle
Anna Schachner, Carlotta De Luca, Sarah Heidl, Michael Hess   +3 more
doaj   +1 more source

Comprehensive Overview of Broadly Neutralizing Antibodies against SARS-CoV-2 Variants

Viruses
Currently, SARS-CoV-2 has evolved into various variants, including the numerous highly mutated Omicron sub-lineages, significantly increasing immune evasion ability. The development raises concerns about the possibly diminished effectiveness of available
Lingyan Cui, Tingting Li, Wenhui Xue, Sibo Zhang, Hong Wang, Hongjing Liu, Ying Gu, Ningshao Xia, Shaowei Li   +8 more
doaj   +1 more source

Defining the epichromatin epitope [PDF]

Nucleus, 2017
Epichromatin is identified by immunostaining fixed and permeabilized cells with particular bivalent anti-nucleosome antibodies (mAbs PL2-6 and 1H6). During interphase, epichromatin resides adjacent to the inner nuclear membrane; during mitosis, at the outer surface of mitotic chromosomes.
Travis J. Gould, Katalin Tóth, Norbert Mücke, Jörg Langowski, Alexandra S. Hakusui, Ada L. Olins, Donald E. Olins   +6 more
openaire   +3 more sources

A Basic Molecular Analysis of the Diabetic Antigen GAD by Homology Modelling. Principles of the Method and Understanding of Antigenicity and Binding Sites

Pteridines, 2007
Functional specificity of a protein is linked to its structure. A growing section of bioinformatics deals with the prediction and visualization of protein 3D structures.
Wiltgen Marco, Tilz Gernot P.
doaj   +1 more source

Identification of B-Cell Epitopes with Potential to Serologicaly Discrimnate Dengue from Zika Infections

Viruses, 2019
Dengue is currently one of the most important arbovirus infections worldwide. Early diagnosis is important for disease outcome, particularly for those afflicted with the severe forms of infection.
Alice F. Versiani, Raissa Prado Rocha, Tiago A. O. Mendes, Glauco C. Pereira, Jordana Graziella A. Coelho dos Reis, Daniella C. Bartholomeu, Flávio G. da Fonseca   +6 more
doaj   +1 more source

Computational Prediction of B-cell Epitopes of Mycobacterium tuberculosis-Implications in Vaccine Design

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2021
Introduction: Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis. Bacillus Calmette-Guérin is the only vaccine available for TB.
Esakkimuthu THANGAMARIAPPAN, Manikandan MOHAN, Krishnan SUNDAR   +2 more
doaj   +1 more source

A Novel Algorithm for Macromolecular Epitope Matching

Algorithms, 2009
Many macromolecules, namely proteins, show functional substructures or epitopes defined by characteristic spatial arrangements of groups of specific atoms or residues.
Stanislav Jakuschev, Daniel Hoffmann
doaj   +1 more source